open access

Vol 70, No 6 (2019)
Review paper
Published online: 2019-12-20
Submitted: 2019-07-22
Accepted: 2019-07-29
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Endocrine diseases as causes of secondary hyperlipidemia

Łukasz Bułdak, Bogdan Marek, Dariusz Kajdaniuk, Agata Urbanek, Szymon Janyga, Aleksandra Bołdys, Marcin Basiak, Mateusz Maligłówka, Bogusław Okopień
DOI: 10.5603/EP.a2019.0041
·
Pubmed: 31891414
·
Endokrynologia Polska 2019;70(6):511-519.

open access

Vol 70, No 6 (2019)
REVIEWS — Postgraduate Education
Published online: 2019-12-20
Submitted: 2019-07-22
Accepted: 2019-07-29

Abstract

Cardiovascular diseases are among the leading causes of increased morbidity and mortality in developed and developing countries. One of the most important risk factors responsible for atherosclerosis and subsequent cardiovascular diseases is hyperlipidaemia. Currently, hyperlipidaemias are divided into several clinical entities. The greatest risk is associated with hypercholesterolaemia. As a result, modern guidelines for the treatment and prevention of atherosclerosis focus predominantly on the reduction of LDL-cholesterol. Hypertriglyceridaemia and atherogenic dyslipidaemia, which are responsible for a less significant increase in the cardiovascular risk, are nowadays secondary targets of the treatment.

During the work-up for hyperlipidaemia one of the essential actions is the exclusion of secondary causes of the lipid abnormalities. Those include, among others, endocrine diseases, diabetes, drugs, nephrotic syndrome, and pregnancy. Data regarding the impact of endocrine disease and diabetes on the lipid profile are scattered. In this review, the authors aimed to perform a thorough analysis of the available publications regarding the topic and the preparation of a comprehensive review dealing with the incidence, clinical features, and the therapy of hyperlipidaemias in patients with endocrine disease. 

Abstract

Cardiovascular diseases are among the leading causes of increased morbidity and mortality in developed and developing countries. One of the most important risk factors responsible for atherosclerosis and subsequent cardiovascular diseases is hyperlipidaemia. Currently, hyperlipidaemias are divided into several clinical entities. The greatest risk is associated with hypercholesterolaemia. As a result, modern guidelines for the treatment and prevention of atherosclerosis focus predominantly on the reduction of LDL-cholesterol. Hypertriglyceridaemia and atherogenic dyslipidaemia, which are responsible for a less significant increase in the cardiovascular risk, are nowadays secondary targets of the treatment.

During the work-up for hyperlipidaemia one of the essential actions is the exclusion of secondary causes of the lipid abnormalities. Those include, among others, endocrine diseases, diabetes, drugs, nephrotic syndrome, and pregnancy. Data regarding the impact of endocrine disease and diabetes on the lipid profile are scattered. In this review, the authors aimed to perform a thorough analysis of the available publications regarding the topic and the preparation of a comprehensive review dealing with the incidence, clinical features, and the therapy of hyperlipidaemias in patients with endocrine disease. 

Get Citation

Keywords

hypercholesterolaemia; hypertriglyceridaemia; hyperlipidaemia; endocrine disease; diabetes

About this article
Title

Endocrine diseases as causes of secondary hyperlipidemia

Journal

Endokrynologia Polska

Issue

Vol 70, No 6 (2019)

Article type

Review paper

Pages

511-519

Published online

2019-12-20

DOI

10.5603/EP.a2019.0041

Pubmed

31891414

Bibliographic record

Endokrynologia Polska 2019;70(6):511-519.

Keywords

hypercholesterolaemia
hypertriglyceridaemia
hyperlipidaemia
endocrine disease
diabetes

Authors

Łukasz Bułdak
Bogdan Marek
Dariusz Kajdaniuk
Agata Urbanek
Szymon Janyga
Aleksandra Bołdys
Marcin Basiak
Mateusz Maligłówka
Bogusław Okopień

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