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Oncocytic neoplasms; rare adrenocortical tumours — a report of eleven patients
Affiliations- Department of Internal Medicine, Division of Endocrinology and Metabolism, Kastamonu State Hospital, Kastamonu, Türkiye
- Department of Internal Medicine, Division of Endocrinology and Metabolism, Yunus Emre State Hospital, Eskisehir, Türkiye
- Department of Internal Medicine, Bursa State Hospital, Bursa, Türkiye
- Department of Pathology, Uludag University Faculty of Medicine, Bursa, Türkiye
- Department of Internal Medicine, Division of Endocrinology and Metabolism, Uludag University Faculty of Medicine, Bursa, Türkiye
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Abstract
Introduction: Oncocytomas of adrenal glands are extremely rare and usually present as incidentally detected masses. We aimed to present a series of patients with adrenal oncocytomas and review the literature.
Material and methods: Electronic database of patients with adrenal tumours, who were admitted to the internal medicine and endocrinology and metabolism outpatient clinics of Uludag University Medical Faculty between January 2005 and November 2016, were assessed retrospectively. Those who underwent surgery and pathological diagnosis of oncocytoma (n = 11) were included to the study. The demographic, clinical, pathological, radiological, and laboratory features were evaluated.
Results: Of these 11 patients, 54.5% (n = 6) were female and 45.5% (n = 5) were male. They aged between 31 and 76 years (45.36 ± 13.68). Five (45.5%) of the masses showed endocrinological activity and were more frequent in women. The masses were 25–130 (57.63 ± 34.04) mm in width and 20–100 (47.82 ± 28.95) mm in length. Seven (63.6%) oncocytomas were classified as benign and the remainder as having uncertain malignant potential according to Lin-Weiss-Bisceglia criteria. Mean duration of follow-up were 24.8 (6–60) months and 38.2 (15–82) months, respectively.
Conclusions: Because there are no unique clinical and imaging characteristics differentiating adrenal oncocytomas from other types of adrenal masses, it should be kept in mind in differential diagnosis of adrenal masses, especially large ones and those suspicious for adrenocortical carcinoma.
Abstract
Introduction: Oncocytomas of adrenal glands are extremely rare and usually present as incidentally detected masses. We aimed to present a series of patients with adrenal oncocytomas and review the literature.
Material and methods: Electronic database of patients with adrenal tumours, who were admitted to the internal medicine and endocrinology and metabolism outpatient clinics of Uludag University Medical Faculty between January 2005 and November 2016, were assessed retrospectively. Those who underwent surgery and pathological diagnosis of oncocytoma (n = 11) were included to the study. The demographic, clinical, pathological, radiological, and laboratory features were evaluated.
Results: Of these 11 patients, 54.5% (n = 6) were female and 45.5% (n = 5) were male. They aged between 31 and 76 years (45.36 ± 13.68). Five (45.5%) of the masses showed endocrinological activity and were more frequent in women. The masses were 25–130 (57.63 ± 34.04) mm in width and 20–100 (47.82 ± 28.95) mm in length. Seven (63.6%) oncocytomas were classified as benign and the remainder as having uncertain malignant potential according to Lin-Weiss-Bisceglia criteria. Mean duration of follow-up were 24.8 (6–60) months and 38.2 (15–82) months, respectively.
Conclusions: Because there are no unique clinical and imaging characteristics differentiating adrenal oncocytomas from other types of adrenal masses, it should be kept in mind in differential diagnosis of adrenal masses, especially large ones and those suspicious for adrenocortical carcinoma.
Keywords
adrenal incidentaloma; adrenal oncocytoma; Cushing syndrome; Conn syndrome; undetermined malignant
About this articleTitle
Oncocytic neoplasms; rare adrenocortical tumours — a report of eleven patients
Journal
Issue
Article type
Original paper
Pages
682-687
Published online
2018-09-21
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2640
Article views/downloads
1254
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2018;69(6):682-687.
Keywords
adrenal incidentaloma
adrenal oncocytoma
Cushing syndrome
Conn syndrome
undetermined malignant
Authors
Hande Peynirci
Bengür Taskıran
Nagehan Dik
Özlem Saraydaroğlu
Canan Ersoy
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