open access

Vol 49, No 4 (2011)
Review paper
Submitted: 2012-01-16
Published online: 2012-01-16
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Cryoglobulinemic glomerulonephritis — lessons from animal models

Jolanta Kowalewska
DOI: 10.5603/FHC.2011.0077
·
Folia Histochem Cytobiol 2011;49(4):537-546.

open access

Vol 49, No 4 (2011)
REVIEW
Submitted: 2012-01-16
Published online: 2012-01-16

Abstract

In humans cryoglobulinemic glomerulonephritis (CGGN) may develop in the course of systemic cryoglobulinemia (CG) and is often associated with hepatitis C virus infection. It is believed that the glomerular injury in CG results from the deposition of immune complexes, but exact sequence of events in this process is unknown. Experimental models of CGGN provide an important tool to study pathogenesis of this type injury. This review describes two mouse models of CGGN and their use in understanding the role of various molecules involved in regulation of inflammatory and fibrosis pathways, such as complement components, Fc receptors, growth factors, and others; as well as illustrates their role in testing novel approaches of treatment in this type of renal injury. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 537–546)

Abstract

In humans cryoglobulinemic glomerulonephritis (CGGN) may develop in the course of systemic cryoglobulinemia (CG) and is often associated with hepatitis C virus infection. It is believed that the glomerular injury in CG results from the deposition of immune complexes, but exact sequence of events in this process is unknown. Experimental models of CGGN provide an important tool to study pathogenesis of this type injury. This review describes two mouse models of CGGN and their use in understanding the role of various molecules involved in regulation of inflammatory and fibrosis pathways, such as complement components, Fc receptors, growth factors, and others; as well as illustrates their role in testing novel approaches of treatment in this type of renal injury. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 4, pp. 537–546)
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Keywords

cryoglobulinemia; glomerulonephritis; animal models

About this article
Title

Cryoglobulinemic glomerulonephritis — lessons from animal models

Journal

Folia Histochemica et Cytobiologica

Issue

Vol 49, No 4 (2011)

Article type

Review paper

Pages

537-546

Published online

2012-01-16

DOI

10.5603/FHC.2011.0077

Bibliographic record

Folia Histochem Cytobiol 2011;49(4):537-546.

Keywords

cryoglobulinemia
glomerulonephritis
animal models

Authors

Jolanta Kowalewska

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