open access

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Review paper
Submitted: 2021-07-06
Accepted: 2021-08-06
Published online: 2021-10-06
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The Outstanding Beneficial Roles of Irisin in Depressive Disorders

Sermin Algül1, Saadet Ilcin1, Oguz Ozcelik2
DOI: 10.5603/EP.a2021.0088
·
Pubmed: 34647610
Affiliations
  1. Van Yuzuncu Yil University, Faculty of Medicine, Department of Physiology, Van Yuzuncu Yil University, Faculty of Medicine, Department of Physiology, Van, Turkey, 65100 Van, Turkey
  2. Kastamonu University, Faculty of Medicine, Department of Physiology, Kastamonu University, Faculty of Medicine, Department of Physiology, 37100 Kastamonu, Turkey

open access

Ahead of print
Review Article
Submitted: 2021-07-06
Accepted: 2021-08-06
Published online: 2021-10-06

Abstract

Objective: Depression is a widely observed psychiatric disorder that affects a quite large number of people all around the world. A major depressive disorder (MDD) is a multifactorial disease that associated with fluctation in appetite, body weight, and energy situations in addition to serious mood problems. The aim of this review is concentrated to investigate possible link between energy regulatory hormones of irisin and depressive disorders. Methods: Irisin is a hormone that has significant contribution to the regulation of lipid and glucose metabolism in skeletal muscle and adipose tissue. Results: Irisin was also reported to have significant roles in central nervous system. In the literature, there are reports indicating the beneficial antidepressant role of irisin in MDD. Conclusions: It should be emphsesied that the antidepressive effects of exercise could be the results of exercise induced increased hormones of irisin.

Abstract

Objective: Depression is a widely observed psychiatric disorder that affects a quite large number of people all around the world. A major depressive disorder (MDD) is a multifactorial disease that associated with fluctation in appetite, body weight, and energy situations in addition to serious mood problems. The aim of this review is concentrated to investigate possible link between energy regulatory hormones of irisin and depressive disorders. Methods: Irisin is a hormone that has significant contribution to the regulation of lipid and glucose metabolism in skeletal muscle and adipose tissue. Results: Irisin was also reported to have significant roles in central nervous system. In the literature, there are reports indicating the beneficial antidepressant role of irisin in MDD. Conclusions: It should be emphsesied that the antidepressive effects of exercise could be the results of exercise induced increased hormones of irisin.

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Keywords

Irisin, Major depresivve disorders, FNDC5, Type 2 diabetes mellitus, Obesity

About this article
Title

The Outstanding Beneficial Roles of Irisin in Depressive Disorders

Journal

Endokrynologia Polska

Issue

Ahead of print

Article type

Review paper

Published online

2021-10-06

DOI

10.5603/EP.a2021.0088

Pubmed

34647610

Keywords

Irisin
Major depresivve disorders
FNDC5
Type 2 diabetes mellitus
Obesity

Authors

Sermin Algül
Saadet Ilcin
Oguz Ozcelik

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