open access

Vol 50, No 4 (2012)
Original paper
Submitted: 2012-12-23
Accepted: 2012-12-23
Published online: 2012-12-23
Get Citation

Production of cytokines by mononuclear cells of hypertrophic adenoids in children with otitis media with effusion

Beata Zelazowska-Rutkowska, Elzbieta Ilendo, Bozena Skotnicka, Jolanta Wysocka, Edwina Kasprzycka
DOI: 10.5603/FHC.2012.0082
·
Folia Histochem Cytobiol 2012;50(4):586-589.

open access

Vol 50, No 4 (2012)
ORIGINAL PAPERS
Submitted: 2012-12-23
Accepted: 2012-12-23
Published online: 2012-12-23

Abstract

Hypertrophic adenoids with otitis media with effusion is a common infectious disease and present
a serious otological problem in children. Cytokines, potent inflammatory mediators, play important role in the
initiation of immunological response in otitis media. Adenoids excised due to hypertrophy with or without chronic
otitis media with effusion were used to isolate mononuclear cells. Secretion of cytokines by non-stimulated and
PHA-stimulated cells was determined by specific ELISAs. We found a significant increase in the production of
IL-5 and TNF-a secreted by adenoidal cells of children with otitis media with effusion compared to group with
hypertrophic adenoids. No differences were found in the secretion of IL-8, IL-6, and IL-10 between these two
groups of patients. Our results suggest a difference between the immunological responses in the course of hypertrophic
adenoids with otitis media as compared to hypertrophic adenoids.

Abstract

Hypertrophic adenoids with otitis media with effusion is a common infectious disease and present
a serious otological problem in children. Cytokines, potent inflammatory mediators, play important role in the
initiation of immunological response in otitis media. Adenoids excised due to hypertrophy with or without chronic
otitis media with effusion were used to isolate mononuclear cells. Secretion of cytokines by non-stimulated and
PHA-stimulated cells was determined by specific ELISAs. We found a significant increase in the production of
IL-5 and TNF-a secreted by adenoidal cells of children with otitis media with effusion compared to group with
hypertrophic adenoids. No differences were found in the secretion of IL-8, IL-6, and IL-10 between these two
groups of patients. Our results suggest a difference between the immunological responses in the course of hypertrophic
adenoids with otitis media as compared to hypertrophic adenoids.
Get Citation
About this article
Title

Production of cytokines by mononuclear cells of hypertrophic adenoids in children with otitis media with effusion

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 4 (2012)

Article type

Original paper

Pages

586-589

Published online

2012-12-23

DOI

10.5603/FHC.2012.0082

Bibliographic record

Folia Histochem Cytobiol 2012;50(4):586-589.

Authors

Beata Zelazowska-Rutkowska
Elzbieta Ilendo
Bozena Skotnicka
Jolanta Wysocka
Edwina Kasprzycka

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