open access

Vol 73, No 1 (2022)
Original paper
Submitted: 2021-09-08
Accepted: 2021-11-02
Published online: 2022-01-31
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Efficacy and safety of SGLT-2i in overweight/obese, non-diabetic individuals: a meta-analysis of randomized controlled trials

Yetan Shi1, Yuexiu Si2, Rongrong Fu3, Mengting Zhang1, Ke Jiang1, Wei Dai1, Jingyi Shen1, Xiangyuan Li1, Yuan Yuan4
·
Pubmed: 35119088
·
Endokrynol Pol 2022;73(1):71-80.
Affiliations
  1. The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
  2. School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
  3. The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
  4. Department of General Surgery, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China

open access

Vol 73, No 1 (2022)
Original Paper
Submitted: 2021-09-08
Accepted: 2021-11-02
Published online: 2022-01-31

Abstract

Introduction: Sodium-glucose cotransporter 2 inhibitor (SGLT-2i) has been shown to decrease blood glucose levels in type 2 diabetes mellitus (T2DM) patients and potentially yield additional benefits in weight loss. This meta-analysis aimed to investigate the efficacy and safety of giving SGLT-2i to overweight/obese, non-diabetic individuals.

Material and methods: The search was underpinned by PubMed, Cochrane Central Register of Controlled Trials, Web of Science, and Springer to identify English-language papers on randomized controlled trials (RCTs) on the use of SGLT-2i in overweight/obese, nondiabetic individuals published in and before March 2021, to study its effectiveness and safety. Results were evaluated by weighted mean difference (WMD), standardized mean difference (SMD), risk ratio (RR), and 95% confidence interval (CI).

Results: We reviewed 13 papers and compared the SGLT-2i group with the control group (other drugs and placebo) and found that SGLT-2i reduced weight (WMD = –1.33, p = 0.002) and waist circumference (WMD = –1.94, p = 0.03) in overweight/obese, non-diabetic individuals. The use of SGLT-2i is more effective than other interventions in terms of weight loss ≥ 5% (RR = 2.04, p < 0.001), but not in terms of weight loss ≥ 10% (RR = 1.83, p = 0.22). In addition, there were no significant changes in other metabolic parameters, like fasting plasma glucose (FPG), lipids, blood pressure, etc. SGLT-2i increased the risk of infections in urinary tract (RR = 1.91, p = 0.009) and
reproductive system (RR = 4.09, p < 0.001).

Conclusions: SGLT-2i is a promising candidate to reduce weight and waist circumference to a limited extent in overweight/obese, nondiabetic individuals. Generally, it is safe and effective. However, it potentially increased the risk of urogenital infections, which cannot be ignored.

Abstract

Introduction: Sodium-glucose cotransporter 2 inhibitor (SGLT-2i) has been shown to decrease blood glucose levels in type 2 diabetes mellitus (T2DM) patients and potentially yield additional benefits in weight loss. This meta-analysis aimed to investigate the efficacy and safety of giving SGLT-2i to overweight/obese, non-diabetic individuals.

Material and methods: The search was underpinned by PubMed, Cochrane Central Register of Controlled Trials, Web of Science, and Springer to identify English-language papers on randomized controlled trials (RCTs) on the use of SGLT-2i in overweight/obese, nondiabetic individuals published in and before March 2021, to study its effectiveness and safety. Results were evaluated by weighted mean difference (WMD), standardized mean difference (SMD), risk ratio (RR), and 95% confidence interval (CI).

Results: We reviewed 13 papers and compared the SGLT-2i group with the control group (other drugs and placebo) and found that SGLT-2i reduced weight (WMD = –1.33, p = 0.002) and waist circumference (WMD = –1.94, p = 0.03) in overweight/obese, non-diabetic individuals. The use of SGLT-2i is more effective than other interventions in terms of weight loss ≥ 5% (RR = 2.04, p < 0.001), but not in terms of weight loss ≥ 10% (RR = 1.83, p = 0.22). In addition, there were no significant changes in other metabolic parameters, like fasting plasma glucose (FPG), lipids, blood pressure, etc. SGLT-2i increased the risk of infections in urinary tract (RR = 1.91, p = 0.009) and
reproductive system (RR = 4.09, p < 0.001).

Conclusions: SGLT-2i is a promising candidate to reduce weight and waist circumference to a limited extent in overweight/obese, nondiabetic individuals. Generally, it is safe and effective. However, it potentially increased the risk of urogenital infections, which cannot be ignored.

Get Citation

Keywords

SGLT-2i; overweight; obese; weight reduction; non-diabetic; meta-analysis

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Title

Efficacy and safety of SGLT-2i in overweight/obese, non-diabetic individuals: a meta-analysis of randomized controlled trials

Journal

Endokrynologia Polska

Issue

Vol 73, No 1 (2022)

Article type

Original paper

Pages

71-80

Published online

2022-01-31

Page views

7313

Article views/downloads

1129

DOI

10.5603/EP.a2021.0102

Pubmed

35119088

Bibliographic record

Endokrynol Pol 2022;73(1):71-80.

Keywords

SGLT-2i
overweight
obese
weight reduction
non-diabetic
meta-analysis

Authors

Yetan Shi
Yuexiu Si
Rongrong Fu
Mengting Zhang
Ke Jiang
Wei Dai
Jingyi Shen
Xiangyuan Li
Yuan Yuan

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