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Original paper
Published online: 2021-02-26
Submitted: 2020-11-30
Accepted: 2021-01-10
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Low dietary calcium intake does not modify fracture risk but increases falls frequency: the results of GO Study

Wojciech Pluskiewicz, Piotr Adamczyk, Bogna Drozdzowska
DOI: 10.5603/EP.a2021.0021
·
Pubmed: 33749809

open access

Ahead of print
Original Paper
Published online: 2021-02-26
Submitted: 2020-11-30
Accepted: 2021-01-10

Abstract

The aim of the study was to verify the thesis that dietary calcium intake influences the risk of osteoporotic fractures established by online available calculators. Material. The study was performed in 521 postmenopausal women aged over 55 years recruited in one osteoporotic outpatient clinic. Mean age was 67.7±8.6 years. Methods. Fracture risk was established using FRAX (major and hip fractures, 10 years), Garvan calculator (any and hip fractures, 5 and 10 years) and Polish algorithm available at www.fracture-risk.pl (any fractures, 5 years). Bone densitometry at femoral neck was performed using a device Prodigy (Lunar, GE, USA) to calculate fracture risk by each of those calculators. Calcium intake was established based on dietary questionnaire. Results. Mean values of fracture risk for all three calculators and T-score value for DXA measurement at femoral neck did not correlate with calcium intake. A tendency to insignificantly lower calcium intake was observed in subgroup with high hip fracture risk by FRAX (≥3%) versus low hip FRAX (<3%): 744±328 mg/day vs. 765±299 mg/day. The same analysis for FRAX major fracture risk revealed similar tendency: 700±299 mg/day and 760±311 mg/day in high (≥20%) and low (<20%) fracture risk groups, respectively. Calcium intake did not influence at all the results obtained in two others calculators. Calcium intake did not differ between subjects with prior falls and those ones without falls. However, if the number of falls was taken into account, the women who reported three and more falls had significantly lower calcium intake (621±275 mg/day) than subjects with no falls (767±304 mg/day; p<0.05) or with one fall (766±317 mg/day; p<0.05). Concluding, calcium intake does not correlate with fracture risk established by calculators available on-line but low calcium intake may increase the risk of falls.

Abstract

The aim of the study was to verify the thesis that dietary calcium intake influences the risk of osteoporotic fractures established by online available calculators. Material. The study was performed in 521 postmenopausal women aged over 55 years recruited in one osteoporotic outpatient clinic. Mean age was 67.7±8.6 years. Methods. Fracture risk was established using FRAX (major and hip fractures, 10 years), Garvan calculator (any and hip fractures, 5 and 10 years) and Polish algorithm available at www.fracture-risk.pl (any fractures, 5 years). Bone densitometry at femoral neck was performed using a device Prodigy (Lunar, GE, USA) to calculate fracture risk by each of those calculators. Calcium intake was established based on dietary questionnaire. Results. Mean values of fracture risk for all three calculators and T-score value for DXA measurement at femoral neck did not correlate with calcium intake. A tendency to insignificantly lower calcium intake was observed in subgroup with high hip fracture risk by FRAX (≥3%) versus low hip FRAX (<3%): 744±328 mg/day vs. 765±299 mg/day. The same analysis for FRAX major fracture risk revealed similar tendency: 700±299 mg/day and 760±311 mg/day in high (≥20%) and low (<20%) fracture risk groups, respectively. Calcium intake did not influence at all the results obtained in two others calculators. Calcium intake did not differ between subjects with prior falls and those ones without falls. However, if the number of falls was taken into account, the women who reported three and more falls had significantly lower calcium intake (621±275 mg/day) than subjects with no falls (767±304 mg/day; p<0.05) or with one fall (766±317 mg/day; p<0.05). Concluding, calcium intake does not correlate with fracture risk established by calculators available on-line but low calcium intake may increase the risk of falls.

