Vol 70, No 2 (2019)
Review paper
Published online: 2019-04-30

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The new adipokine zinc-α2-glycoprotein (ZAG) as a link between adipose tissue and kidney? [Czy nowa adipocytokina cynkowa α2-glikoproteina (ZAG) stanowi ogniwo między tkanką tłuszczową a nerkami?]

Łukasz A. Woźny1, Małgorzata Morawiecka-Pietrzak23, Majka Jaszczura2, Katarzyna Ziora2, Władysław Grzeszczak3
Pubmed: 31070771
Endokrynol Pol 2019;70(2):171-189.


Adipose tissue is currently considered not only as an energy store but also as an organ of internal secretion. Numerous adipocytokines regulating a number of human body processes are important in many disease processes, including chronic kidney disease (CKD). Nowadays, the role of zinc a2-glycoprotein (ZAG) is being sought as a potential link between these two organs. ZAG, through its lipolytic effect, contributes to progressive malnutrition in patients undergoing dialysis, and this significantly increases their mortality. It seems that ZAG may be a new potential biomarker of kidney damage, and the specific pharmacotherapy will significantly reduce the progressive process of cachexia.

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