open access

Vol 72, No 1 (2021)
Review paper
Published online: 2021-01-11
Submitted: 2020-12-07
Accepted: 2020-12-20
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Cushing's syndrome in pregnancy: a review of reported cases

Georgios Kyriakos, Paraskevi Farmaki, Errika Voutyritsa, Alexandros Patsouras, Lourdes Victoria Quiles-Sánchez, Christos Damaskos, Athanasia Stelianidi, Adrián Pastor-Alcaraz, Patricia Palomero-Entrenas, Evangelos Diamantis
DOI: 10.5603/EP.a2020.0089
·
Pubmed: 33749819
·
Endokrynologia Polska 2021;72(1):64-72.

open access

Vol 72, No 1 (2021)
Review Article
Published online: 2021-01-11
Submitted: 2020-12-07
Accepted: 2020-12-20

Abstract

Cushing’s syndrome (CS) causes hypogonadotropic hypogonadism and anovulatory infertility due to hypercortisolism, and it is very rare in pregnancy. CS in pregnancy is associated with important maternal-foetal morbidity and mortality, such as preeclampsia and premature delivery.

A systematic search was conducted in the MEDLINE library to retrieve articles reporting cases of CS in pregnant women, during the period between 2010 and 2020.Thirty-five reported cases are presented focusing on the ability of diagnosis, treatment therapies, and foetal outcomes.

Diagnosis of CS during pregnancy can be challenging and is often delayed, adrenal adenoma being the predominant cause. Both medical treatment and surgery aiming at restoring the cortisol balance reduce maternal and foetal complications.

Abstract

Cushing’s syndrome (CS) causes hypogonadotropic hypogonadism and anovulatory infertility due to hypercortisolism, and it is very rare in pregnancy. CS in pregnancy is associated with important maternal-foetal morbidity and mortality, such as preeclampsia and premature delivery.

A systematic search was conducted in the MEDLINE library to retrieve articles reporting cases of CS in pregnant women, during the period between 2010 and 2020.Thirty-five reported cases are presented focusing on the ability of diagnosis, treatment therapies, and foetal outcomes.

Diagnosis of CS during pregnancy can be challenging and is often delayed, adrenal adenoma being the predominant cause. Both medical treatment and surgery aiming at restoring the cortisol balance reduce maternal and foetal complications.

Get Citation

Keywords

Cushing’s syndrome; pregnancy; hypercortisolism; adrenocortical adenoma; pituitary adenoma; review

About this article
Title

Cushing's syndrome in pregnancy: a review of reported cases

Journal

Endokrynologia Polska

Issue

Vol 72, No 1 (2021)

Article type

Review paper

Pages

64-72

Published online

2021-01-11

DOI

10.5603/EP.a2020.0089

Pubmed

33749819

Bibliographic record

Endokrynologia Polska 2021;72(1):64-72.

Keywords

Cushing’s syndrome
pregnancy
hypercortisolism
adrenocortical adenoma
pituitary adenoma
review

Authors

Georgios Kyriakos
Paraskevi Farmaki
Errika Voutyritsa
Alexandros Patsouras
Lourdes Victoria Quiles-Sánchez
Christos Damaskos
Athanasia Stelianidi
Adrián Pastor-Alcaraz
Patricia Palomero-Entrenas
Evangelos Diamantis

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