Evaluation of vitamin D concentration in a population of young, healthy women — the effects of vitamin D supplementation
Abstract
Introduction: The goal of the study was an evaluation of serum vitamin D concentrations in healthy young women.
Material and methods: A total of 106 healthy women, aged 20–30 years, were included in the study. Monthly evaluation — for three months — of the effects of calcium (500 mg) and vitamin D (1500 IU) administration in women with baseline values of vitamin D < 20 ng/mL (Group 1) plus the effects of an 800 IU/d dose in women with the baseline value of D > 20 ng/mL (Group 2). Additionally, calcium and PTH concentrations were assessed at the study onset and after a three-month supplementation. Only 67 women adhered to the prescribed therapeutic regime during the three months of observation.
Results: The mean vitamin D concentration in the entire study group was 16.56 ng/mL, being 12.6 ng/mL in Group 1 and 25.22 ng/mL in Group 2. In the course of vitamin D administration, its concentration increased statistically significantly, both in the entire group and in the subgroups, at all time points compared with the study onset. Moreover, its concentration in the whole population and in Group 1 was significantly higher in each of the time points not only in relation to the baseline, but also in comparison with the results of the previous measurements (after 1 and 2 months of supplementation). In Group 2, vitamin D levels also increased systematically throughout the whole study period, and after 3 months its concentration was significantly higher than after 1 and 2 months. Although there were no differences in calcium concentration after those three months, a statistically significant drop of PTH (p < 0.05) was recorded in the entire population and in Group 1.
Conclusions: A moderate deficiency of vitamin D was observed in the studied population of young women. A supplementation with calcium plus vitamin D brought about an increase of vitamin D concentration as early as in the first month of administration. The optimal concentration of > 30 ng/mL was achieved in Group 1 after three months of vitamin D administration in 1500 IU/d dose.
Keywords: vitamin Dsupplementationyoung womenaged 20–30
References
- Bone Health and Osteoporosis: A Report of the Surgeon General.: Office of the Surgeon General (US). SourceRockville (MD) 2004.
- NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, March 7-29, 2000: highlights of the conference. South Med J. 2001; 94(6): 569–573.
- Dawson-Hughes B. Calcium insufficiency and fracture risk. Osteoporosis International. 1996; 6(S3): 37–41.
- Bischoff-Ferrari HA, Rees JR, Grau MV, et al. Effect of calcium supplementation on fracture risk: a double-blind randomized controlled trial. Am J Clin Nutr. 2008; 87(6): 1945–1951.
- Ross AC, Taylor CL, Yaktine AL, et al. Calcium, Institute of Medicine Committee to Review Dietary Reference Intakes for Calcium and Vitamin D. National Academies Press (US) : 2011.
- DeLuca HF. Evolution of our understanding of vitamin D. Nutr Rev. 2008; 66(10 Suppl 2): S73–S87.
- Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357(3): 266–281.
- Konijeti GG, Arora P, Boylan MR, et al. Vitamin D Supplementation Modulates T Cell-Mediated Immunity in Humans: Results from a Randomized Control Trial. J Clin Endocrinol Metab. 2016; 101(2): 533–538.
- Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev. 1998; 78(4): 1193–1231.
- Penckofer S, Kouba J, Wallis DE, et al. Vitamin D and diabetes: let the sunshine in. Diabetes Educ. 2008; 34(6): 939–40, 942, 944 passim.
- Holick MF. Diabetes and the vitamin d connection. Curr Diab Rep. 2008; 8(5): 393–398.
- Guessous I, Bochud M, Bonny O, et al. Calcium, vitamin D and cardiovascular disease. Kidney Blood Press Res. 2011; 34(6): 404–417.
- Pludowski P, Holick MF, Pilz S, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev. 2013; 12(10): 976–989.
- Bertone-Johnson ER. Vitamin D and the occurrence of depression: causal association or circumstantial evidence? Nutr Rev. 2009; 67(8): 481–492.
- Chiang M, Natarajan R, Fan X. Vitamin D in schizophrenia: a clinical review. Evid Based Ment Health. 2016; 19(1): 6–9.
- Clelland JD, Read LL, Drouet V, et al. Vitamin D insufficiency and schizophrenia risk: evaluation of hyperprolinemia as a mediator of association. Schizophr Res. 2014; 156(1): 15–22.
- Grant WB, Wimalawansa SJ, Holick MF, et al. Emphasizing the health benefits of vitamin D for those with neurodevelopmental disorders and intellectual disabilities. Nutrients. 2015; 7(3): 1538–1564.
- Holick MF. Vitamin D: physiology, molecular biology and clinical applications. Totowa, New Jersey: Humana Press. ; 1999: 1–16.
- Rosen CJ. Clinical practice. Vitamin D insufficiency. N Engl J Med. 2011; 364(3): 248–254.
- Schoor Nv, Lips P. Worldwide vitamin D status. Best Practice & Research Clinical Endocrinology & Metabolism. 2011; 25(4): 671–680.
- Guessous I, Dudler V, Glatz N, et al. Swiss Survey on Salt Group. Vitamin D levels and associated factors: a population-based study in Switzerland. Swiss Med Wkly. 2012; 142: 0.
