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Bone status in adolescents and young adults with type 1 diabetes: a 10-year longitudinal study
, 2, 3, 4, 5
Affiliations- Department of Pediatrics, Institute of Medical Sciences, University of Opole, Opole, Poland
- Department of Children’s Diabetology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
- Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland, Zabrze, Poland
- Department of Data Sciences and Engineering, Silesian University of Technology, Katowice, Poland
- Department of Metabolic Bones Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland
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Abstract
Introduction: This study presents a 10-year longitudinal assessment of bone status in adolescents and young adults with type 1 diabetes (T1D).
Material and methods: Thirty-two patients (12 female, aged 20.5 ± 3.93 years, T1D duration 13.9 ± 1.97 years) were studied using quantitative ultrasound (QUS) and dual-energy X-ray absorptiometry (DXA). Standard deviation scores (SDS) for these results were calculated. The following clinical parameters were analysed: sex, age, T1D duration, anthropometric parameters, daily insulin requirement (DIR), mean glycated haemoglobin (HbA1c) in the year preceding the examination, medication other than insulin, history of bone fractures, and comorbidities.
Results: The current and past (measured 10 years earlier) QUS results did not differ and showed a significant correlation (r = 0.55, p = 0.001). We found no relation of QUS results and anthropometric parameters or gender. DXA parameters did not correlate with the present QUS measurement. DXA and QUS results were independent of HbA1c, co-morbidities, or intake of additional medicaments.
Conclusions: Bone status parameters of the examined patients with currently suboptimal glycaemic control were found to be lowered in comparison to a normative reference population, both at baseline and follow-up, although no further deterioration was observed during the 10-year follow-up period.
Abstract
Introduction: This study presents a 10-year longitudinal assessment of bone status in adolescents and young adults with type 1 diabetes (T1D).
Material and methods: Thirty-two patients (12 female, aged 20.5 ± 3.93 years, T1D duration 13.9 ± 1.97 years) were studied using quantitative ultrasound (QUS) and dual-energy X-ray absorptiometry (DXA). Standard deviation scores (SDS) for these results were calculated. The following clinical parameters were analysed: sex, age, T1D duration, anthropometric parameters, daily insulin requirement (DIR), mean glycated haemoglobin (HbA1c) in the year preceding the examination, medication other than insulin, history of bone fractures, and comorbidities.
Results: The current and past (measured 10 years earlier) QUS results did not differ and showed a significant correlation (r = 0.55, p = 0.001). We found no relation of QUS results and anthropometric parameters or gender. DXA parameters did not correlate with the present QUS measurement. DXA and QUS results were independent of HbA1c, co-morbidities, or intake of additional medicaments.
Conclusions: Bone status parameters of the examined patients with currently suboptimal glycaemic control were found to be lowered in comparison to a normative reference population, both at baseline and follow-up, although no further deterioration was observed during the 10-year follow-up period.
Keywords
type 1 diabetes; glycaemic control; bone status; quantitative ultrasound; dual X-ray absorptiometry
About this articleTitle
Bone status in adolescents and young adults with type 1 diabetes: a 10-year longitudinal study
Journal
Issue
Article type
Original paper
Pages
532-538
Published online
2020-12-01
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957
Article views/downloads
716
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2020;71(6):532-538.
Keywords
type 1 diabetes
glycaemic control
bone status
quantitative ultrasound
dual X-ray absorptiometry
Authors
Agata Chobot
Oliwia Janota
Katarzyna Bąk-Drabik
Joanna Polanska
Wojciech Pluskiewicz
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