open access

Vol 11, No 3 (2016)
Original Papers
Published online: 2016-07-13
Get Citation

Obesity is independently associated with changes in cardiac function in young healthy males

Paweł Zalewski, Anna Grażyna Bitner, James Frith, Maciej Siński, Joanna Pawlak, Jacek Klawe, Małgorzata Tafil-Klawe, Julia Newton
DOI: 10.5603/FC.2016.0027
·
Folia Cardiologica 2016;11(3):171-177.

open access

Vol 11, No 3 (2016)
Original Papers
Published online: 2016-07-13

Abstract

Introduction. Obesity among young people has increased dramatically worldwide, and the prevalence continues to increase. Studies performed in both adults and children have confirmed that abnormalities of cardiac function and autonomic nervous system are present in those with obesity and might explain at least in part the increased mortality seen in those with obesity.

Materials and methods. The present study explores hemodynamic, autonomic and cardiovascular function in a cohort of well-characterized young men with obesity and compared these measures to those from a cohort of men of comparable age without obesity. Subjects underwent examination using Task Force® Monitor non-invasive assessment of the cardiovascular functions.

Results. The obesity group had a significantly higher resting heart rate (74.3 ± 11.8 vs. 56.0 ± 8.9 n/min, p < 0.0001), systolic (128.1 ± 9.4 vs. 114.3 ± 7.0 mm Hg, p < 0.0001) and diastolic (85.1 ± 8.2 vs. 70.7 ± 6.2 mm Hg, p < 0.0001) blood pressure compared to the age- and sex-matched, non-obesity group. This was coupled with significantly reduced stroke volume (81.3 ± 22.7 vs. 112.8 ± 20.3 ml, p < 0.0001), cardiac output (5.9 ± 1.5 vs. 6.2 ± 1.4 l/min; p < 0.0001) thoracic fluid content (28.5 ± 3.3 vs. 36.0 ± 3.3 1/Ohm, p < 0.0001) and contractility parameters, index of contractility (31.7 ± 12.9 vs. 68.8 ± 16.1 1000/s, p < 0.0001) and Heather index (0.1 ± 0.0 vs. 0.3 ± 0.0 1/s2, p < 0.0001).

Discussion. Our results confirm that obesity is associated with sub-clinical and cardiovascular abnormalities that can be identified using non-invasive measures. The differences identified in those with obesity were in young and healthy individuals. It will be important to determine whether these findings can be used to predict future clinical abnormalities.

Abstract

Introduction. Obesity among young people has increased dramatically worldwide, and the prevalence continues to increase. Studies performed in both adults and children have confirmed that abnormalities of cardiac function and autonomic nervous system are present in those with obesity and might explain at least in part the increased mortality seen in those with obesity.

Materials and methods. The present study explores hemodynamic, autonomic and cardiovascular function in a cohort of well-characterized young men with obesity and compared these measures to those from a cohort of men of comparable age without obesity. Subjects underwent examination using Task Force® Monitor non-invasive assessment of the cardiovascular functions.

Results. The obesity group had a significantly higher resting heart rate (74.3 ± 11.8 vs. 56.0 ± 8.9 n/min, p < 0.0001), systolic (128.1 ± 9.4 vs. 114.3 ± 7.0 mm Hg, p < 0.0001) and diastolic (85.1 ± 8.2 vs. 70.7 ± 6.2 mm Hg, p < 0.0001) blood pressure compared to the age- and sex-matched, non-obesity group. This was coupled with significantly reduced stroke volume (81.3 ± 22.7 vs. 112.8 ± 20.3 ml, p < 0.0001), cardiac output (5.9 ± 1.5 vs. 6.2 ± 1.4 l/min; p < 0.0001) thoracic fluid content (28.5 ± 3.3 vs. 36.0 ± 3.3 1/Ohm, p < 0.0001) and contractility parameters, index of contractility (31.7 ± 12.9 vs. 68.8 ± 16.1 1000/s, p < 0.0001) and Heather index (0.1 ± 0.0 vs. 0.3 ± 0.0 1/s2, p < 0.0001).

Discussion. Our results confirm that obesity is associated with sub-clinical and cardiovascular abnormalities that can be identified using non-invasive measures. The differences identified in those with obesity were in young and healthy individuals. It will be important to determine whether these findings can be used to predict future clinical abnormalities.

Get Citation

Keywords

obesity, functionally single ventricle, Fontan procedure, congenital heart disease, tissue Doppler imaging, echocardiography

About this article
Title

Obesity is independently associated with changes in cardiac function in young healthy males

Journal

Folia Cardiologica

Issue

Vol 11, No 3 (2016)

Pages

171-177

Published online

2016-07-13

DOI

10.5603/FC.2016.0027

Bibliographic record

Folia Cardiologica 2016;11(3):171-177.

Keywords

obesity
functionally single ventricle
Fontan procedure
congenital heart disease
tissue Doppler imaging
echocardiography

Authors

Paweł Zalewski
Anna Grażyna Bitner
James Frith
Maciej Siński
Joanna Pawlak
Jacek Klawe
Małgorzata Tafil-Klawe
Julia Newton

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

 

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl