open access

Vol 50, No 4 (2012)
Original paper
Submitted: 2012-12-23
Accepted: 2012-12-23
Published online: 2012-12-23
Get Citation

E-cadherin expression is more associated with histopathological type of thyroid cancer than with the metastatic potential of tumors

Dorota Slowinska-Klencka, Stanislaw Sporny, Olga Stasikowska-Kanicka, Bozena Popowicz, Mariusz Klencki
DOI: 10.5603/FHC.2012.0073
·
Folia Histochem Cytobiol 2012;50(4):519-526.

open access

Vol 50, No 4 (2012)
ORIGINAL PAPERS
Submitted: 2012-12-23
Accepted: 2012-12-23
Published online: 2012-12-23

Abstract

The aim of this study was to evaluate the relationship between abnormal expression of E-cadherin
(E-CAD) and the extracapsular extension of tumors, lymph node involvement and the presence of metastasis in
various types of thyroid cancers. Histopathological specimens of 35 benign thyroid lesions and 122 malignant
tumors (papillary, follicular, poorly differentiated and undifferentiated cancers) were analyzed. E-CAD immunostaining
intensity, its subcellular localization, homogeneity within lesion, and the relation of staining intensity
between tumor and surrounding thyroid parenchyma were evaluated. The obtained results show that the variants
of differentiated cancers with a poorer prognosis (i.e. tall cell and follicular variants of papillary cancer and
widely invasive follicular cancers) present reduced intensity of E-CAD expression, its abnormal localization or
heterogeneity of staining more frequently than classical papillary cancers and minimally invasive follicular cancers.
However, the assessment of E-CAD expression does not allow the prediction of extrathyroidal growth of
thyroid cancers.

Abstract

The aim of this study was to evaluate the relationship between abnormal expression of E-cadherin
(E-CAD) and the extracapsular extension of tumors, lymph node involvement and the presence of metastasis in
various types of thyroid cancers. Histopathological specimens of 35 benign thyroid lesions and 122 malignant
tumors (papillary, follicular, poorly differentiated and undifferentiated cancers) were analyzed. E-CAD immunostaining
intensity, its subcellular localization, homogeneity within lesion, and the relation of staining intensity
between tumor and surrounding thyroid parenchyma were evaluated. The obtained results show that the variants
of differentiated cancers with a poorer prognosis (i.e. tall cell and follicular variants of papillary cancer and
widely invasive follicular cancers) present reduced intensity of E-CAD expression, its abnormal localization or
heterogeneity of staining more frequently than classical papillary cancers and minimally invasive follicular cancers.
However, the assessment of E-CAD expression does not allow the prediction of extrathyroidal growth of
thyroid cancers.
Get Citation
About this article
Title

E-cadherin expression is more associated with histopathological type of thyroid cancer than with the metastatic potential of tumors

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 4 (2012)

Article type

Original paper

Pages

519-526

Published online

2012-12-23

DOI

10.5603/FHC.2012.0073

Bibliographic record

Folia Histochem Cytobiol 2012;50(4):519-526.

Authors

Dorota Slowinska-Klencka
Stanislaw Sporny
Olga Stasikowska-Kanicka
Bozena Popowicz
Mariusz Klencki

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