Multimedialna platforma wiedzy medycznej Internetowa Księgarnia Medyczna Kalendarium Konferencji
Endokrynologia Polska
MENU
Shortcuts Submit an article Author Guidelines Polish Society of Endocrinology Reviewers 2022 Redeem voucher Abstracts, 5–7 May 2022, Gliwice

open access

Vol 68, No 5 (2017)
Original paper
Submitted: 2016-07-01
Accepted: 2016-10-31
Published online: 2017-06-01
View PDF Download PDF file
Get Citation

Thyroid cancer post radioactive iodine treatment for hyperthyroidism — case series and review of the literature

Abdallah A Al Eyadeh, Khaldon Al-Sarihin, Suzan Etewi, Ahmed Al-Omari, Rania Atallah Al-Asa'd, Fares Halim Haddad
DOI: 10.5603/EP.a2017.0037
·
Pubmed: 28585680
·
Endokrynol Pol 2017;68(5):561-566.

open access

Vol 68, No 5 (2017)
Original Paper
Submitted: 2016-07-01
Accepted: 2016-10-31
Published online: 2017-06-01

Abstract

Introduction: To assess the rate of thyroid cancer and mortality rate in a cohort of patients who received RAI131 treatment for hyperthyroidism and to report the index cases’ characteristics and management

Material and methods: A cohort of 264 patients who received RAI131 treatment for different causes of thyrotoxicosis were followed up over a period of 18 years (1996–2014) by physical exam, radiological evaluation and serial thyroid function tests.

Results: During the follow up period, three cases of thyroid cancer were identified. The prevalence of thyroid cancer was 1.136% of cases who received RAI131. The relative risk was 378.79 (95% CI: 76.8 < RR < 1868.23). The P value was < 0.0000004 and the SMR is 1.99/1000.

Conclusions: The prevalence of thyroid cancer was 1.136% in the cohort of patients treated with RAI131. Despite the fact that no direct cause-effect relationship between RAI and thyroid cancer could be established, these cases highlights the importance of life-long surveillance of patients who receive RAI131.

Abstract

Introduction: To assess the rate of thyroid cancer and mortality rate in a cohort of patients who received RAI131 treatment for hyperthyroidism and to report the index cases’ characteristics and management

Material and methods: A cohort of 264 patients who received RAI131 treatment for different causes of thyrotoxicosis were followed up over a period of 18 years (1996–2014) by physical exam, radiological evaluation and serial thyroid function tests.

Results: During the follow up period, three cases of thyroid cancer were identified. The prevalence of thyroid cancer was 1.136% of cases who received RAI131. The relative risk was 378.79 (95% CI: 76.8 < RR < 1868.23). The P value was < 0.0000004 and the SMR is 1.99/1000.

Conclusions: The prevalence of thyroid cancer was 1.136% in the cohort of patients treated with RAI131. Despite the fact that no direct cause-effect relationship between RAI and thyroid cancer could be established, these cases highlights the importance of life-long surveillance of patients who receive RAI131.

Full Text:

View PDF Download PDF file
Get Citation

Keywords

toxic multinodular goitre, thyroid cancer, radioactive iodine

About this article
Title

Thyroid cancer post radioactive iodine treatment for hyperthyroidism — case series and review of the literature

Journal

Endokrynologia Polska

Issue

Vol 68, No 5 (2017)

Article type

Original paper

Pages

561-566

Published online

2017-06-01

Page views

1865

Article views/downloads

1347

DOI

10.5603/EP.a2017.0037

Pubmed

28585680

Bibliographic record

Endokrynol Pol 2017;68(5):561-566.

Keywords

toxic multinodular goitre
thyroid cancer
radioactive iodine

Authors

Abdallah A Al Eyadeh
Khaldon Al-Sarihin
Suzan Etewi
Ahmed Al-Omari
Rania Atallah Al-Asa'd
Fares Halim Haddad

