Vol 14, No 1 (2019)
Heart failure
Published online: 2019-04-10
Sacubitril/valsartan in clinical practice
DOI: 10.5603/FC.2019.0002
Folia Cardiologica 2019;14(1):95-105.
Abstract
In a landmark multi-center, phase III, randomized controlled trial — PARADIGM-HF, that investigated long-term effects and safety of novel class of agents — angiotensin receptor antagonist/neprilisin inhibitor (ARNI) — LCZ696 (sacubitril/ /valsartan) in comparison with enalapril, clear clinical benefit was shown in patients with heart failure with reduced ejection fraction (HFrEF) who were subjected to sacubitril/valsartan. Sacubitril/valsartan (EntrestoTM) has been avai- lable in Poland for the last two years. The present document is a practical guide for all those physicians who would like to initiate this new therapy for the first time and also for those have gathered so far some experience with EntrestoTM.
Keywords: heart failure with reduced ejection fractionsacubitril/valsartan
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