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Vol 69, No 5 (2018)
Original paper
Submitted: 2018-06-10
Accepted: 2018-06-21
Published online: 2018-08-14
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Plasma adiponectin array in women with Alzheimer’s disease

Agnieszka Baranowska-Bik1, Małgorzata Kalisz2, Lidia Martyńska2, Ewa Wolińska-Witort2, Maria Styczyńska3, Małgorzata Chodakowska-Żebrowska4, Maria Barcikowska3, Bogusława Baranowska5, Wojciech Bik2
DOI: 10.5603/EP.a2018.0055
·
Pubmed: 30117532
·
Endokrynol Pol 2018;69(5):550-559.
Affiliations
  1. Department of Endocrinology, Centre of Postgraduate Medical Education, Bielański Hospital, ul. Cegłowska 80, 01-809 Warsaw, Poland
  2. Department of Neuroendocrinology, Centre of Postgraduate Medical Education, Marymoncka 99/103, 01-813 Warsaw, Poland
  3. Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawińskiego 5, 02-106 Warsaw, Poland
  4. Department of Neurology, Central Clinical Hospital of the Ministry of Interior, Wołoska 137, 02-507 Warsaw, Poland
  5. Department of Neurology, Second Faculty of Medicine, Medical University of Warsaw, Bielański Hospital, Cegłowska 80, 01-809 Warsaw, Poland

open access

Vol 69, No 5 (2018)
Original Paper
Submitted: 2018-06-10
Accepted: 2018-06-21
Published online: 2018-08-14

Abstract

ABSTRACT Introduction Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative disease. Typical features of AD include memory loss, social dysfunction and physical impairment. Although the pathological findings in the central nervous system are well established, the etiological factors are poorly known. Recent studies suggested the role of metabolic disturbances in the development of AD neurodegeneration. Adiponectin, an anti-inflammatory and metabolism regulating factor, was linked to AD. Aim The aim was to examine whether adiponectin fractions combined with insulin/insulin resistance-associated metabolic parameters correlate with AD progression. Material and methods The study comprised 98 women: 27 with moderate to severe AD, 31 with AD at early stage and 40 healthy controls, matched for age and BMI. To evaluate memory impairment, the MMSE was performed. Plasma total adiponectin and its high-, medium- and low molecular weights were measured with ELISA. Anthropometric, clinical and metabolic parameters were assessed. Correlations between adiponectin array and measured parameters were evaluated. Results In comparison to the controls, enhanced levels of total and medium molecular weight adiponectin characterized AD individuals. In AD, we found correlations between adiponectin array, and anthropometric and biochemical parameters. After adjustment to BMI, a significant increase of the total adiponectin and high- and medium molecular weight fractions was observed. A negative correlation between low molecular weight adiponectin and MMSE was found. Conclusions Our results indicate a possible link between adiponectin variations and AD. We hypothesize that changes in adiponectin profile observed in AD result from compensatory mechanism against neuropathological processes, as well as from adiponectin homeostasis impairment.

Abstract

ABSTRACT Introduction Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative disease. Typical features of AD include memory loss, social dysfunction and physical impairment. Although the pathological findings in the central nervous system are well established, the etiological factors are poorly known. Recent studies suggested the role of metabolic disturbances in the development of AD neurodegeneration. Adiponectin, an anti-inflammatory and metabolism regulating factor, was linked to AD. Aim The aim was to examine whether adiponectin fractions combined with insulin/insulin resistance-associated metabolic parameters correlate with AD progression. Material and methods The study comprised 98 women: 27 with moderate to severe AD, 31 with AD at early stage and 40 healthy controls, matched for age and BMI. To evaluate memory impairment, the MMSE was performed. Plasma total adiponectin and its high-, medium- and low molecular weights were measured with ELISA. Anthropometric, clinical and metabolic parameters were assessed. Correlations between adiponectin array and measured parameters were evaluated. Results In comparison to the controls, enhanced levels of total and medium molecular weight adiponectin characterized AD individuals. In AD, we found correlations between adiponectin array, and anthropometric and biochemical parameters. After adjustment to BMI, a significant increase of the total adiponectin and high- and medium molecular weight fractions was observed. A negative correlation between low molecular weight adiponectin and MMSE was found. Conclusions Our results indicate a possible link between adiponectin variations and AD. We hypothesize that changes in adiponectin profile observed in AD result from compensatory mechanism against neuropathological processes, as well as from adiponectin homeostasis impairment.

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Keywords

adiponectin; adiponectin fractions; Alzheimer’s disease

About this article
Title

Plasma adiponectin array in women with Alzheimer’s disease

Journal

Endokrynologia Polska

Issue

Vol 69, No 5 (2018)

Article type

Original paper

Pages

550-559

Published online

2018-08-14

Page views

2413

Article views/downloads

956

DOI

10.5603/EP.a2018.0055

Pubmed

30117532

Bibliographic record

Endokrynol Pol 2018;69(5):550-559.

Keywords

adiponectin
adiponectin fractions
Alzheimer’s disease

Authors

Agnieszka Baranowska-Bik
Małgorzata Kalisz
Lidia Martyńska
Ewa Wolińska-Witort
Maria Styczyńska
Małgorzata Chodakowska-Żebrowska
Maria Barcikowska
Bogusława Baranowska
Wojciech Bik

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