open access

Vol 49, No 4 (2011)
Original paper
Submitted: 2012-01-16
Published online: 2012-01-16
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Control of active B and L cathepsins in tissues of colorectal cancer using cystatins isolated from chicken egg proteins: in vitro studies

Andrzej Hap, Wojciech Kielan, Zygmunt Grzebieniak, Maciej Siewinski, Jerzy Rudnicki, Robert Tarnawa, Julia Rudno-Rudzinska, Anil Kumar Agrawal
DOI: 10.5603/FHC.2011.0075
·
Folia Histochem Cytobiol 2011;49(4):670-676.

open access

Vol 49, No 4 (2011)
ORIGINAL PAPERS
Submitted: 2012-01-16
Published online: 2012-01-16

Abstract

The activity of cysteine peptidases (cathepsins B and L) was estimated in homogenates of tissues sampled during surgery from 60 patients operated due to colorectal tumors. The results were compared to those obtained using tissues in which histopathology disclosed no tumorous cells, obtained from 20 patients of the same group, treated as a control. Activity of the enzymes was inhibited using cysteine peptidase inhibitors isolated from chicken egg proteins. Application of the inhibitors was found to inhibit activity of the enzymes which play a key role in tumor development. It is suggested that in future the inhibitors may provide a component of new generation drugs in the so-called inhibitor therapy. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 670–676)

Abstract

The activity of cysteine peptidases (cathepsins B and L) was estimated in homogenates of tissues sampled during surgery from 60 patients operated due to colorectal tumors. The results were compared to those obtained using tissues in which histopathology disclosed no tumorous cells, obtained from 20 patients of the same group, treated as a control. Activity of the enzymes was inhibited using cysteine peptidase inhibitors isolated from chicken egg proteins. Application of the inhibitors was found to inhibit activity of the enzymes which play a key role in tumor development. It is suggested that in future the inhibitors may provide a component of new generation drugs in the so-called inhibitor therapy. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 670–676)
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Keywords

large intestine; cystatins; cathepsins

About this article
Title

Control of active B and L cathepsins in tissues of colorectal cancer using cystatins isolated from chicken egg proteins: in vitro studies

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 49, No 4 (2011)

Article type

Original paper

Pages

670-676

Published online

2012-01-16

DOI

10.5603/FHC.2011.0075

Bibliographic record

Folia Histochem Cytobiol 2011;49(4):670-676.

Keywords

large intestine
cystatins
cathepsins

Authors

Andrzej Hap
Wojciech Kielan
Zygmunt Grzebieniak
Maciej Siewinski
Jerzy Rudnicki
Robert Tarnawa
Julia Rudno-Rudzinska
Anil Kumar Agrawal

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