open access

Vol 11, No 6 (2016)
Cardiac Surgery
Published online: 2017-01-17
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Right atrial myxoma in a patient with systemic sclerosis: a paraneoplastic syndrome or the coexistence of two diseases connected to increase in interleukin 6

Małgorzata Peregud-Pogorzelska, Beata Trzcińska-Budkiewicz, Jarosław Kaźmierczak, Maciej Wielusiński, Marek Zieliński, Marek Brzosko
DOI: 10.5603/FC.2016.0116
·
Folia Cardiologica 2016;11(6):563-566.

open access

Vol 11, No 6 (2016)
Cardiac Surgery
Published online: 2017-01-17

Abstract

The myxoma makes 80–90% of benign cardiac neoplasms. The first symptom in 50% of patients is an embolism resulting from relocation of tumor fragments or blood clots into the bloodstream. Elevated values of acute phase proteins in these patients are results of non-specific immune response to an antigen causing the disease. Interleukin 6 (IL-6) plays a role in this reaction, modifying inflammatory response by: influence on lymphocyte T differentiation, lymphocyte B to plasmocyte transformation, and stimulation of the liver to produce acute phase proteins. Elevated IL-6 is found in 80% of patients with diagnosed myxoma, which causes it to be an important marker in diagnostic and post-operational monitoring. The role in non-specific inflammatory response played by IL-6 in myxoma and autoimmune disorders was a cause of many diagnostic mistakes. Available literature does not suggest a coincidence of cardiac myxoma and systemic sclerosis. This is why we would like to present a case report, with special regard to correlation between IL-6 values and activity/stage of diagnosed disorders.

Abstract

The myxoma makes 80–90% of benign cardiac neoplasms. The first symptom in 50% of patients is an embolism resulting from relocation of tumor fragments or blood clots into the bloodstream. Elevated values of acute phase proteins in these patients are results of non-specific immune response to an antigen causing the disease. Interleukin 6 (IL-6) plays a role in this reaction, modifying inflammatory response by: influence on lymphocyte T differentiation, lymphocyte B to plasmocyte transformation, and stimulation of the liver to produce acute phase proteins. Elevated IL-6 is found in 80% of patients with diagnosed myxoma, which causes it to be an important marker in diagnostic and post-operational monitoring. The role in non-specific inflammatory response played by IL-6 in myxoma and autoimmune disorders was a cause of many diagnostic mistakes. Available literature does not suggest a coincidence of cardiac myxoma and systemic sclerosis. This is why we would like to present a case report, with special regard to correlation between IL-6 values and activity/stage of diagnosed disorders.

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Keywords

myxoma, interleukin 6

About this article
Title

Right atrial myxoma in a patient with systemic sclerosis: a paraneoplastic syndrome or the coexistence of two diseases connected to increase in interleukin 6

Journal

Folia Cardiologica

Issue

Vol 11, No 6 (2016)

Pages

563-566

Published online

2017-01-17

DOI

10.5603/FC.2016.0116

Bibliographic record

Folia Cardiologica 2016;11(6):563-566.

Keywords

myxoma
interleukin 6

Authors

Małgorzata Peregud-Pogorzelska
Beata Trzcińska-Budkiewicz
Jarosław Kaźmierczak
Maciej Wielusiński
Marek Zieliński
Marek Brzosko

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