open access

Vol 50, No 1 (2012)
Review paper
Submitted: 2012-04-24
Accepted: 2012-04-24
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Role of cathepsin A and cathepsin C in the regulation of glycosidase activity

Alina Minarowska, Łukasz Minarowski, Alicja Karwowska, Anna Justyna Milewska, Marek Gacko
DOI: 10.5603/FHC.2012.0003
·
Folia Histochem Cytobiol 2012;50(1):20-24.

open access

Vol 50, No 1 (2012)
REVIEW
Submitted: 2012-04-24
Accepted: 2012-04-24

Abstract

Increased tissue activity of cathepsin A and cathepsin C can be observed in many pathological conditions. It is associated with an enhanced degradation of glycosaminoglycans, proteoglycans, and glycoproteins, and results in their decreased tissue content. Cathepsin C releases the glycosidases from complexes formed with cathepsin A, and reinstates their activity. In this review a current state of knowledge is presented concerning the regulation of selected glycosidases activity by cathepsin A (EC 3.4.16.1) and C (EC 3.4.14.1).

Abstract

Increased tissue activity of cathepsin A and cathepsin C can be observed in many pathological conditions. It is associated with an enhanced degradation of glycosaminoglycans, proteoglycans, and glycoproteins, and results in their decreased tissue content. Cathepsin C releases the glycosidases from complexes formed with cathepsin A, and reinstates their activity. In this review a current state of knowledge is presented concerning the regulation of selected glycosidases activity by cathepsin A (EC 3.4.16.1) and C (EC 3.4.14.1).
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Keywords

cathepsin A; lysosomal carboxypeptidase A; cathepsin C; dipeptydyl peptidase I; glycosidase activity

About this article
Title

Role of cathepsin A and cathepsin C in the regulation of glycosidase activity

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 1 (2012)

Article type

Review paper

Pages

20-24

DOI

10.5603/FHC.2012.0003

Bibliographic record

Folia Histochem Cytobiol 2012;50(1):20-24.

Keywords

cathepsin A
lysosomal carboxypeptidase A
cathepsin C
dipeptydyl peptidase I
glycosidase activity

Authors

Alina Minarowska
Łukasz Minarowski
Alicja Karwowska
Anna Justyna Milewska
Marek Gacko

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