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Vol 10, No 5 (2015)
Young Cardiology
Published online: 2015-10-28
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Are there any clinical associations with homocysteine and glycine plasma levels in patients with atrial fibrillation?

Ekaterina Sergeewna Yatskevich, Victor Alexandrovich Snezhitskiy, Alexandr Vasilevich Naumov, Evgeniy Mihajlovich Doroshenko, Vitaliy Jurevich Smirnov, Tamara Sergeevna Dolgoshej, Alexandr Jurevich Rubinskij
DOI: 10.5603/FC.2015.0062
·
Folia Cardiologica 2015;10(5):323-329.

open access

Vol 10, No 5 (2015)
Young Cardiology
Published online: 2015-10-28

Abstract

Introduction. Atrial fibrillation (AF) is constantly associated with a complex of various factors that create a diversity of pathophysiological variants due to phenomenon of atrial remodelling. The aim of the study was to investigate clinical associations with plasma homocysteine (Hcy) and glycine (Gly) levels in patients with paroxysmal and persistent AF.

Materials and methods. The study included 94 patients with ischaemic heart disease and/or hypertension without significant structural myocardial damage — 48 subjects with paroxysmal AF (group 1) and 27 subjects with persistent AF (group 2). Control group consisted of 19 patients without history of AF. Echocardiography was performed to assess left atrium (LA) size and function. Plasma levels of Hcy and Gly were measured.

Results. Patients with AF had significantly increased total plasma Hcy level. In group 2 there was a significant correlation between Hcy plasma level and LA-size. The Gly level > 349 μmol/L was found to be associated with a greater AF duration and was significantly more often in patients with AF existing for more than four years. Patients with Gly plasma level > 309 μmol/L and total Hcy plasma > 11.02 μmol/L showed significantly increased frequency of AF. Patients without AF showed Hcy plasma level < 11 μmol/L significantly more frequently (0% vs 29%) (р = 0.005).

Conclusion. There is an association between Hcy and Gly levels, atrial remodelling and the clinical course in patients with AF. It can be assumed that in a higher level of Hcy, increased Gly level may serve as a predictor of more pronounced structural and functional changes in the atria, but in such case it acts as a protective mechanism.

Abstract

Introduction. Atrial fibrillation (AF) is constantly associated with a complex of various factors that create a diversity of pathophysiological variants due to phenomenon of atrial remodelling. The aim of the study was to investigate clinical associations with plasma homocysteine (Hcy) and glycine (Gly) levels in patients with paroxysmal and persistent AF.

Materials and methods. The study included 94 patients with ischaemic heart disease and/or hypertension without significant structural myocardial damage — 48 subjects with paroxysmal AF (group 1) and 27 subjects with persistent AF (group 2). Control group consisted of 19 patients without history of AF. Echocardiography was performed to assess left atrium (LA) size and function. Plasma levels of Hcy and Gly were measured.

Results. Patients with AF had significantly increased total plasma Hcy level. In group 2 there was a significant correlation between Hcy plasma level and LA-size. The Gly level > 349 μmol/L was found to be associated with a greater AF duration and was significantly more often in patients with AF existing for more than four years. Patients with Gly plasma level > 309 μmol/L and total Hcy plasma > 11.02 μmol/L showed significantly increased frequency of AF. Patients without AF showed Hcy plasma level < 11 μmol/L significantly more frequently (0% vs 29%) (р = 0.005).

Conclusion. There is an association between Hcy and Gly levels, atrial remodelling and the clinical course in patients with AF. It can be assumed that in a higher level of Hcy, increased Gly level may serve as a predictor of more pronounced structural and functional changes in the atria, but in such case it acts as a protective mechanism.

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Keywords

atrial fibrillation, homocysteine, glycine, fibrosis, left atrium, echocardiography, structural and functional remodelling

About this article
Title

Are there any clinical associations with homocysteine and glycine plasma levels in patients with atrial fibrillation?

Journal

Folia Cardiologica

Issue

Vol 10, No 5 (2015)

Pages

323-329

Published online

2015-10-28

DOI

10.5603/FC.2015.0062

Bibliographic record

Folia Cardiologica 2015;10(5):323-329.

Keywords

atrial fibrillation
homocysteine
glycine
fibrosis
left atrium
echocardiography
structural and functional remodelling

Authors

Ekaterina Sergeewna Yatskevich
Victor Alexandrovich Snezhitskiy
Alexandr Vasilevich Naumov
Evgeniy Mihajlovich Doroshenko
Vitaliy Jurevich Smirnov
Tamara Sergeevna Dolgoshej
Alexandr Jurevich Rubinskij

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