open access
Treatment of type 2 diabetes mellitus and risk of pancreatic cancer
, 2
Affiliations- Department of Physiology, Medyków 18, 40-752 Katowice, Poland
- Department of Gastrointestinal Surgery, Medical University of Silesia, Katowice, Poland
open access
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is the most common cancer of the exocrine part of the pancreas with poor prognosis. Up to 85% of PDAC patients are diagnosed with diabetes or hyperglycaemia at the time of diagnosis indicating that impaired glucose homeostasis is a common event in this cancer. A mechanism of association between PDAC and diabetes is very complex and still not fully understood. Currently, the various classes of anti-diabetic drugs are used in diabetes treatment. It is possible that specific types of anti-diabetic drugs for diabetes may have different impacts on pancreatic cancer development. Moreover, the intriguing question of whether diabetes can facilitate PDAC development remains unanswered. This paper presents the results of recent studies on the effect of the anti-diabetic treatment used on pancreatic cancer risk in diabetic patients.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is the most common cancer of the exocrine part of the pancreas with poor prognosis. Up to 85% of PDAC patients are diagnosed with diabetes or hyperglycaemia at the time of diagnosis indicating that impaired glucose homeostasis is a common event in this cancer. A mechanism of association between PDAC and diabetes is very complex and still not fully understood. Currently, the various classes of anti-diabetic drugs are used in diabetes treatment. It is possible that specific types of anti-diabetic drugs for diabetes may have different impacts on pancreatic cancer development. Moreover, the intriguing question of whether diabetes can facilitate PDAC development remains unanswered. This paper presents the results of recent studies on the effect of the anti-diabetic treatment used on pancreatic cancer risk in diabetic patients.
Keywords
pancreatic cancer; type 2 diabetes mellitus; anti-diabetic medication; pancreatic cancer risk
About this articleTitle
Treatment of type 2 diabetes mellitus and risk of pancreatic cancer
Journal
Issue
Article type
Review paper
Pages
395-401
Published online
2021-07-28
Page views
1307
Article views/downloads
974
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2021;72(4):395-401.
Keywords
pancreatic cancer
type 2 diabetes mellitus
anti-diabetic medication
pancreatic cancer risk
Authors
Edyta Olakowska
Marek Olakowski
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