Vol 70, No 1 (2019)
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Published online: 2018-10-23

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Treatment of severe primary IGF-1 deficiency using rhIGF-1 preparation — first three years of Polish experience

Elżbieta Petriczko1, Tomasz Jackowski1, Anita Horodnicka-Józwa1, Beata Wikiera2, Anna Noczyńska2, Maria Korpal-Szczyrska3, Dorota Birkholz-Walerzak3, Ewa Małecka-Tendera4, Barbara Kalina-Fraska4, Maria Kalina5, Ewa Barg6, Iwona Beń-Skowronek7, Leszek Szewczyk7, Maciej Hilczer89, Joanna Smyczyńska8, Renata Stawerska8, Andrzej Lewiński108, Katarzyna Ziora11, Artur Bossowski12, Edyta Pietrewicz12, Beata Pyrżak13, Andrzej Kędzia14, Mieczysław Szalecki1516, Agnieszka Kilian1, Mieczysław Walczak1
Pubmed: 30351442
Endokrynol Pol 2019;70(1):20-27.


Introduction: The objective of this study was to analyse the effects of the first three years of treatment with recombinant human insulinlike growth factor 1 (rhIGF-1) in patients from the Polish population.

Material and methods: Twenty-seven children (22 boys and five girls) aged 2.8 to 16.0 years old were qualified for treatment with rhIGF-1 (mecasermin) in different treatment centres, according to Polish criteria: body height below –3.0 SD and IGF-1 concentration below percentile 2.5 with normal growth hormone (GH) levels. Mecasermin initial dose was 40 μg/kg bw twice a day and was subsequently increased to an average of 100 μg/kg bw twice a day. Body height, height velocity, weight, body mass index (BMI), and adverse events were measured.

Results: Mecasermin treatment resulted in a statistically significant increase in body height (1.45 ± 1.06 SD; p < 0.01) and height velocity in comparison with pre-treatment values. The biggest change in height velocity happened during the first year and diminished during subsequent years. Body weight and BMI also increased significantly after treatment (1.16 ± 0.76 SD and 0.86 ± 0.75 SD, respectively; p < 0.01). Eight patients reported adverse events. These were mild and temporary and did not require treatment modification except in two patients.

Conclusions: Treatment with rhIGF-1 was effective and safe in Polish patients with primary IGF-1 deficiency. It had a clear beneficial effect on the height of the patients and significantly accelerated the height velocity, particularly in the first year of treatment.

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