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Keywords

calcium intake; falls; fracture risk

About this article
Title

Low dietary calcium intake does not modify fracture risk but increases falls frequency: the results of GO Study

Journal

Endokrynologia Polska

Issue

Ahead of print

Article type

Original paper

Published online

2021-02-26

DOI

10.5603/EP.a2021.0021

Pubmed

33749809

Keywords

calcium intake
falls
fracture risk

Authors

Wojciech Pluskiewicz
Piotr Adamczyk
Bogna Drozdzowska

References (17)
  1. Zhu K, Prince RL. Calcium and bone. Clin Biochem. 2012; 45(12): 936–942.
  2. Tai V, Leung W, Grey A, et al. Calcium intake and bone mineral density: systematic review and meta-analysis. BMJ. 2015; 351: h4183.
  3. Khan B, Nowson CA, Daly RM, et al. Higher Dietary Calcium Intakes Are Associated With Reduced Risks of Fractures, Cardiovascular Events, and Mortality: A Prospective Cohort Study of Older Men and Women. J Bone Miner Res. 2015; 30(10): 1758–1766.
  4. Vannucci L, Masi L, Gronchi G, et al. Calcium intake, bone mineral density, and fragility fractures: evidence from an Italian outpatient population. Arch Osteoporos. 2017; 12(1): 40.
  5. Warensjö E, Byberg L, Melhus H, et al. Dietary calcium intake and risk of fracture and osteoporosis: prospective longitudinal cohort study. BMJ. 2011; 342: d1473.
  6. Zhao JG, Zeng XT, Wang J, et al. Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis. JAMA. 2017; 318(24): 2466–2482.
  7. Harvey NC, Biver E, Kaufman JM, et al. The role of calcium supplementation in healthy musculoskeletal ageing : An expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF). Osteoporos Int. 2016; 28(2): 447–462.
  8. Pham TT, Nguyen DN, Dutkiewicz E, et al. A profiling analysis of contributions of cigarette smoking, dietary calcium intakes, and physical activity to fragility fracture in the elderly. Sci Rep. 2018; 8(1): 10374.
  9. van den Berg P, van Haard PMM, van den Bergh JPW, et al. First quantification of calcium intake from calcium-dense dairy products in Dutch fracture patients (the Delft cohort study). Nutrients. 2014; 6(6): 2404–2418.
  10. Włodarek D, Głąbska D, Kołota A, et al. Calcium intake and osteoporosis: the influence of calcium intake from dairy products on hip bone mineral density and fracture incidence - a population-based study in women over 55 years of age. Public Health Nutr. 2014; 17(2): 383–389.
  11. Jeong SH, Kim JS. Impaired Calcium Metabolism in Benign Paroxysmal Positional Vertigo: A Topical Review. J Neurol Phys Ther. 2019; 43(Suppl 2): S37–S41.
  12. Huang TC, Cecchin FC, Mahoney P, et al. Corrected QT interval (QTc) prolongation and syncope associated with pseudohypoparathyroidism and hypocalcemia. J Pediatr. 2000; 136(3): 404–407.
  13. Kanis JA, Cooper C, Rizzoli R, et al. Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF). Executive summary of European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Aging Clin Exp Res. 2019; 31(1): 15–17.
  14. Nguyen ND, Frost SA, Center JR, et al. Development of a nomogram for individualizing hip fracture risk in men and women. Osteoporos Int. 2007; 18(8): 1109–1117.
  15. Nguyen ND, Frost SA, Center JR, et al. Development of prognostic nomograms for individualizing 5-year and 10-year fracture risks. Osteoporos Int. 2008; 19(10): 1431–1444.
  16. Adamczyk P, Werner A, Bach M, et al. Risk Factors for Fractures Identified in the Algorithm Developed in 5-Year Follow-Up of Postmenopausal Women From RAC-OST-POL Study. J Clin Densitom. 2018; 21(2): 213–219.
  17. Worksheet to Find Out How Much Calcium You Need Each Day. Department of Health, New York State. https://www.health.ny.gov/publications/1981/index.htm (28.12.2020.).

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