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Vol 69, No 3 (2018)
Original paper
Submitted: 2017-10-31
Accepted: 2018-01-08
Published online: 2018-03-02
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Red cell distribution width — a new marker for exacerbation of heart failure in patients with hypothyroidism following radioiodine therapy

Agata Czarnywojtek12, Nadia Sawicka-Gutaj1, Izabela Miechowicz3, Magdalena Borowska2, Kosma Woliński1, Maria Teresa Płazińska4, Ariadna Zybek-Kocik1, Ewa Straburzyńska-Migaj5, Małgorzata Zgorzalewicz-Stachowiak6, Aleksandra Hernik1, Ewelina Szczepanek-Parulska1, Marek Ruchała1
DOI: 10.5603/EP.a2018.0018
·
Pubmed: 29504626
·
Endokrynol Pol 2018;69(3):235-240.
Affiliations
  1. Department of Endocrinology, Metabolism, and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland
  2. Department of Pharmacology, University of Medical Sciences, Poznan
  3. Department of Computer Science and Statistics, University of Medical Sciences, Poznan
  4. Nuclear Medicine Department, Medical University of Warsaw
  5. Department of Cardiology, Poznan, University of Medical Sciences, Poznan
  6. Laboratory of Medical Electrodiagnostics, Department of Health Prophylaxis, University of Medical Sciences in Poznan, Poland

open access

Vol 69, No 3 (2018)
Original Paper
Submitted: 2017-10-31
Accepted: 2018-01-08
Published online: 2018-03-02

Abstract

Introduction: Cardiovascular diseases constitute a major cause of health problems and death in developed countries across the world. The increased value of the index of distribution of red blood cells volume (RDW) may be a prognostic marker in patients diagnosed with chronic heart failure (CHF). Hypothyroid patients present higher RDW values if compared to healthy controls. Taking into consideration that RDW might be both affected by thyroid status and CHF, we decided to determine the effect of concomitant hypothyroidism following radioiodine therapy (RIT) and CHF on hematological parameters. Materials and methods: Patients with toxic nodular goiter and heart failure with concomitant anemia were included. Patients underwent treatment with radioiodine before the planned heart transplant or pacemaker implantation (combined ICD/CRT-D). After RIT patients were divided into the three subgroups: with overt hypothyroidism (TSH ≥ 10µIU/mL, Group I), subclinically hypothyroid patients (TSH 4.3-9.0 µIU/mL, Group II) and with high-normal level of TSH (2.6-4.2 µIU/mL, Group III). Results: Significant correlation between TSH and RDW was observed (r=0.46; P < 0.0001) after RIT, whereas no correlation between serum TSH levels and TIBC and Fe was observed. In Group I significant correlation between TSH and RDW (r= 0.48; P = 0.002) after RIT was observed, whereas in two other subgroups there were no significant correlation. Conclusions: Subclinical hypothyroidism or high-normal levels of TSH did not affect RDW in a significant manner in the studied population. Our results demonstrates that overt hypothyroidism may contribute to deterioration of CHF reflected in changes of RDW value.

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Abstract

Introduction: Cardiovascular diseases constitute a major cause of health problems and death in developed countries across the world. The increased value of the index of distribution of red blood cells volume (RDW) may be a prognostic marker in patients diagnosed with chronic heart failure (CHF). Hypothyroid patients present higher RDW values if compared to healthy controls. Taking into consideration that RDW might be both affected by thyroid status and CHF, we decided to determine the effect of concomitant hypothyroidism following radioiodine therapy (RIT) and CHF on hematological parameters. Materials and methods: Patients with toxic nodular goiter and heart failure with concomitant anemia were included. Patients underwent treatment with radioiodine before the planned heart transplant or pacemaker implantation (combined ICD/CRT-D). After RIT patients were divided into the three subgroups: with overt hypothyroidism (TSH ≥ 10µIU/mL, Group I), subclinically hypothyroid patients (TSH 4.3-9.0 µIU/mL, Group II) and with high-normal level of TSH (2.6-4.2 µIU/mL, Group III). Results: Significant correlation between TSH and RDW was observed (r=0.46; P < 0.0001) after RIT, whereas no correlation between serum TSH levels and TIBC and Fe was observed. In Group I significant correlation between TSH and RDW (r= 0.48; P = 0.002) after RIT was observed, whereas in two other subgroups there were no significant correlation. Conclusions: Subclinical hypothyroidism or high-normal levels of TSH did not affect RDW in a significant manner in the studied population. Our results demonstrates that overt hypothyroidism may contribute to deterioration of CHF reflected in changes of RDW value.

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Keywords

RDW, hypothyroidism, heart failure, radioiodine therapy

About this article
Title

Red cell distribution width — a new marker for exacerbation of heart failure in patients with hypothyroidism following radioiodine therapy

Journal

Endokrynologia Polska

Issue

Vol 69, No 3 (2018)

Article type

Original paper

Pages

235-240

Published online

2018-03-02

Page views

1656

Article views/downloads

1198

DOI

10.5603/EP.a2018.0018

Pubmed

29504626

Bibliographic record

Endokrynol Pol 2018;69(3):235-240.

Keywords

RDW
hypothyroidism
heart failure
radioiodine therapy

Authors

Agata Czarnywojtek
Nadia Sawicka-Gutaj
Izabela Miechowicz
Magdalena Borowska
Kosma Woliński
Maria Teresa Płazińska
Ariadna Zybek-Kocik
Ewa Straburzyńska-Migaj
Małgorzata Zgorzalewicz-Stachowiak
Aleksandra Hernik
Ewelina Szczepanek-Parulska
Marek Ruchała

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