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The effects of selenium supplementation on antibody titres in patients with Hashimoto’s thyroiditis
Affiliations- Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
- Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
open access
Abstract
Introduction: The objective of this study was to evaluate the effect of selenium supplementation on autoantibody titres, thyroid ultrasonography, and thyroid function in patients with Hashimoto’s thyroiditis (autoimmune thyroiditis) and normal thyroid reference range.
Material and methods: A total of 100 patients were given 200 ug/d selenium yeast orally, their thyroid function, levels of serum selenium, thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TGAb), and urine iodine were measured, and thyroid ultrasonography was performed before administration and three and six months afterwards, and the data were statistically analysed.
Results: The subjects exhibited a selenium deficiency before the administration of selenium, and the serum levels increased to moderate levels three and six months after the selenium supplementation (p < 0.05). The titres of TGAb decreased significantly in patients after six months of selenium supplementation (p < 0.05). In the high antibody group, TgAb decreased after 6 months compared with baseline (p = p < 0.05), and TPOAb decreased after 3 and 6 months of selenium supplementation compared with baseline (p < 0.05).
Conclusion: In patients with autoimmune thyroiditis and normal thyroid reference range, there was a general selenium deficiency, but after six months of treatment it was shown that selenium supplementation may be effective in reducing the titres of TGAb and TPOAb.
Abstract
Introduction: The objective of this study was to evaluate the effect of selenium supplementation on autoantibody titres, thyroid ultrasonography, and thyroid function in patients with Hashimoto’s thyroiditis (autoimmune thyroiditis) and normal thyroid reference range.
Material and methods: A total of 100 patients were given 200 ug/d selenium yeast orally, their thyroid function, levels of serum selenium, thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TGAb), and urine iodine were measured, and thyroid ultrasonography was performed before administration and three and six months afterwards, and the data were statistically analysed.
Results: The subjects exhibited a selenium deficiency before the administration of selenium, and the serum levels increased to moderate levels three and six months after the selenium supplementation (p < 0.05). The titres of TGAb decreased significantly in patients after six months of selenium supplementation (p < 0.05). In the high antibody group, TgAb decreased after 6 months compared with baseline (p = p < 0.05), and TPOAb decreased after 3 and 6 months of selenium supplementation compared with baseline (p < 0.05).
Conclusion: In patients with autoimmune thyroiditis and normal thyroid reference range, there was a general selenium deficiency, but after six months of treatment it was shown that selenium supplementation may be effective in reducing the titres of TGAb and TPOAb.
Keywords
selenium yeast; Hashimoto’s thyroiditis; thyroglobulin antibody; thyroid peroxidase antibody
Supp./Additional Files (1)
About this articleTitle
The effects of selenium supplementation on antibody titres in patients with Hashimoto’s thyroiditis
Journal
Issue
Article type
Brief communication
Pages
666-667
Published online
2021-08-06
Page views
5681
Article views/downloads
844
DOI
10.5603/EP.a2021.0074
Pubmed
Bibliographic record
Endokrynol Pol 2021;72(6):666-667.
Keywords
selenium yeast
Hashimoto’s thyroiditis
thyroglobulin antibody
thyroid peroxidase antibody
Authors
Lan-Feng Wang
Rong-Xin Sun
Chen-Fei Li
Xu-Hong Wang
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