Dzienne nasłonecznie jako determinant stężenia 25-hydroksywitaminy D u pacjentów z cukrzycą i chorobami serca po hospitalizacji z powodu zawału serca z powodu ostrego zespołu wieńcowego — badanie przekrojowe
Streszczenie
Wstęp. Niedobór witaminy D jest problemem ogólnoświatowym o różnych konsekwencjach zdrowotnych. Witamina D może obniżać ryzyko niewydolności serca, jednak dowody świadczące o skuteczności suplementacji witaminą D na utrzymanie zdrowia układu sercowo-naczyniowego są sprzeczne z powodu braku odpowiedniej liczby i jakości badań klinicznych. Przyczyny braku jednoznacznych efektów potwierdzających pozytywny wpływ suplementacji witaminy D mogą być co najmniej trzy: 1) suplementacja zbyt małą ilością witaminy D lub 2) brak włączenia do badania tylko populacji z ciężkim niedoborem witaminy D, lub 3) czas trwania suplementacji. Celem pracy była charakterystyka grupy pacjentów kardiologicznych, u których stwierdzono w poprzednich badaniach najniższe stężenia 25-hydroksywitaminy D [25(OH)D].
Materiał i metody. Analizie poddano wyniki 92 chorych kardiologicznych z cukrzycą w wieku 41–89 lat, którzy przeżyli zawał serca z istotnymi zmianami w tętnicach wieńcowych, hospitalizowanych z powodu ostrego zespołu wieńcowego, mieszkających w Warszawie.
Wyniki. Mediana stężenia 25(OH)D w badanej populacji wyniosła 11 ng/ml (zakres: 4–28 ng/ml). Jedynym istotnym determinantem stężenia 25(OH)D był okres badania; stężenie było wyższe latem niż zimą.
Wnioski. Leczenie witaminą D u polskich pacjentów kardiologicznych w celu osiągnięcia optymalnego stężenia, tj. 30 ng/ml (75 nmol/l), wydaje się konieczne i powinno być jak najszybciej wdrożone.
Słowa kluczowe: witamina Dniedobór witaminy Dchoroby układu krążenia
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