Tom 13, Nr 5 (2018)
Artykuł przeglądowy
Opublikowany online: 2018-09-13
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Związek układu serotoninergicznego i układu sercowo-naczyniowego
Folia Cardiologica 2018;13(5):420-427.
Streszczenie
Serotonina (5-HT) odgrywa istotną rolę w regulacji układu sercowo-naczyniowego. Leki wpływające na układ serotoninergiczny powszechnie stosuje się w terapii depresji, migreny, choroby Parkinsona czy otyłości. W zależności od rodzaju aktywowanego receptora 5-HT i jego lokalizacji przyjmowanie tych związków może prowadzić do ostrych i przewlekłych skutków. Przykładem takiego oddziaływania jest ostra odpowiedź kardiologiczna na serotoninę, zwana odruchem Bezolda-Jarisha, która prowadzi do bradykardii i hipotonii. Przewlekła ekspozycja na nadmiar serotoniny może natomiast łączyć się z włóknieniem i zwyrodnieniem zastawek serca. W artykule omówiono wpływ aktywacji poszczególnych
receptorów 5-HT na układ sercowo-naczyniowy, działania niepożądane stosowanych leków, a także wskazano nowe
możliwości terapii.
Słowa kluczowe: serotoninaremodeling sercowo-naczyniowyzwyrodnienie zastawekwłóknienieodruch Bezolda-Jarischa
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