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Original paper
Published online: 2021-02-24
Submitted: 2020-12-27
Accepted: 2021-01-27
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Triglyceride-Glucose Index Levels in Patients with Congenital Hypogonadotropic Hypogonadism and Relationship with Endothelial Dysfunction and Insulin Resistance

Ibrahim Demirci, Cem Haymana, Burcu Candemir, Coskun Meric, Bagdagul Yuksel, Mithat Eser, Onur Akın, Safak Akın, Nese Ersoz Gulcelik, Alper Sonmez
DOI: 10.5603/EP.a2021.0019
·
Pubmed: 33749808

open access

Ahead of print
Original Paper
Published online: 2021-02-24
Submitted: 2020-12-27
Accepted: 2021-01-27

Abstract

Introduction: The risk of cardiometabolic diseases is increased in patients with hypogonadism. The triglyceride-glucose (TyG) index is a novel surrogate marker of insulin resistance and is associated with cardiovascular diseases. We investigated the TyG index levels and the relationship with endothelial dysfunction and insulin resistance in patients with congenital hypogonadotropic hypogonadism (CHH).

Material and methods: A total of 98 patients with CHH (mean age 21.66 ± 1.99 years) and 98 healthy control subjects (mean age 21.69 ± 1.21 years) were enrolled. The demographic parameters, TyG index, asymmetric dimethylarginine (ADMA), high-sensitivity C-reactive protein (hs-CRP), and homeostatic model assessment of insulin resistance (HOMA-IR) levels were measured for all participants.

Results: The patients had higher waist circumference (p < 0.001), triglycerides (p = 0.001), insulin (p = 0.003), HOMA-IR (p = 0.002), ADMA (p < 0.001), and TyG index (p < 0.001) levels and lower HDL-C (p = 0.044) and total testosterone (p < 0.001) levels compared to healthy control subjects. TyG index levels significantly correlated with the ADMA (r = 0.31, p = 0.003) and HOMA-IR (r = 0.32, p < 0.001) levels. TyG index was also determinant of HOMA-IR levels (ß = 0.20, p = 0.018).

Conclusion: The results of the present study show that patients with CHH had increased TyG index levels. Also, the TyG index is independently associated with insulin resistance in patients with CHH. Long-term follow-up studies are warranted to find out the role of the TyG index in determining cardiometabolic risk in patients with hypogonadism.

 

Abstract

Introduction: The risk of cardiometabolic diseases is increased in patients with hypogonadism. The triglyceride-glucose (TyG) index is a novel surrogate marker of insulin resistance and is associated with cardiovascular diseases. We investigated the TyG index levels and the relationship with endothelial dysfunction and insulin resistance in patients with congenital hypogonadotropic hypogonadism (CHH).

Material and methods: A total of 98 patients with CHH (mean age 21.66 ± 1.99 years) and 98 healthy control subjects (mean age 21.69 ± 1.21 years) were enrolled. The demographic parameters, TyG index, asymmetric dimethylarginine (ADMA), high-sensitivity C-reactive protein (hs-CRP), and homeostatic model assessment of insulin resistance (HOMA-IR) levels were measured for all participants.

Results: The patients had higher waist circumference (p < 0.001), triglycerides (p = 0.001), insulin (p = 0.003), HOMA-IR (p = 0.002), ADMA (p < 0.001), and TyG index (p < 0.001) levels and lower HDL-C (p = 0.044) and total testosterone (p < 0.001) levels compared to healthy control subjects. TyG index levels significantly correlated with the ADMA (r = 0.31, p = 0.003) and HOMA-IR (r = 0.32, p < 0.001) levels. TyG index was also determinant of HOMA-IR levels (ß = 0.20, p = 0.018).

Conclusion: The results of the present study show that patients with CHH had increased TyG index levels. Also, the TyG index is independently associated with insulin resistance in patients with CHH. Long-term follow-up studies are warranted to find out the role of the TyG index in determining cardiometabolic risk in patients with hypogonadism.

 

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Keywords

triglyceride-glucose index; hypogonadism; ADMA; insulin resistance; congenital hypogonadotropic hypogonadism; cardiovascular risk

About this article
Title

Triglyceride-Glucose Index Levels in Patients with Congenital Hypogonadotropic Hypogonadism and Relationship with Endothelial Dysfunction and Insulin Resistance

Journal

Endokrynologia Polska

Issue

Ahead of print

Article type

Original paper

Published online

2021-02-24

DOI

10.5603/EP.a2021.0019

Pubmed

33749808

Keywords

triglyceride-glucose index
hypogonadism
ADMA
insulin resistance
congenital hypogonadotropic hypogonadism
cardiovascular risk

Authors

Ibrahim Demirci
Cem Haymana
Burcu Candemir
Coskun Meric
Bagdagul Yuksel
Mithat Eser
Onur Akın
Safak Akın
Nese Ersoz Gulcelik
Alper Sonmez

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