open access

Vol 50, No 4 (2012)
Review paper
Submitted: 2012-02-12
Accepted: 2012-11-04
Published online: 2012-12-23
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Melanoma and other malignant skin cancers in psoriatic patients treated with phototherapy. Role of the p16 protein in psoriasis

Anna Szponar-Bojda, Aldona Pietrzak, Agnieszka Agnieszka Sobczyńska-Tomaszewska, Adam Borzęcki, Andrzej Kurylcio, Wojciech Polkowski, Anna Poluha, Grażyna Chodorowska
DOI: 10.5603/FHC.2012.0069
·
Folia Histochem Cytobiol 2012;50(4):491-496.

open access

Vol 50, No 4 (2012)
REVIEW
Submitted: 2012-02-12
Accepted: 2012-11-04
Published online: 2012-12-23

Abstract

Recently, the potential risk of malignant skin cancer development in psoriatic patients has been highlighted. It seems that some pathogenetic factors in psoriasis could predispose to a malignant transformation. So far, the relationship between the therapeutic schemes in psoriasis and possible neoplastic transformation has not been clearly explained. The phototherapy is considered a very effective therapeutic method in psoriasis, however, the pathogenesis of some malignancies is associated with the exposure to UV radiation.

One of the defence mechanisms that protect the cells from damaging and mutagenic factors, such as UV radiation, seems to be the p16 protein. Moreover, in recent years, the altered expression of the p16 protein in the diseases not related to malignant transformation, including psoriasis, has been observed. The new hypothesis suggesting a participation of the p16 protein in psoriatic plaque formation has appeared.

Abstract

Recently, the potential risk of malignant skin cancer development in psoriatic patients has been highlighted. It seems that some pathogenetic factors in psoriasis could predispose to a malignant transformation. So far, the relationship between the therapeutic schemes in psoriasis and possible neoplastic transformation has not been clearly explained. The phototherapy is considered a very effective therapeutic method in psoriasis, however, the pathogenesis of some malignancies is associated with the exposure to UV radiation.

One of the defence mechanisms that protect the cells from damaging and mutagenic factors, such as UV radiation, seems to be the p16 protein. Moreover, in recent years, the altered expression of the p16 protein in the diseases not related to malignant transformation, including psoriasis, has been observed. The new hypothesis suggesting a participation of the p16 protein in psoriatic plaque formation has appeared.

Get Citation
About this article
Title

Melanoma and other malignant skin cancers in psoriatic patients treated with phototherapy. Role of the p16 protein in psoriasis

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 50, No 4 (2012)

Article type

Review paper

Pages

491-496

Published online

2012-12-23

DOI

10.5603/FHC.2012.0069

Bibliographic record

Folia Histochem Cytobiol 2012;50(4):491-496.

Authors

Anna Szponar-Bojda
Aldona Pietrzak
Agnieszka Agnieszka Sobczyńska-Tomaszewska
Adam Borzęcki
Andrzej Kurylcio
Wojciech Polkowski
Anna Poluha
Grażyna Chodorowska

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