open access

Ahead of print
Clinical vignette
Submitted: 2021-07-10
Accepted: 2021-08-10
Published online: 2021-08-18
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Liver dysfunction and hypoglycemia as presentation of hypopituitarism in a child

Sara Fonseca12, Tiago Magalhães12, Beatriz Teixeira34, Lurdes Lisboa5, Esmeralda Rodrigues6, Eunice Trindade7, Sofia Ferreira8, Carla Costa8, Cíntia Castro-Correia28
DOI: 10.5603/EP.a2021.0079
·
Pubmed: 34647612
Affiliations
  1. Pediatrics Department, Centro Hospitalar Universitário São João, Porto, Portugal, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
  2. Department of Obstetrics, Gynecology, and Pediatrics, Faculty of Medicine, University of Porto, Porto, Portugal
  3. Pediatrics Department, Centro Materno Infantil do Norte, Porto, Portugal, Porto, Portugal
  4. Pediatrics Department, Centro Hospitalar De Trás-Os-Montes E Alto Douro, Portugal, Portugal
  5. Pediatric Intensive Care Unit, São João University Hospital Centre, Porto, Portugal, Portugal
  6. Reference Centre for Inborn Errors of Metabolism of São João University Hospital Centre, Porto, Portugal, Porto, Portugal
  7. Pediatric Gastroenterology Unit, Pediatrics Department, São João University Hospital Centre, Porto, Portugal, Porto, Portugal
  8. Pediatric Endocrinology Unit, Pediatrics Department, São João University Hospital Centre, Porto, Portugal, Porto, Portugal

open access

Ahead of print
Clinical Vignette
Submitted: 2021-07-10
Accepted: 2021-08-10
Published online: 2021-08-18

Abstract

In the presence of hypoglycemia and liver dysfunction in the neonatal period and/or during the first months of life, a myriad of etiologies should be considered. We herein report the case of a child with refractory hypoglycemia and severe liver dysfunction, highlighting the importance of a multidisciplinary and rapid investigation to obtain the final diagnosis.

Abstract

In the presence of hypoglycemia and liver dysfunction in the neonatal period and/or during the first months of life, a myriad of etiologies should be considered. We herein report the case of a child with refractory hypoglycemia and severe liver dysfunction, highlighting the importance of a multidisciplinary and rapid investigation to obtain the final diagnosis.

Get Citation

Keywords

Child; cholestatic jaundice; hypoglycemia; hypopituitarism; liver dysfunction

About this article
Title

Liver dysfunction and hypoglycemia as presentation of hypopituitarism in a child

Journal

Endokrynologia Polska

Issue

Ahead of print

Article type

Clinical vignette

Published online

2021-08-18

DOI

10.5603/EP.a2021.0079

Pubmed

34647612

Keywords

Child
cholestatic jaundice
hypoglycemia
hypopituitarism
liver dysfunction

Authors

Sara Fonseca
Tiago Magalhães
Beatriz Teixeira
Lurdes Lisboa
Esmeralda Rodrigues
Eunice Trindade
Sofia Ferreira
Carla Costa
Cíntia Castro-Correia

References (5)
  1. Cavarzere P, Biban P, Gaudino R, et al. Diagnostic pitfalls in the assessment of congenital hypopituitarism. J Endocrinol Invest. 2014; 37(12): 1201–1209.
  2. Braslavsky D, Keselman A, Chiesa A, et al. Diagnóstico de endocrinopatía congénita en neonatos con ictericia prolongada e hipoglucemia. An Pediatría. 2012; 76(3): 120–126.
  3. Karnsakul W, Sawathiparnich P, Nimkarn S, et al. Anterior pituitary hormone effects on hepatic functions in infants with congenital hypopituitarism. Ann Hepatol. 2007; 6(2): 97–103.
  4. Binder G, Martin DD, Kanther I, et al. The course of neonatal cholestasis in congenital combined pituitary hormone deficiency. J Pediatr Endocrinol Metab. 2007; 20(6): 695–702.
  5. Geffner ME. Hypopituitarism in childhood. Cancer Control. 2002; 9(3): 212–222.

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