open access

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Original papers
Published online: 2017-07-06
Submitted: 2016-10-10
Accepted: 2016-11-22
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Acromegaly treatment in Romania. How close are we to disease control?

Dan Alexandru Niculescu, Ionela Florina Baciu, Cristina Capatina, Simona Andreea Galoiu, Monica Livia Gheorghiu, Serban Radian, Raluca Alexandra Trifanescu, Andra Caragheorgheopol, Mihail Coculescu, Catalina Poiana
DOI: 10.5603/EP.a2017.0041

open access

Ahead of print
Original papers
Published online: 2017-07-06
Submitted: 2016-10-10
Accepted: 2016-11-22

Abstract

Introduction: In Romania no nationwide data for acromegaly treatment and control rate are available. Our objective was to assess the acromegaly control rate in a tertiary referral center which covers an important part of Romanian territory and population of patients with acromegaly.

Material and Methods: We reviewed the records of all 164 patients (49 males and 115 female; median age 55 (47, 63.5) years) with newly or previously diagnosed acromegaly who have been assessed at least once in our tertiary referral center between January 1st, 2012 and March 31st, 2016. This sample represents 13.6% of the total expected 1200 Romanian patients with acromegaly and covers 82.9% of counties of Romania. Control of acromegaly was defined as a random serum growth hormone (GH) < 1 ng/mL and an age-normalized serum insulin-like growth factor-I (IGF-I) value. The GH and IGF-I values used for calculation of the control rate were those at the last evaluation. The same assays for GH and IGF-I measurement were used in all patients.

Results: There were 147 treated and 17 untreated patients. Of the 147 patients assessed after therapy, 137 (93.2%) had pituitary surgery, 116 (78.9%) were on medical treatment at the last evaluation and 67 (45.5%) had radiotherapy. Seventy-one (48.3%) had a random GH<1 ng/mL, 54 (36.7%) had a normalized age-adjusted IGF-I and 42 (28.6%) had both normal random serum GH and IGF-I.

Conclusions: In Romania acromegaly benefits from the whole spectrum of therapeutic interventions. However, the control rate remains disappointing.

Abstract

Introduction: In Romania no nationwide data for acromegaly treatment and control rate are available. Our objective was to assess the acromegaly control rate in a tertiary referral center which covers an important part of Romanian territory and population of patients with acromegaly.

Material and Methods: We reviewed the records of all 164 patients (49 males and 115 female; median age 55 (47, 63.5) years) with newly or previously diagnosed acromegaly who have been assessed at least once in our tertiary referral center between January 1st, 2012 and March 31st, 2016. This sample represents 13.6% of the total expected 1200 Romanian patients with acromegaly and covers 82.9% of counties of Romania. Control of acromegaly was defined as a random serum growth hormone (GH) < 1 ng/mL and an age-normalized serum insulin-like growth factor-I (IGF-I) value. The GH and IGF-I values used for calculation of the control rate were those at the last evaluation. The same assays for GH and IGF-I measurement were used in all patients.

Results: There were 147 treated and 17 untreated patients. Of the 147 patients assessed after therapy, 137 (93.2%) had pituitary surgery, 116 (78.9%) were on medical treatment at the last evaluation and 67 (45.5%) had radiotherapy. Seventy-one (48.3%) had a random GH<1 ng/mL, 54 (36.7%) had a normalized age-adjusted IGF-I and 42 (28.6%) had both normal random serum GH and IGF-I.

Conclusions: In Romania acromegaly benefits from the whole spectrum of therapeutic interventions. However, the control rate remains disappointing.

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Keywords

acromegaly; Romania; treatment; control rate

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Title

Acromegaly treatment in Romania. How close are we to disease control?

Journal

Endokrynologia Polska

Issue

Ahead of print

Published online

2017-07-06

DOI

10.5603/EP.a2017.0041

Keywords

acromegaly
Romania
treatment
control rate

Authors

Dan Alexandru Niculescu
Ionela Florina Baciu
Cristina Capatina
Simona Andreea Galoiu
Monica Livia Gheorghiu
Serban Radian
Raluca Alexandra Trifanescu
Andra Caragheorgheopol
Mihail Coculescu
Catalina Poiana

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