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open access

Vol 74, No 2 (2023)
Review paper
Submitted: 2022-07-07
Accepted: 2022-09-13
Published online: 2023-04-11
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Thyroid organoids: Advances and applications

Jinlu Zhao1, Yi Ren1, Zhenzhong Ge2, Xingyu Zhao1, Wang Li1, He Wang3, Meng Jiang4
DOI: 10.5603/EP.a2023.0019
·
Pubmed: 37039493
·
Endokrynol Pol 2023;74(2):121-127.
Affiliations
  1. Department of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China
  2. The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Nanjing, China
  3. Department of Pathology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China
  4. Faculty of Computing, Harbin Institute of Technology, Harbin, China

open access

Vol 74, No 2 (2023)
Review Article
Submitted: 2022-07-07
Accepted: 2022-09-13
Published online: 2023-04-11

Abstract

Organoids are derived from stem cells under three-dimensional culture conditions through self-assembly, and they can recapitulate the structural and functional characteristics of organs in vivo during culture. Organoids can be generated from both normal and malignant tissues. Those derived from normal tissues are widely used in the field of regenerative medicine. Meanwhile, tumour-derived organoids retain the phenotypic heterogeneity and atypia of the primary tumour, thereby providing a reliable in vitro model for the study of tumour pathogenesis and treatment. The thyroid gland is one of the most important endocrine organs regulating the body’s energy metabolism and growth; however, it is also associated with a high incidence of malignancy. Organoid is an effective tool for thyroid research.

Thyroid tumour-derived organoids can inherit the histopathological properties of primary tumours, and thyroid tissue-derived organoids can form follicular structures and secrete thyroid hormones. The above characteristics of organoids provide a reliable way to study the mechanism of thyroid genesis and tumour development in vitro. In this review, we focus on current knowledge and strategies for the establishment of thyroid organoids in thyroid regeneration and tumour research aiming to increase our understanding of the pathogenesis of thyroid tumours and the regenerative treatment of patients with hypothyroidism.

Abstract

Organoids are derived from stem cells under three-dimensional culture conditions through self-assembly, and they can recapitulate the structural and functional characteristics of organs in vivo during culture. Organoids can be generated from both normal and malignant tissues. Those derived from normal tissues are widely used in the field of regenerative medicine. Meanwhile, tumour-derived organoids retain the phenotypic heterogeneity and atypia of the primary tumour, thereby providing a reliable in vitro model for the study of tumour pathogenesis and treatment. The thyroid gland is one of the most important endocrine organs regulating the body’s energy metabolism and growth; however, it is also associated with a high incidence of malignancy. Organoid is an effective tool for thyroid research.

Thyroid tumour-derived organoids can inherit the histopathological properties of primary tumours, and thyroid tissue-derived organoids can form follicular structures and secrete thyroid hormones. The above characteristics of organoids provide a reliable way to study the mechanism of thyroid genesis and tumour development in vitro. In this review, we focus on current knowledge and strategies for the establishment of thyroid organoids in thyroid regeneration and tumour research aiming to increase our understanding of the pathogenesis of thyroid tumours and the regenerative treatment of patients with hypothyroidism.

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Keywords

organoids; thyroid; regenerative medicine; tumour research

About this article
Title

Thyroid organoids: Advances and applications

Journal

Endokrynologia Polska

Issue

Vol 74, No 2 (2023)

Article type

Review paper

Pages

121-127

Published online

2023-04-11

Page views

2999

Article views/downloads

1106

DOI

10.5603/EP.a2023.0019

Pubmed

37039493

Bibliographic record

Endokrynol Pol 2023;74(2):121-127.

Keywords

organoids
thyroid
regenerative medicine
tumour research

Authors

Jinlu Zhao
Yi Ren
Zhenzhong Ge
Xingyu Zhao
Wang Li
He Wang
Meng Jiang

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