open access
The role of vitamin D in women with Hashimoto’s thyroiditis
- Department of Endocrinology and Diabetology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland
- Cardiometabolic Centre Gierach-Med., Bydgoszcz, Poland
open access
Abstract
Introduction: Autoimmune thyroid diseases (AITD), including Hashimoto’s thyroiditis (HT), are the most common organ specific autoimmune disorders. Vitamin D (vit-D) is a steroid molecule, mainly produced in the skin, which regulates the expression of many genes.
The vitamin D receptor (VDR) is found in most tissues and cells in the body. Many studies suggests that vit-D deficiency, which is common worldwide, could also play an important role in autoimmune diseases, including HT. The aim of our study was to show the potential differences in vit-D levels between healthy women and individuals with hypothyroidism and HT. Additionally, we assessed the correlation between vit-D concentration and the level of TSH and anti-thyroid antibodies in females diagnosed with HT.
Material and methods: The study group included 370 subjects. The group was divided into 3 subgroups: (125 — healthy individuals, 111 — hypothyreosis, 134 — HT). Anthropometric measurements including height and weight were obtained in all participants. Body mass index (BMI) was calculated as body weight (in kilograms) divided by the square of body height (in metres). The measurement of the thyroid gland was performed using an ultrasound scan with a 10-MHz linear probe by one endocrinologist (Vivid S60N).
Results: We noticed that a lower level of vit-D was connected with a higher level of TSH in each subgroup. There was also strong, negative correlation between TSH and vit-D levels in all the study groups. Moreover, there was a weak, negative correlation between antithyroid peroxidase antibody (anti-TPO) and antithyroglobulin antibody (anti-TG) and vit-D levels in females with HT regardless of vit-D status: < 20 ng/mL, 20–30 ng/mL, and > 30 ng/mL.
Conclusions: To our knowledge, the current study is the first in Poland to compare vit-D status in healthy patients and patients with hypothyroidism, taking into account the level of antibodies (anti-TPO and anti-TG). The results of our study suggest that vit-D supplementation in patients with hypothyroidism, especially in the course of AITD, although determining its optimal, safe dose requires further research.
Abstract
Introduction: Autoimmune thyroid diseases (AITD), including Hashimoto’s thyroiditis (HT), are the most common organ specific autoimmune disorders. Vitamin D (vit-D) is a steroid molecule, mainly produced in the skin, which regulates the expression of many genes.
The vitamin D receptor (VDR) is found in most tissues and cells in the body. Many studies suggests that vit-D deficiency, which is common worldwide, could also play an important role in autoimmune diseases, including HT. The aim of our study was to show the potential differences in vit-D levels between healthy women and individuals with hypothyroidism and HT. Additionally, we assessed the correlation between vit-D concentration and the level of TSH and anti-thyroid antibodies in females diagnosed with HT.
Material and methods: The study group included 370 subjects. The group was divided into 3 subgroups: (125 — healthy individuals, 111 — hypothyreosis, 134 — HT). Anthropometric measurements including height and weight were obtained in all participants. Body mass index (BMI) was calculated as body weight (in kilograms) divided by the square of body height (in metres). The measurement of the thyroid gland was performed using an ultrasound scan with a 10-MHz linear probe by one endocrinologist (Vivid S60N).
Results: We noticed that a lower level of vit-D was connected with a higher level of TSH in each subgroup. There was also strong, negative correlation between TSH and vit-D levels in all the study groups. Moreover, there was a weak, negative correlation between antithyroid peroxidase antibody (anti-TPO) and antithyroglobulin antibody (anti-TG) and vit-D levels in females with HT regardless of vit-D status: < 20 ng/mL, 20–30 ng/mL, and > 30 ng/mL.
Conclusions: To our knowledge, the current study is the first in Poland to compare vit-D status in healthy patients and patients with hypothyroidism, taking into account the level of antibodies (anti-TPO and anti-TG). The results of our study suggest that vit-D supplementation in patients with hypothyroidism, especially in the course of AITD, although determining its optimal, safe dose requires further research.
Keywords
vitamin D; Hashimoto’s thyroiditis; hypothyreosis
Title
The role of vitamin D in women with Hashimoto’s thyroiditis
Journal
Issue
Article type
Original paper
Pages
176-180
Published online
2023-03-14
Page views
2532
Article views/downloads
742
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2023;74(2):176-180.
