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Vol 68, No 4 (2017)
Review paper
Submitted: 2016-10-02
Accepted: 2016-11-22
Published online: 2017-08-10
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The role of selenium in thyroid gland pathophysiology

Michał Stuss12, Marta Michalska-Kasiczak1, Ewa Sewerynek13
DOI: 10.5603/EP.2017.0051
·
Pubmed: 28819948
·
Endokrynol Pol 2017;68(4):440-465.
Affiliations
  1. Department of Endocrine Disorders and Bone Metabolism, Chair of Endocrinology, Medical University of Lodz
  2. The Outpatient Clinic of Endocrinology and Osteoporosis Therapy of the Regional Centre of Menopause and Osteoporosis of the Military Teaching Hospital in Lodz, Poland, Poland
  3. The Outpatient Clinic of Endocrinology and Osteoporosis Therapy of the Regional Centre of Menopause and Osteoporosis of the Military Teaching Hospital in Lodz

open access

Vol 68, No 4 (2017)
Review Article
Submitted: 2016-10-02
Accepted: 2016-11-22
Published online: 2017-08-10

Abstract

It is now assumed that proper functioning of the thyroid gland (TG), beside iodine, requires also a number of elements, including selenium, iron, zinc, copper, and calcium. In many cases, only an adequate supply of one of these microelements (e.g. iodine) may reveal symptoms resulting from deficits of other microelements (e.g. iron or selenium).

Selenium is accounted to the trace elements of key importance for homeostasis of the human system, in particular, for the proper functioning of the immune system and the TG. Results of epidemiological studies have demonstrated that selenium deficit may affect as many as one billion people in many countries all over the world. A proper sequence of particular supplementations is also worth emphasising for the significant correlations among the supplemented microelements. For example, it has been demonstrated that an excessive supplementation of selenium may enhance the effects of iodine deficit in endemic regions, while proper supplementation of selenium in studied animals may alleviate the consequences of iodine excess, preventing destructive-inflammatory lesions in the TG.

This paper is a summary of the current knowledge on the role of selenium in the functionality of the TG.

Abstract

It is now assumed that proper functioning of the thyroid gland (TG), beside iodine, requires also a number of elements, including selenium, iron, zinc, copper, and calcium. In many cases, only an adequate supply of one of these microelements (e.g. iodine) may reveal symptoms resulting from deficits of other microelements (e.g. iron or selenium).

Selenium is accounted to the trace elements of key importance for homeostasis of the human system, in particular, for the proper functioning of the immune system and the TG. Results of epidemiological studies have demonstrated that selenium deficit may affect as many as one billion people in many countries all over the world. A proper sequence of particular supplementations is also worth emphasising for the significant correlations among the supplemented microelements. For example, it has been demonstrated that an excessive supplementation of selenium may enhance the effects of iodine deficit in endemic regions, while proper supplementation of selenium in studied animals may alleviate the consequences of iodine excess, preventing destructive-inflammatory lesions in the TG.

This paper is a summary of the current knowledge on the role of selenium in the functionality of the TG.

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Keywords

selenium, thyroid gland, supplementation

About this article
Title

The role of selenium in thyroid gland pathophysiology

Journal

Endokrynologia Polska

Issue

Vol 68, No 4 (2017)

Article type

Review paper

Pages

440-465

Published online

2017-08-10

Page views

11604

Article views/downloads

11368

DOI

10.5603/EP.2017.0051

Pubmed

28819948

Bibliographic record

Endokrynol Pol 2017;68(4):440-465.

Keywords

selenium
thyroid gland
supplementation

Authors

Michał Stuss
Marta Michalska-Kasiczak
Ewa Sewerynek

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