open access

Vol 68, No 4 (2017)
Review article
Published online: 2017-08-10
Submitted: 2016-10-02
Accepted: 2016-11-22
Get Citation

The role of selenium in thyroid gland pathophysiology

Michał Stuss, Marta Michalska-Kasiczak, Ewa Sewerynek
DOI: 10.5603/EP.2017.0051
·
Endokrynologia Polska 2017;68(4):440-465.

open access

Vol 68, No 4 (2017)
Review article
Published online: 2017-08-10
Submitted: 2016-10-02
Accepted: 2016-11-22

Abstract

It is now assumed that proper functioning of the thyroid gland (TG), beside iodine, requires also a number of elements, including selenium, iron, zinc, copper, and calcium. In many cases, only an adequate supply of one of these microelements (e.g. iodine) may reveal symptoms resulting from deficits of other microelements (e.g. iron or selenium).

Selenium is accounted to the trace elements of key importance for homeostasis of the human system, in particular, for the proper functioning of the immune system and the TG. Results of epidemiological studies have demonstrated that selenium deficit may affect as many as one billion people in many countries all over the world. A proper sequence of particular supplementations is also worth emphasising for the significant correlations among the supplemented microelements. For example, it has been demonstrated that an excessive supplementation of selenium may enhance the effects of iodine deficit in endemic regions, while proper supplementation of selenium in studied animals may alleviate the consequences of iodine excess, preventing destructive-inflammatory lesions in the TG.

This paper is a summary of the current knowledge on the role of selenium in the functionality of the TG.

Abstract

It is now assumed that proper functioning of the thyroid gland (TG), beside iodine, requires also a number of elements, including selenium, iron, zinc, copper, and calcium. In many cases, only an adequate supply of one of these microelements (e.g. iodine) may reveal symptoms resulting from deficits of other microelements (e.g. iron or selenium).

Selenium is accounted to the trace elements of key importance for homeostasis of the human system, in particular, for the proper functioning of the immune system and the TG. Results of epidemiological studies have demonstrated that selenium deficit may affect as many as one billion people in many countries all over the world. A proper sequence of particular supplementations is also worth emphasising for the significant correlations among the supplemented microelements. For example, it has been demonstrated that an excessive supplementation of selenium may enhance the effects of iodine deficit in endemic regions, while proper supplementation of selenium in studied animals may alleviate the consequences of iodine excess, preventing destructive-inflammatory lesions in the TG.

This paper is a summary of the current knowledge on the role of selenium in the functionality of the TG.

Get Citation

Keywords

selenium, thyroid gland, supplementation

About this article
Title

The role of selenium in thyroid gland pathophysiology

Journal

Endokrynologia Polska

Issue

Vol 68, No 4 (2017)

Pages

440-465

Published online

2017-08-10

DOI

10.5603/EP.2017.0051

Bibliographic record

Endokrynologia Polska 2017;68(4):440-465.

Keywords

selenium
thyroid gland
supplementation

Authors

Michał Stuss
Marta Michalska-Kasiczak
Ewa Sewerynek

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