- Płudowski P, Konstantynowicz J, Jaworski M, et al. Standardy Med Pediatria. 2014; 11: 609–617.
- Kmieć P, Żmijewski M, Lizakowska-Kmieć M, et al. Widespread vitamin D deficiency among adults from northern Poland (54°N) after months of low and high natural UVB radiation. Endokrynol Pol. 2015; 66(1): 30–38.
- Kmieć P, Żmijewski M, Waszak P, et al. Vitamin D deficiency during winter months among an adult, predominantly urban, population in Northern Poland. Endokrynol Pol. 2014; 65(2): 105–113.
- Ganmaa D, Holick MF, Rich-Edwards JW, et al. Vitamin D deficiency in reproductive age Mongolian women: a cross sectional study. J Steroid Biochem Mol Biol. 2014; 139: 1–6.
- Wilger-Gahche JJ, Bailey RL, Burt VL, et al. Mean daily intake of calcium, folate and vitamin D from dietary supplements and the proportion getting above certain Dietary Reference Intake (DRI) levels, in the U.S. population ages 14 years and older: Third National Health and Nutrition Examination Survey (NHANES III) and NHANES, 1999-2006. The FASEB Journal 2009; 23. ; 341: 7.
- Bailey RL, Dodd KW, Goldman JA, et al. Estimation of total usual calcium and vitamin D intakes in the United States. J Nutr. 2010; 140(4): 817–822.
- Munns CF, Shaw N, Kiely M, et al. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. J Clin Endocrinol Metab. 2016; 101: 394–415.
- Munns CF, Shaw N, Kiely M, et al. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. Horm Res Paediatr. 2016; 85(2): 83–106.
- Heaney RP. Calcium and obesity: effect size and clinical relevance. Nutr Rev. 2011; 69(6): 333–334.
- Sun Z, Wang PP, Roebothan B, et al. Calcium and vitamin D and risk of colorectal cancer: results from a large population-based case-control study in Newfoundland and Labrador and Ontario. Can J Public Health. 2011; 102(5): 382–389.
- Mitri J, Dawson-Hughes B, Hu FB, et al. Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial. Am J Clin Nutr. 2011; 94(2): 486–494.
- Wang Lu, Manson JE, Buring JE, et al. Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women. Hypertension. 2008; 51(4): 1073–1079.
- Tamer G, Mesci B, Tamer I, et al. Is vitamin D deficiency an independent risk factor for obesity and abdominal obesity in women? Endokrynol Pol. 2012; 63(3): 196–201.
- Garanty-Bogacka B, Syrenicz M, Rać M, et al. Serum 25-hydroxyvitamin D (25-OH-D) in obese adolescents. Endokrynol Pol. 2011; 62(6): 506–511.
- Rosen CJ, Adams JS, Bikle DD, et al. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 2012; 33(3): 456–492.
- Bolland MJ, Grey A, Reid IR. Should we prescribe calcium or vitamin D supplements to treat or prevent osteoporosis? Climacteric. 2015; 18(sup2): 22–31.
- Pludowski P, Grant W, Bhattoa H, et al. Vitamin D Status in Central Europe. Int J Endocrinol. 2014; 2014: 1–12.
- Nelson ML, Blum JM, Hollis BW, et al. Supplements of 20 microg/d cholecalciferol optimized serum 25-hydroxyvitamin D concentrations in 80% of premenopausal women in winter. J Nutr. 2009; 139(3): 540–546.
- Smith SM, Gardner KK, Locke J, et al. Vitamin D supplementation during Antarctic winter. Am J Clin Nutr. 2009; 89(4): 1092–1098.
- Holick MF, Biancuzzo RM, Chen TC, et al. Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab. 2008; 93(3): 677–681.
- Biancuzzo RM, Young A, Bibuld D, et al. Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adults. Am J Clin Nutr. 2010; 91(6): 1621–1626.
- Rajakumar K, Moore CG, Yabes J, et al. Effect of Vitamin D3 Supplementation in Black and in White Children: A Randomized, Placebo-Controlled Trial. J Clin Endocrinol Metab. 2015; 100(8): 3183–3192.
- Gallagher JC, Jindal PS, Smith LM. Vitamin D supplementation in young White and African American women. J Bone Miner Res. 2014; 29(1): 173–181.
- Cosman F, Shen V, Morgan D, et al. Biochemical responses of bone metabolism to 1,25-dihydroxyvitamin D administration in black and white women. Osteoporos Int. 2000; 11(3): 271–277.
- Shieh A, Chun RF, Ma C, et al. Effects of High-Dose Vitamin D2 Versus D3 on Total and Free 25-Hydroxyvitamin D and Markers of Calcium Balance. J Clin Endocrinol Metab. 2016; 101(8): 3070–3078.
- Gallagher JC, Sai A, Templin T, et al. Dose response to vitamin D supplementation in postmenopausal women: a randomized trial. Ann Intern Med. 2012; 156(6): 425–437.
- Gallagher JC, Peacock M, Yalamanchili V, et al. Effects of vitamin D supplementation in older African American women. J Clin Endocrinol Metab. 2013; 98(3): 1137–1146.
- Płudowski P, Karczmarewicz E, Bayer M, et al. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe - recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol Pol. 2013; 64(4): 319–327.
