Vol 71, No 2 (2020)
Clinical vignette
Published online: 2020-01-07

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Insulin autoimmune syndrome — time to remember

Nalan Okuroglu1, Meltem Sertbas1, Cafer Akkoz1, Yasar Sertbas1, Seda Sancak2, Ali Ozdemir1
Pubmed: 31909453
Endokrynol Pol 2020;71(2):204-205.


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  1. Ismail AA. The insulin autoimmune syndrome (IAS) as a cause of hypoglycaemia: an update on the pathophysiology, biochemical investigations and diagnosis. Clin Chem Lab Med. 2016; 54(11): 1715–1724.
  2. Packer L, Cadenas E. Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. J Clin Biochem Nutr. 2011; 48(1): 26–32.
  3. Uchigata Y, Hirata Y, Iwamoto Y. Insulin autoimmune syndrome (Hirata disease): epidemiology in Asia, including Japan. Diabetol Int. 2010; 1(1): 21–25.
  4. Izzo V, Greco C, Corradini D, et al. Insulin autoimmune syndrome in an Argentine woman taking α-lipoic acid: A case report and review of the literature. SAGE Open Med Case Rep. 2018; 6: 2050313X18819601.
  5. Gullo D, Evans JL, Sortino G, et al. Insulin autoimmune syndrome (Hirata Disease) in European Caucasians taking α-lipoic acid. Clin Endocrinol (Oxf). 2014; 81(2): 204–209.