Vol 51, No 1 (2013)
Original paper
Published online: 2013-04-24

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Kainic acid induces expression of caveolin-1 in activated microglia in rat brain

Shigeko Takeuchi, Wakoto Matsuda, Ikuo Tooyama, Osamu Yasuhara
DOI: 10.5603/FHC.2013.004
Folia Histochem Cytobiol 2013;51(1):25-30.


Caveolin-1, a major constituent of caveolae, has been implicated in endocytosis, signal transduction and cholesterol transport in a wide variety of cells. In the present study, the expression of caveolin-1 was examined by immunohistochemistry in rat brain with or without systemic injection of kainic acid (KA). Caveolin-1 immunoreactivity was observed in capillary walls in brains of control rats. From one to seven days after KA injection, caveolin-1 immunoreactivity appeared in activated microglia in the cerebral cortex, hippocampus and other brain regions. The strongest immunoreactivity of microglia was seen after 3 days after KA administration. The expression of caveolin-1 was confirmed by RT-PCR and Western blot analysis, respectively. The induction of caveolin-1 expression in microglia activated in response to kainic acid administration suggests its possible role in a modulation of inflammation. (Folia Histochemica et Cytobiologica 2013, Vol. 51, No. 1, 25–30)

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