Primary squamous-cell thyroid carcinoma — a successful treatment with five-year follow-up
Abstract
Squamous cell carcinoma is an extremely rare neoplasm of the thyroid (SCTC) that represents no more than 1% of all primary thyroid malignancies. We report a case of a 42-year-old woman with rapidly growing mass in the right lower neck, primarily diagnosed in fineneedle aspiration cytology as a low-differentiated carcinoma. After the surgery, exclusion of all the other possible primary tumour locations, and immunohistochemistry tests, the diagnosis of primary squamous cell carcinoma of the thyroid gland was established. Because of close surgical margins and metastatic neck node, the patient was referred to adjuvant postoperative irradiation. With five-year follow-up the patient is free of disease and still in very good condition.
Keywords: squamous cell thyroid carcinomasurgeryradiotherapy
References
- Makay O, Kaya T, Icoz G, et al. Primary squamous cell carcinoma of the thyroid: report of three cases. Endocr J. 2008; 55(2): 359–364.
- Ab Hadi I, Bliss RD, Lennard TWJ, et al. Primary squamous cell carcinoma of the thyroid gland: a case report and role of radiotherapy. Surgeon. 2007; 5(4): 249–251.
- Syed MI, Stewart M, Syed S, et al. Squamous cell carcinoma of the thyroid gland: primary or secondary disease? J Laryngol Otol. 2011; 125(1): 3–9.
- Laury AR, Perets R, Piao H, et al. A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol. 2011; 35(6): 816–826.
- Shrestha M, Sridhara SK, Leo LJ, et al. Primary squamous cell carcinoma of the thyroid gland: a case report and review. Head Neck. 2013; 35(10): E299–E303.
- Cho JK, Woo SH, Park J, et al. Primary squamous cell carcinomas in the thyroid gland: an individual participant data meta-analysis. Cancer Med. 2014; 3(5): 1396–1403.
- Boya F, Sebo TJ, Kasperbauer JL, et al. Primary squamous cell carcinoma of the thyroid: report of ten cases. Thyroid. 2006; 16(1): 89–93.
- Bolfi F, Domingues MAC, Sobrinho-Simões M, et al. Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology? Case Report in Pathology. 2014; 2014: 301780.
- Kuczmarska A, Patel MD, Mehta N. Primary squamous cell carcinoma of the thyroid. J Cancer Biol Res. 2014; 2(2): 1051.
- Sapalidis K, Anastasiadis I, Panteli N, et al. Primary squamous cell carcinoma of the thyroid gland. J Surg Case Rep. 2014; 12: 1–3.
- Chen KH, Chou YH, Cheng AL. Primary squamous cell carcinoma of the thyroid with cardiac metastases and right ventricle outflow tract obstruction. J Clin Oncol. 2012; 30(26): 260–263.
- Zimmer PW, Wilson D, Bell N. Primary squamous cell carcinoma of the thyroid gland. Mil Med. 2003; 168(2): 124–125.
- Simpson WJ, Carruthers J. Squamous cell carcinoma of the thyroid gland. Am J Surg. 1988; 156(1): 44–46.
- Cook AM, Vini L, Harmer C. Squamous cell carcinoma of the thyroid: outcome of treatment in 16 patients. Eur J Surg Oncol. 1999; 25(6): 606–609.
- Ghoshal S, Bhattacharyya T, Sood A, et al. Palliative radiation in primary squamous cell carcinoma of thyroid: a rare case report. Indian J Palliat Care. 2013; 19(3): 192–194.
- Zhou XH. Primary squamous cell carcinoma of the thyroid. Eur J Surg Oncol. 2002; 28(1): 42–45.