Vol 69, No 2 (2018)
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Published online: 2018-01-18

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The effect of vitamin D supplementation on sexual functioning and depressive symptoms in young women with low vitamin D status

Robert Krysiak, Anna Szwajkosz, Bogdan Marek, Bogusław Okopień
Pubmed: 29442353
Endokrynol Pol 2018;69(2):168-174.

Abstract

Background: Hypovitaminosis D is associated with abnormal female sexual functioning. The aim of our study was to assess whether vitamin D supplementation affects sexual functioning and depressive symptoms in young women with low vitamin D status. Methods: The study included 47 women with vitamin D deficiency or insufficiency. All women with vitamin D deficiency were treated with oral vitamin D, while women with vitamin D insufficiency were either treated with vitamin D or left untreated. At the beginning of the study and six months later, all patients completed questionnaires evaluating female sexual function (FSFI) and depressive symptoms (BDI-II). Results: The total FSFI score and scores in three domains (sexual desire, orgasm and satisfaction) were lower while the overall BDI-II score was higher in women with vitamin D deficiency than in women with vitamin D insufficiency. Vitamin D improved sexual desire in women with both vitamin D deficiency and vitamin D insufficiency, increased the total FSFI score and scores for orgasm and sexual satisfaction, as well as decreased the total BDI-II score in women with vitamin D deficiency. Conclusions: The obtained results indicate that vitamin D supplementation improves female sexual functioning and mood in women with low vitamin D status.

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References

  1. Ingraham BA, Bragdon B, Nohe A. Molecular basis of the potential of vitamin D to prevent cancer. Curr Med Res Opin. 2008; 24(1): 139–149.
  2. Teegarden D, Donkin SS. Vitamin D: emerging new roles in insulin sensitivity. Nutr Res Rev. 2009; 22(1): 82–92.
  3. Guillot X, Semerano L, Saidenberg-Kermanac'h N, et al. Vitamin D and inflammation. Joint Bone Spine. 2010; 77(6): 552–557.
  4. Haussler MR. Vitamin D receptors: nature and function. Annu Rev Nutr. 1986; 6: 527–562.
  5. Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357(3): 266–281.
  6. Pilz S, Grübler M, Gaksch M, et al. Vitamin D and mortality. Anticancer Res. 2016; 36(3): 1379–1387.
  7. Wranicz J, Szostak-Węgierek D. Health outcomes of vitamin D. Part II. Role in prevention of diseases. Rocz Panstw Zakl Hig. 2014; 65(4): 273–279.
  8. Pilz S, Verheyen N, Grübler MR, et al. Vitamin D and cardiovascular disease prevention. Nat Rev Cardiol. 2016; 13(7): 404–417.
  9. Zittermann A, Prokop S. The role of vitamin D for cardiovascular disease and overall mortality. Adv Exp Med Biol. 2014; 810: 106–119.
  10. Cutolo M, Pizzorni C, Sulli A. Vitamin D endocrine system involvement in autoimmune rheumatic diseases. Autoimmun Rev. 2011; 11(2): 84–87.
  11. Colonese F, Laganà AS, Colonese E, et al. The pleiotropic effects of vitamin D in gynaecological and obstetric diseases: an overview on a hot topic. Biomed Res Int. 2015; 2015: 986281.
  12. Caretta N, de Kreutzenberg SV, Valente U, et al. Hypovitaminosis D is associated with erectile dysfunction in type 2 diabetes. Endocrine. 2016; 53(3): 831–838.
  13. Barassi A, Pezzilli R, Colpi GM, et al. Vitamin D and erectile dysfunction. J Sex Med. 2014; 11(11): 2792–2800.
  14. Canguven O, Talib RA, El Ansari W, et al. Vitamin D treatment improves levels of sexual hormones, metabolic parameters and erectile function in middle-aged vitamin D deficient men. Aging Male. 2017; 20(1): 9–16.
  15. Krysiak R, Gilowska M, Okopień B. Sexual function and depressive symptoms in young women with low vitamin D status: a pilot study. Eur J Obstet Gynecol Reprod Biol. 2016; 204: 108–112.
  16. Rosen R, Brown C, Heiman J, et al. The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther. 2000; 26(2): 191–208.
  17. Wiegel M, Meston C, Rosen R. The female sexual function index (FSFI): cross-validation and development of clinical cutoff scores. J Sex Marital Ther. 2005; 31(1): 1–20.
  18. Beck AT, Steer RA, Brown GK. BDI-II: Beck Depression Inventory Manual. 2nd ed. San Antonio, Psychological Corporation 1996.
  19. American Psychiatric Association. Diagnostic and statistical manual of mental disorders - DSM-IV-TR. 4th ed. Washington, American Psychiatric Publishing 1994.
  20. Molinari C, Uberti F, Grossini E, et al. 1α,25-dihydroxycholecalciferol induces nitric oxide production in cultured endothelial cells. Cell Physiol Biochem. 2011; 27(6): 661–668.
  21. Andrukhova O, Slavic S, Zeitz U, et al. Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice. Mol Endocrinol. 2014; 28(1): 53–64.
  22. Martínez-Miguel P, Valdivielso JM, Medrano-Andrés D, et al. The active form of vitamin D, calcitriol, induces a complex dual upregulation of endothelin and nitric oxide in cultured endothelial cells. Am J Physiol Endocrinol Metab. 2014; 307(12): E1085–E1096.
  23. Lugg ST, Howells PA, Thickett DR. Optimal Vitamin D Supplementation Levels for Cardiovascular Disease Protection. Dis Markers. 2015; 2015: 864370.
  24. Mozos I, Marginean O. Links between Vitamin D Deficiency and Cardiovascular Diseases. Biomed Res Int. 2015; 2015: 109275.
  25. Chang EMi, Kim YS, Won HJ, et al. Association between sex steroids, ovarian reserve, and vitamin D levels in healthy nonobese women. J Clin Endocrinol Metab. 2014; 99(7): 2526–2532.
  26. Lv WS, Zhao WJ, Gong SL, et al. Serum 25-hydroxyvitamin D levels and peripheral neuropathy in patients with type 2 diabetes: a systematic review and meta-analysis. J Endocrinol Invest. 2015; 38(5): 513–518.
  27. Jung CH, Jung SH, Kim KJ, et al. The relationship between vitamin D status and cardiac autonomic neuropathy in patients with type 2 diabetes mellitus. Diab Vasc Dis Res. 2015; 12(5): 342–351.
  28. Berk M, Sanders KM, Pasco JA, et al. Vitamin D deficiency may play a role in depression. Med Hypotheses. 2007; 69(6): 1316–1319.
  29. Bertone-Johnson ER. Vitamin D and the occurrence of depression: causal association or circumstantial evidence? Nutr Rev. 2009; 67(8): 481–492.
  30. Eyles DW, Smith S, Kinobe R, et al. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat. 2005; 29(1): 21–30.
  31. Gozdzik A, Barta JL, Weir A, et al. Serum 25-hydroxyvitamin D concentrations fluctuate seasonally in young adults of diverse ancestry living in Toronto. J Nutr. 2010; 140(12): 2213–2220.