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Original paper
Published online: 2021-06-08
Submitted: 2021-02-21
Accepted: 2021-05-16
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Determination of neuron-specific enolase in patients with midgut type tumor treated with somatostatin analogues

Paweł Gut, Agata Czarnywojtek, Nadia Sawicka - Gutaj, Kosma Woliński, Adam Maciejewski, Paweł Komarnicki, Marek Ruchała
DOI: 10.5603/EP.a2021.0060

open access

Ahead of print
Original Paper
Published online: 2021-06-08
Submitted: 2021-02-21
Accepted: 2021-05-16

Abstract

Abstract Introduction: The biochemical diagnosis of neuroendocrine tumors (NETs) uses assays of specific and nonspecific markers. Nonspecific markers include, among others, neuron-specific enolase (NSE). The aim of this study was to evaluate NSE in patients with midgut type tumors treated with somatostatin analogs. Material and methods: The study group of patients with NETs of the small intestine included 41 patients. The grade G1 was found in 19 cases, while G2 in the remaining 22. Liver metastases were found in all patients studied. The examined group of patients was treated with somatostatin analogues receiving octreotide LAR at a dose of 30mg. The control of biochemical parameters was performed every 3 months and imaging examinations every 6 months. Immuno - Biological Laboratories kit was used for determination of NSE concentration, where reference values were 12.5 - 25 ng/ml. Results: In the G1 group of patients, the mean value of NSE concentration was 54.88 ng/ml, while in the G2 group, the value was 119.56 ng/ml and was significantly higher than in the G1 group (p=0.003). In the determination of NSE concentration values according to the degree of liver involvement, in the group of patients with 10% liver involvement, the mean value of NSE concentration was 49.37 ng/ml, while in the group with 25% liver involvement, the value was 143.13 ng/ml (p < 0.001). In the analysis of NSE concentration assessment in patients with disease progression, the mean value was 129.65 ng/ml compared to the group with disease stabilization, where the mean NSE value was significantly lower and amounted to 52.61 ng/ml (p < 0.001). Conclusions: In our study, we observed that NSE concentration values were significantly higher among patients with NET midgut type tumor with histological grade G2 and in patients with 25% liver involvement and progression of the disease process.

Abstract

Abstract Introduction: The biochemical diagnosis of neuroendocrine tumors (NETs) uses assays of specific and nonspecific markers. Nonspecific markers include, among others, neuron-specific enolase (NSE). The aim of this study was to evaluate NSE in patients with midgut type tumors treated with somatostatin analogs. Material and methods: The study group of patients with NETs of the small intestine included 41 patients. The grade G1 was found in 19 cases, while G2 in the remaining 22. Liver metastases were found in all patients studied. The examined group of patients was treated with somatostatin analogues receiving octreotide LAR at a dose of 30mg. The control of biochemical parameters was performed every 3 months and imaging examinations every 6 months. Immuno - Biological Laboratories kit was used for determination of NSE concentration, where reference values were 12.5 - 25 ng/ml. Results: In the G1 group of patients, the mean value of NSE concentration was 54.88 ng/ml, while in the G2 group, the value was 119.56 ng/ml and was significantly higher than in the G1 group (p=0.003). In the determination of NSE concentration values according to the degree of liver involvement, in the group of patients with 10% liver involvement, the mean value of NSE concentration was 49.37 ng/ml, while in the group with 25% liver involvement, the value was 143.13 ng/ml (p < 0.001). In the analysis of NSE concentration assessment in patients with disease progression, the mean value was 129.65 ng/ml compared to the group with disease stabilization, where the mean NSE value was significantly lower and amounted to 52.61 ng/ml (p < 0.001). Conclusions: In our study, we observed that NSE concentration values were significantly higher among patients with NET midgut type tumor with histological grade G2 and in patients with 25% liver involvement and progression of the disease process.

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Keywords

neuron-specific enolase; neuroendocrine tumors; midgut; somatostatin analogs

About this article
Title

Determination of neuron-specific enolase in patients with midgut type tumor treated with somatostatin analogues

Journal

Endokrynologia Polska

Issue

Ahead of print

Article type

Original paper

Published online

2021-06-08

DOI

10.5603/EP.a2021.0060

Keywords

neuron-specific enolase
neuroendocrine tumors
midgut
somatostatin analogs

Authors

Paweł Gut
Agata Czarnywojtek
Nadia Sawicka - Gutaj
Kosma Woliński
Adam Maciejewski
Paweł Komarnicki
Marek Ruchała

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