References (29)
  1. Pacini F, Castagna MG, Brilli L, et al. ESMO Guidelines Working Group. Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2012; 23 Suppl 7: vii110–vii119.
    CrossRefPubMed
  2. Curado MP, Edwards B, Shin HR. Cancer Incidence in Five Continents, vol. 9 of IARC Scientific Publications, No. IARC, Lyon, France 2007.
  3. Marjani A, Kabir MJ. Incidence of thyroid cancer in Golestan Province of Iran: Some initial observations. Pak J Med Sci. 2008; 24(6): 887–90.
  4. Brown RL, de Souza JA, Cohen EEw. Thyroid cancer: burden of illness and management of disease. J Cancer. 2011; 2: 193–199.
    CrossRefPubMed
  5. Parkin DM, Whelan SL, Ferlay J, et al. eds. Cancer incidence in five continents, volume VIII. IARC Scientific Publication No. 155. Lyon (France): International Agency for Research on Cancer. ; 2002.
    PubMed
  6. Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA. 2006; 295(18): 2164–2167.
    CrossRefPubMed
  7. Metso S, Auvinen A, Huhtala H, et al. Increased cancer incidence after radioiodine treatment for hyperthyroidism. Cancer. 2007; 109(10): 1972–1979.
    CrossRef
  8. Ron E, Doody MM, Becker DV, et al. Cancer mortality following treatment for adult hyperthyroidism. Cooperative Thyrotoxicosis Therapy Follow-up Study Group. JAMA. 1998; 280(4): 347–355.
    CrossRefPubMed
  9. Franklyn JA, Maisonneuve P, Sheppard M, et al. Cancer incidence and mortality after radioiodine treatment for hyperthyroidism: a population-based cohort study. Lancet. 1999; 353(9170): 2111–2115.
    CrossRefPubMed
  10. Holm LE, Hall P, Lundell G, et al. Cancer risk after iodine-131 therapy for hyperthyroidism. J Natl Cancer Inst. 1991; 83(15): 1072–1077.
    CrossRefPubMed
  11. Ghazi FS, Mohammad RT, Kamal HA, et al. Epidemiology of Thyroid Cancer in Jordan from 1996 to 2008. Middle East Journal of Cancer 2011; 2 (3. ; 4: 117–123.
  12. www.trading economics.com/Jordan/death-rate-crude-per-1-000-people-wb-data.html (June 2015).
  13. Mazzaferri EL. Management of a solitary thyroid nodule. N Engl J Med. 1993; 328(8): 553–559.
    CrossRefPubMed
  14. Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA. 2006; 295(18): 2164–2167.
  15. Belfiore A, Russo D, Vigneri R, et al. Graves' disease, thyroid nodules and thyroid cancer. Clin Endocrinol (Oxf). 2001; 55(6): 711–718.
    CrossRefPubMed
  16. Pellegriti G, Frasca F, Regalbuto C, et al. Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors. J Cancer Epidemiol. 2013; 2013: 965212.
    CrossRefPubMed
  17. Holm LE. Thyroid cancer after exposure to radioactive 131I. Acta Oncol. 2006; 45(8): 1037–1040.
    CrossRefPubMed
  18. Staffurth JS, Holl-Allen RT. Follicular carcinoma of the thyroid following radioactive iodine treatment for Graves' disease. Postgraduate Medical Journal. 1988; 64(757): 878–880.
    CrossRef
  19. DeGroot LJ. Radioiodine and the immune system. Thyroid. 1997; 7(2): 259–264.
    CrossRefPubMed
  20. Fujikawa M, Okamura K, Sato K, et al. Anaplastic transformation of a papillary carcinoma of the thyroid in a patient with Graves' disease with varied activity of thyrotropin receptor antibodies. Thyroid. 1998; 8(1): 53–58.
    CrossRefPubMed
  21. Hoffmann S, Hofbauer LC, Scharrenbach V, et al. Thyrotropin (TSH)-induced production of vascular endothelial growth factor in thyroid cancer cells in vitro: evaluation of TSH signal transduction and of angiogenesis-stimulating growth factors. J Clin Endocrinol Metab. 2004; 89(12): 6139–6145.
    CrossRefPubMed
  22. Smeesters P, Frühling J, Van Bladel L, et al. [Nuclear accidents and iodine prophylaxis. Part 1: Risks due to irradiation of the thyroid gland]. Rev Med Brux. 1998; 19(6): 475–482.
    PubMed
  23. Klugbauer S, Pfeiffer P, Gassenhuber H, et al. RET rearrangements in radiation-induced papillary thyroid carcinomas: high prevalence of topoisomerase I sites at breakpoints and microhomology-mediated end joining in ELE1 and RET chimeric genes. Genomics. 2001; 73(2): 149–160.
    CrossRefPubMed
  24. Ogawa M, Hori H, Hirayama M, et al. Anaplastic transformation from papillary thyroid carcinoma with increased serum CA19-9. Pediatr Blood Cancer. 2005; 45(1): 64–67.
    CrossRefPubMed
  25. Sturgis CD. Radioactive iodine-associated cytomorphologic alterations in thyroid follicular epithelium: is recognition possible in fine-needle aspiration specimens? Diagn Cytopathol. 1999; 21(3): 207–210, doi: 10.1002/(sici)1097-0339(199909)21:3<207::aid-dc13>3.0.co;2-e.
    PubMed
  26. Kim SH, Kim HY, Jung KY, et al. Anaplastic thyroid carcinoma following radioactive iodine therapy for graves' disease. Endocrinol Metab (Seoul). 2013; 28(1): 61–64.
    CrossRefPubMed
  27. Baker H. Anaplastic thyroid cancer twelve years after radioiodine therapy. Cancer. 1969; 23(4): 885–890, doi: 10.1002/1097-0142(196904)23:4<885::aid-cncr2820230425>3.0.co;2-r.
  28. Gossage AA, Neal FE, Ross CM, et al. Cases of carcinoma of thyroid following iodine-131 therapy for hyperthyroidism. Oncology. 1984; 41(1): 8–12.
    CrossRefPubMed
  29. Rivkees SA, Dinauer C. An optimal treatment for pediatric Graves' disease is radioiodine. J Clin Endocrinol Metab. 2007; 92(3): 797–800.
    CrossRefPubMed

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą jest  VM Media Group sp. z o.o., Grupa Via Medica, ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl