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open access

Vol 71, No 2 (2020)
Original paper
Submitted: 2019-11-25
Accepted: 2020-02-02
Published online: 2020-03-10
View PDF Download PDF file Supp./Additional Files [1]
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Pituitary tumours — a large retrospective single-centre study of over 2300 cases. Experience of a tertiary reference centre

Beata Rak123, Maria Maksymowicz4, Tomasz M. Grzywa5, Emir Sajjad62, Monika Pękul4, Paweł Włodarski5, Grzegorz Zieliński6
DOI: 10.5603/EP.a2020.0011
·
Pubmed: 32154573
·
Endokrynol Pol 2020;71(2):116-125.
Affiliations
  1. Department of Internal Diseases and Endocrinology, Public Central Teaching Hospital, Medical University of Warsaw, Poland, Poland
  2. Department of Histology and Embryology, Centre for Preclinical Research, Medical University of Warsaw, Poland
  3. Postgraduate School of Molecular Medicine, Medical University of Warsaw, Poland
  4. Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
  5. Department of Methodology, Center for Preclinical Research, Medical University of Warsaw, Poland
  6. Department of Neurosurgery, Military Institute of Medicine, Warsaw, Poland

open access

Vol 71, No 2 (2020)
Original Paper
Submitted: 2019-11-25
Accepted: 2020-02-02
Published online: 2020-03-10

Abstract

Introduction: Pituitary adenomas (PAs), also known as a pituitary neuroendocrine tumours (PitNET), are usually benign tumours of the anterior lobe of the pituitary gland and account for the third most common intracranial neoplasm. The most common type of pituitary adenoma is lactotroph adenoma, in which dopamine agonists are the first-line treatment. Nevertheless, in selected cases surgery or even radiotherapy may be required. In the current study, we aimed to analyse all patients who underwent surgery due to intrasellar mass in order to evaluate frequency of particular pituitary tumours, clinical diagnosis, and pathology findings.

Material and methods: We retrospectively analysed all cases of patients consecutively operated due to intrasellar mass between 1st January 2010 and 31st December 2018 at the Department of Neurosurgery, Military Institute of Medicine in Warsaw, Poland.

Results: Our database included 2348 cases: 1390 women (59.2%) and 958 men (40.8%). The mean age for women was 48.4 years (SD ± 15.72; median 49) and for men 50.9 years (SD ± 14.94; median 53). In our cohort we found: 869 gonadotroph and null cell adenomas, 751 somatotroph and mammosomatotroph adenomas, 386 corticotroph adenomas, 71 plurihormonal adenomas, 59 craniopharyngiomas, 44 lactotroph adenomas, 18 purely thyrotroph adenomas, and other rare cases of pituitary tumours including one pituitary carcinoma metastasising to the liver (corticotroph origin).

Conclusions: We provide a comprehensive analysis of both clinical and pathological findings of the largest cohort of patients operated on for pituitary adenomas in one tertiary reference centre. To the best of our knowledge, this is the largest up-to-date published analysis in our country. 

Abstract

Introduction: Pituitary adenomas (PAs), also known as a pituitary neuroendocrine tumours (PitNET), are usually benign tumours of the anterior lobe of the pituitary gland and account for the third most common intracranial neoplasm. The most common type of pituitary adenoma is lactotroph adenoma, in which dopamine agonists are the first-line treatment. Nevertheless, in selected cases surgery or even radiotherapy may be required. In the current study, we aimed to analyse all patients who underwent surgery due to intrasellar mass in order to evaluate frequency of particular pituitary tumours, clinical diagnosis, and pathology findings.

Material and methods: We retrospectively analysed all cases of patients consecutively operated due to intrasellar mass between 1st January 2010 and 31st December 2018 at the Department of Neurosurgery, Military Institute of Medicine in Warsaw, Poland.

Results: Our database included 2348 cases: 1390 women (59.2%) and 958 men (40.8%). The mean age for women was 48.4 years (SD ± 15.72; median 49) and for men 50.9 years (SD ± 14.94; median 53). In our cohort we found: 869 gonadotroph and null cell adenomas, 751 somatotroph and mammosomatotroph adenomas, 386 corticotroph adenomas, 71 plurihormonal adenomas, 59 craniopharyngiomas, 44 lactotroph adenomas, 18 purely thyrotroph adenomas, and other rare cases of pituitary tumours including one pituitary carcinoma metastasising to the liver (corticotroph origin).

Conclusions: We provide a comprehensive analysis of both clinical and pathological findings of the largest cohort of patients operated on for pituitary adenomas in one tertiary reference centre. To the best of our knowledge, this is the largest up-to-date published analysis in our country. 

Full Text:

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Keywords

pituitary adenomas; Pas; pituitary neuroendocrine tumours; PitNET; retrospective single-centre analysis

Supp./Additional Files (1)
FIGURE S1. The proportion of silent types of pituitary adenomas among the most common hormonally active PAs recorded in our database. The difference of silent type occurrence was not statistically significant between two groups measured by the Chi-squared
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About this article
Title

Pituitary tumours — a large retrospective single-centre study of over 2300 cases. Experience of a tertiary reference centre

Journal

Endokrynologia Polska

Issue

Vol 71, No 2 (2020)

Article type

Original paper

Pages

116-125

Published online

2020-03-10

Page views

2068

Article views/downloads

1161

DOI

10.5603/EP.a2020.0011

Pubmed

32154573

Bibliographic record

Endokrynol Pol 2020;71(2):116-125.

Keywords

pituitary adenomas
Pas
pituitary neuroendocrine tumours
PitNET
retrospective single-centre analysis

Authors

Beata Rak
Maria Maksymowicz
Tomasz M. Grzywa
Emir Sajjad
Monika Pękul
Paweł Włodarski
Grzegorz Zieliński

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