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Ahead of print
Original papers
Published online: 2017-07-07
Submitted: 2016-10-16
Accepted: 2016-12-27
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Evaluation of vitamin D concentration in a population of young, healthy women – effects of vitamin D supplementation

Ewa Sewerynek, Karol Cieślak, Małgorzata Janik, Ewelina Gowin, Michał Stuss
DOI: 10.5603/EP.a2017.0042

open access

Ahead of print
Original papers
Published online: 2017-07-07
Submitted: 2016-10-16
Accepted: 2016-12-27

Abstract

The goal of the study was an evaluation of serum vitamin D concentrations in healthy young women.

Material and methods: 106 healthy women, aged 20-30 years, were included in the study. Monthly evaluation – for three months – of the effects of calcium (500 mg) and vit. D (1500 IU) administration in women with baseline values of vit. D < 20 ng/ml (Group 1) plus the effects of 800 IU/d dose in women with the baseline value of D > 20 ng/ml (Group2). Additionally, calcium and PTH concentrations were assessed at the study onset and after a 3-month supplementation. Only 67 women adhered to prescribed therapeutic regime during 3 months of observation.

Results: The mean vitamin D concentration in the entire study group was 16.55 ng/ml, being 12.6 ng/ml in Group 1 and 25.23 ng/ml in Group2. In the course of vitamin D administration, its concentration increased statistically significantly, both in the entire group and in the subgroups, at all time points vs. the study onset (p<0,001). Moreover, the concentration increase was statistically significant after two and three months, both in the entire group and in Group1. Similarly, in Group2, vitamin D concentration was systematically rising in the course of the observation period but a statistically significant increase was noted vs. the baseline point. Although there were no differences in calcium concentration after those 3 months, a statistically significant drop of PTH (p<0.05) was recorded in the entire population and in Group 1.

Conclusions: A moderate deficiency of vitamin D was observed in the studied population of young women. A supplementation with calcium plus vitamin D brought about an increase of vitamin D concentration already in the 1st month of administration. The optimal concentration of >30 ng/ml was achieved in Group1 after 3 months of vitamin D administration in 1500 IU/d dose.

The study was supported by Axellus LLC (Poland).

Abstract

The goal of the study was an evaluation of serum vitamin D concentrations in healthy young women.

Material and methods: 106 healthy women, aged 20-30 years, were included in the study. Monthly evaluation – for three months – of the effects of calcium (500 mg) and vit. D (1500 IU) administration in women with baseline values of vit. D < 20 ng/ml (Group 1) plus the effects of 800 IU/d dose in women with the baseline value of D > 20 ng/ml (Group2). Additionally, calcium and PTH concentrations were assessed at the study onset and after a 3-month supplementation. Only 67 women adhered to prescribed therapeutic regime during 3 months of observation.

Results: The mean vitamin D concentration in the entire study group was 16.55 ng/ml, being 12.6 ng/ml in Group 1 and 25.23 ng/ml in Group2. In the course of vitamin D administration, its concentration increased statistically significantly, both in the entire group and in the subgroups, at all time points vs. the study onset (p<0,001). Moreover, the concentration increase was statistically significant after two and three months, both in the entire group and in Group1. Similarly, in Group2, vitamin D concentration was systematically rising in the course of the observation period but a statistically significant increase was noted vs. the baseline point. Although there were no differences in calcium concentration after those 3 months, a statistically significant drop of PTH (p<0.05) was recorded in the entire population and in Group 1.

Conclusions: A moderate deficiency of vitamin D was observed in the studied population of young women. A supplementation with calcium plus vitamin D brought about an increase of vitamin D concentration already in the 1st month of administration. The optimal concentration of >30 ng/ml was achieved in Group1 after 3 months of vitamin D administration in 1500 IU/d dose.

The study was supported by Axellus LLC (Poland).

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Keywords

vitamin D; supplementation; young women; aged 20-30

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Title

Evaluation of vitamin D concentration in a population of young, healthy women – effects of vitamin D supplementation

Journal

Endokrynologia Polska

Issue

Ahead of print

Published online

2017-07-07

DOI

10.5603/EP.a2017.0042

Keywords

vitamin D
supplementation
young women
aged 20-30

Authors

Ewa Sewerynek
Karol Cieślak
Małgorzata Janik
Ewelina Gowin
Michał Stuss

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