Keywords
vitamin D
Hashimoto’s thyroiditis
hypothyreosis
Authors
Marcin Gierach
Roman Junik
- Klecha AJ, Barreiro Arcos ML, Frick L, et al. Immune-endocrine interactions in autoimmune thyroid diseases. Neuroimmunomodulation. 2008; 15(1): 68–75.
- Fountoulakis S, Tsatsoulis A. On the pathogenesis of autoimmune thyroid disease: a unifying hypothesis. Clin Endocrinol (Oxf). 2004; 60(4): 397–409.
- Antonelli A, Ferrari SM, Corrado A, et al. Autoimmune thyroid disorders. Autoimmun Rev. 2015; 14(2): 174–180.
- Makariou S, Liberopoulos EN, Elisaf M, et al. Novel roles of vitamin D in disease: what is new in 2011? Eur J Intern Med. 2011; 22(4): 355–362.
- Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357(3): 266–281.
- Nair R, Maseeh A. Vitamin D: The "sunshine" vitamin. J Pharmacol Pharmacother. 2012; 3(2): 118–126.
- Verstuyf A, Carmeliet G, Bouillon R, et al. Vitamin D: a pleiotropic hormone. Kidney Int. 2010; 78(2): 140–145.
- Bizzaro G, Shoenfeld Y. Vitamin D and thyroid autoimmune diseases: the known and the obscure. Immunol Res. 2015; 61(1-2): 107–109.
- Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009; 94(1): 26–34.
- D'Aurizio F, Villalta D, Metus P, et al. Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases? Autoimmun Rev. 2015; 14(5): 363–369.
- Tamer G, Mesçi B. Role of Vitamin D in the Immune System. Turk J Endocrinol Metab. 2013; 17(1): 5–7.
- Prietl B, Treiber G, Pieber TR, et al. Vitamin D and immune function. Nutrients. 2013; 5(7): 2502–2521.
- Yang CY, Leung PSC, Adamopoulos IE, et al. The implication of vitamin D and autoimmunity: a comprehensive review. Clin Rev Allergy Immunol. 2013; 45(2): 217–226.
- Kim D. The Role of Vitamin D in Thyroid Diseases. Int J Mol Sci. 2017; 18(9).
- Pichler J, Gerstmayr M, Szépfalusi Z, et al. 1 alpha,25(OH)2D3 inhibits not only Th1 but also Th2 differentiation in human cord blood T cells. Pediatr Res. 2002; 52(1): 12–18.
- Joshi S, Pantalena LC, Liu XK, et al. 1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol Cell Biol. 2011; 31(17): 3653–3669.
- Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7): 1911–1930.
- Kivity S, Agmon-Levin N, Zisappl M, et al. Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol. 2011; 8(3): 243–247.
- Cvek M, Kaličanin D, Barić A, et al. Vitamin D and Hashimoto's Thyroiditis: Observations from CROHT Biobank. Nutrients. 2021; 13(8).
- Kim D. Low vitamin D status is associated with hypothyroid Hashimoto's thyroiditis. Hormones (Athens). 2016; 15(3): 385–393.
- Wang J, Lv S, Chen G, et al. Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients. 2015; 7(4): 2485–2498.
- Tamer G, Arik S, Tamer I, et al. Relative vitamin D insufficiency in Hashimoto's thyroiditis. Thyroid. 2011; 21(8): 891–896.
- Bozkurt NC, Karbek B, Ucan B, et al. The association between severity of vitamin D deficiency and Hashimoto's thyroiditis. Endocr Pract. 2013; 19(3): 479–484.
- Shin DY, Kim KJ, Kim D, et al. Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis. Yonsei Med J. 2014; 55(2): 476–481.
- Unal AD, Tarcin O, Parildar H, et al. Vitamin D deficiency is related to thyroid antibodies in autoimmune thyroiditis. Cent Eur J Immunol. 2014; 39(4): 493–497.
- Wang X, Zynat J, Guo Y, et al. Low Serum Vitamin D Is Associated with Anti-Thyroid-Globulin Antibody in Female Individuals. Int J Endocrinol. 2015; 2015: 285290.
- Choi YMi, Kim WGu, Kim TY, et al. Low levels of serum vitamin D3 are associated with autoimmune thyroid disease in pre-menopausal women. Thyroid. 2014; 24(4): 655–661.
- De Re, Vianale L, De Re, et al. Vitamin D and autoimmune thyroid disease: Preliminary results. Thyroid. 2013; 23: A81–A82.