open access

Ahead of print
Brief communication
Submitted: 2021-07-06
Accepted: 2021-07-17
Published online: 2021-08-06
Get Citation

The effects of selenium supplementation on antibody titers in patients with Hashimoto's thyroiditis

Lan-Feng Wang1, Rong-Xin Sun1, Chen-Fei Li1, Xu-Hong Wang1
DOI: 10.5603/EP.a2021.0074
·
Pubmed: 34378788
Affiliations
  1. Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, No. 82 of Xinhua South Road, Tongzhou District,, 101149 Beijing, China

open access

Ahead of print
Short communication
Submitted: 2021-07-06
Accepted: 2021-07-17
Published online: 2021-08-06

Abstract

Objective: To evaluate the effect of selenium supplementation on autoantibody titers, thyroid ultrasonography and thyroid function in patients with Hashimoto's thyroiditis (autoimmune thyroiditis) and normal thyroid reference range. Methods: A total of 100 patients were given 200 ug/d selenium yeast orally, their thyroid function, levels of serum selenium, thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TGAb) and urine iodine were measured and thyroid ultrasonography was performed before administration and three and six months afterwards, and the data were statistically analysed. Results: The subjects exhibited a selenium deficiency before the administration of selenium, and the serum levels increased to moderate levels three and six months after the selenium supplementation (p<0.05). The titers of TGAb decreased significantly in patients after six months of Selenium lack prevention measure(p<0.05). In the high antibody group, TgAb decreased after 6 months compared with baseline (P<0.05), and TPOAb decreased after 3 and 6 months of selenium supplementation compared with baseline (P<0.05). Conclusion: In patients with autoimmune thyroiditis and normal thyroid reference range, there was a general selenium deficiency but, after six months of treatment, it was shown that the Selenium lack prevention measure may be effective in reducing the titers of TGAb and TPOAb.

Abstract

Objective: To evaluate the effect of selenium supplementation on autoantibody titers, thyroid ultrasonography and thyroid function in patients with Hashimoto's thyroiditis (autoimmune thyroiditis) and normal thyroid reference range. Methods: A total of 100 patients were given 200 ug/d selenium yeast orally, their thyroid function, levels of serum selenium, thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TGAb) and urine iodine were measured and thyroid ultrasonography was performed before administration and three and six months afterwards, and the data were statistically analysed. Results: The subjects exhibited a selenium deficiency before the administration of selenium, and the serum levels increased to moderate levels three and six months after the selenium supplementation (p<0.05). The titers of TGAb decreased significantly in patients after six months of Selenium lack prevention measure(p<0.05). In the high antibody group, TgAb decreased after 6 months compared with baseline (P<0.05), and TPOAb decreased after 3 and 6 months of selenium supplementation compared with baseline (P<0.05). Conclusion: In patients with autoimmune thyroiditis and normal thyroid reference range, there was a general selenium deficiency but, after six months of treatment, it was shown that the Selenium lack prevention measure may be effective in reducing the titers of TGAb and TPOAb.

Get Citation

Keywords

selenium yeast; Hashimoto' s thyroiditis; Thyroglobulin antibody; Thyroid peroxidase antibody

About this article
Title

The effects of selenium supplementation on antibody titers in patients with Hashimoto's thyroiditis

Journal

Endokrynologia Polska

Issue

Ahead of print

Article type

Brief communication

Published online

2021-08-06

DOI

10.5603/EP.a2021.0074

Pubmed

34378788

Keywords

selenium yeast
Hashimoto's thyroiditis
Thyroglobulin antibody
Thyroid peroxidase antibody

Authors

Lan-Feng Wang
Rong-Xin Sun
Chen-Fei Li
Xu-Hong Wang

References (5)
  1. Caturegli P, De Remigis A, Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014; 13(4-5): 391–397.
  2. Vanderpump M. The epidemiology of thyroid disease. Br Med Bull. 2011; 99(1): 39–51.
  3. Rizzo M, Rossi RT, Bonaffini O, et al. Increased annual frequency of Hashimoto's thyroiditis between years 1988 and 2007 at a cytological unit of Sicily. Ann Endocrinol (Paris). 2010; 71(6): 525–534.
  4. Zhao H, Tian Y, Liu Z, et al. Correlation between iodine intake and thyroid disorders: a cross-sectional study from the South of China. Biol Trace Elem Res. 2014; 162(1-3): 87–94.
  5. Guastamacchia E, Giagulli VA, Licchelli B, et al. Selenium and Iodine in Autoimmune Thyroiditis. Endocr Metab Immune Disord Drug Targets. 2015; 15(4): 288–292.

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl