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Vol 72, No 1 (2021)
Review paper
Submitted: 2020-12-07
Accepted: 2020-12-20
Published online: 2021-01-11
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Cushing's syndrome in pregnancy: a review of reported cases

Georgios Kyriakos1, Paraskevi Farmaki2, Errika Voutyritsa3, Alexandros Patsouras4, Lourdes Victoria Quiles-Sánchez5, Christos Damaskos6, Athanasia Stelianidi2, Adrián Pastor-Alcaraz1, Patricia Palomero-Entrenas1, Evangelos Diamantis7
DOI: 10.5603/EP.a2020.0089
·
Pubmed: 33749819
·
Endokrynol Pol 2021;72(1):64-72.
Affiliations
  1. Sección de Endocrinología y Nutrición, Hospital General Universitario Santa Lucía, Cartagena, Spain, Cartagena, Spain
  2. First Department of Paediatrics, Agia Sofia Children’s Hospital, National and Kapodistrian University of Athens, Athens, Greece
  3. NS Christeas Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, Athens, Greece
  4. Second Department of Internal Medicine, Tzaneio General Hospital of Piraeus, Piraeus, Greece
  5. Centro de Salud Beniel, Murcia, Spain
  6. Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
  7. Department of Endocrinology and Diabetes Centre, G. Gennimatas General Hospital, Athens, Greece

open access

Vol 72, No 1 (2021)
Review Article
Submitted: 2020-12-07
Accepted: 2020-12-20
Published online: 2021-01-11

Abstract

Cushing’s syndrome (CS) causes hypogonadotropic hypogonadism and anovulatory infertility due to hypercortisolism, and it is very rare in pregnancy. CS in pregnancy is associated with important maternal-foetal morbidity and mortality, such as preeclampsia and premature delivery.

A systematic search was conducted in the MEDLINE library to retrieve articles reporting cases of CS in pregnant women, during the period between 2010 and 2020.Thirty-five reported cases are presented focusing on the ability of diagnosis, treatment therapies, and foetal outcomes.

Diagnosis of CS during pregnancy can be challenging and is often delayed, adrenal adenoma being the predominant cause. Both medical treatment and surgery aiming at restoring the cortisol balance reduce maternal and foetal complications.

Abstract

Cushing’s syndrome (CS) causes hypogonadotropic hypogonadism and anovulatory infertility due to hypercortisolism, and it is very rare in pregnancy. CS in pregnancy is associated with important maternal-foetal morbidity and mortality, such as preeclampsia and premature delivery.

A systematic search was conducted in the MEDLINE library to retrieve articles reporting cases of CS in pregnant women, during the period between 2010 and 2020.Thirty-five reported cases are presented focusing on the ability of diagnosis, treatment therapies, and foetal outcomes.

Diagnosis of CS during pregnancy can be challenging and is often delayed, adrenal adenoma being the predominant cause. Both medical treatment and surgery aiming at restoring the cortisol balance reduce maternal and foetal complications.

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Keywords

Cushing’s syndrome; pregnancy; hypercortisolism; adrenocortical adenoma; pituitary adenoma; review

About this article
Title

Cushing's syndrome in pregnancy: a review of reported cases

Journal

Endokrynologia Polska

Issue

Vol 72, No 1 (2021)

Article type

Review paper

Pages

64-72

Published online

2021-01-11

Page views

1361

Article views/downloads

1177

DOI

10.5603/EP.a2020.0089

Pubmed

33749819

Bibliographic record

Endokrynol Pol 2021;72(1):64-72.

Keywords

Cushing’s syndrome
pregnancy
hypercortisolism
adrenocortical adenoma
pituitary adenoma
review

Authors

Georgios Kyriakos
Paraskevi Farmaki
Errika Voutyritsa
Alexandros Patsouras
Lourdes Victoria Quiles-Sánchez
Christos Damaskos
Athanasia Stelianidi
Adrián Pastor-Alcaraz
Patricia Palomero-Entrenas
Evangelos Diamantis

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