open access

Vol 69, No 2 (2018)
Original paper
Published online: 2018-03-29
Submitted: 2017-07-25
Accepted: 2018-01-08
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A follow-up study of patients with MEN syndromes — five case reports

Grzegorz Buła, Witold Truchanowski, Henryk Koziołek, Joanna Polczyk, Paweł Ziora, Jacek Gawrychowski
DOI: 10.5603/EP.2018.0020
·
Pubmed: 29952424
·
Endokrynologia Polska 2018;69(2):163-167.

open access

Vol 69, No 2 (2018)
Original Paper
Published online: 2018-03-29
Submitted: 2017-07-25
Accepted: 2018-01-08

Abstract

THE AIM OF THE STUDY: Evaluation of the results of surgical treatment in patients with hyperparathyroidism related to MEN syndrome MATERIALS AND METHODS: The group of three women and two men aged between 17 and 72 years ( av. 38.6) with MEN- related hyperparathyroidism within 419 patients were operated between 2010-2016. MEN1 syndrome was diagnosed in four patients and MEN2 only once. Pre- and postoperative results of PTH levels and serum calcium values were compared. RESULTS: The mean preoperative serum PTH level was 215,56 pg/ml, whereas calcium concentration was 1.40 mmol/l. Three Patients with MEN1 syndrome had three and two thirds of parathyroid gland taken, and one had a single parathyroid gland excised with biopsy of the rest glands performed. A patient with MEN2 syndrome had one parathyroid gland excised. Postoperatively, we reported decreased secretion of both PTH (a mean serum PTH concentration 6.72 pg/ml), and serum calcium concentration 1.11 mmol/l. One patient (25%) with MEN 1 developed recurrent hyperparathyroidism after five years from the surgery. The patient was reoperated. The rest of the parathyroid gland was removed with an implantation into separated muscle pockets in the anterior forearm muscles. CONCLUSIONS: 1. MEN syndrome is a rare cause of primary hyperparathyroidism. 2. Subtotal parathyroidectomy helps to bring back a normal calcium metabolism. 3. Recurrence of hyperparathyroidism in patients with MEN syndrome requires total parathyroidectomy with an autotransplantation into the anterior forearm muscles.

Abstract

THE AIM OF THE STUDY: Evaluation of the results of surgical treatment in patients with hyperparathyroidism related to MEN syndrome MATERIALS AND METHODS: The group of three women and two men aged between 17 and 72 years ( av. 38.6) with MEN- related hyperparathyroidism within 419 patients were operated between 2010-2016. MEN1 syndrome was diagnosed in four patients and MEN2 only once. Pre- and postoperative results of PTH levels and serum calcium values were compared. RESULTS: The mean preoperative serum PTH level was 215,56 pg/ml, whereas calcium concentration was 1.40 mmol/l. Three Patients with MEN1 syndrome had three and two thirds of parathyroid gland taken, and one had a single parathyroid gland excised with biopsy of the rest glands performed. A patient with MEN2 syndrome had one parathyroid gland excised. Postoperatively, we reported decreased secretion of both PTH (a mean serum PTH concentration 6.72 pg/ml), and serum calcium concentration 1.11 mmol/l. One patient (25%) with MEN 1 developed recurrent hyperparathyroidism after five years from the surgery. The patient was reoperated. The rest of the parathyroid gland was removed with an implantation into separated muscle pockets in the anterior forearm muscles. CONCLUSIONS: 1. MEN syndrome is a rare cause of primary hyperparathyroidism. 2. Subtotal parathyroidectomy helps to bring back a normal calcium metabolism. 3. Recurrence of hyperparathyroidism in patients with MEN syndrome requires total parathyroidectomy with an autotransplantation into the anterior forearm muscles.
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Keywords

multiple endocrine neoplasia, parathyroid neoplasms, hyperparathyroidism, parathyroid glands, parathyroidectomy, thyroid gland, calcium metabolism

About this article
Title

A follow-up study of patients with MEN syndromes — five case reports

Journal

Endokrynologia Polska

Issue

Vol 69, No 2 (2018)

Article type

Original paper

Pages

163-167

Published online

2018-03-29

DOI

10.5603/EP.2018.0020

Pubmed

29952424

Bibliographic record

Endokrynologia Polska 2018;69(2):163-167.

Keywords

multiple endocrine neoplasia
parathyroid neoplasms
hyperparathyroidism
parathyroid glands
parathyroidectomy
thyroid gland
calcium metabolism

Authors

Grzegorz Buła
Witold Truchanowski
Henryk Koziołek
Joanna Polczyk
Paweł Ziora
Jacek Gawrychowski

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