open access

Vol 68, No 4 (2017)
Original paper
Published online: 2017-05-31
Submitted: 2016-06-13
Accepted: 2017-04-11
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Adipokine profile in patients with anorexia nervosa

Agnieszka Baranowska-Bik, Bogusława Baranowska, Lidia Martyńska, Anna Litwiniuk, Małgorzata Kalisz, Jan Kochanowski, Wojciech Bik
DOI: 10.5603/EP.a2017.0035
·
Pubmed: 28604943
·
Endokrynologia Polska 2017;68(4):422-429.

open access

Vol 68, No 4 (2017)
Original Paper
Published online: 2017-05-31
Submitted: 2016-06-13
Accepted: 2017-04-11

Abstract

Introduction: Anorexia nervosa (AN) is an eating disorder characterised with extremely low weight. Adipokines are adipose tissue-derived substances that show a wide spectrum of biological activities. We aimed to assess selected adipokine levels in women with AN before and after nutritional intervention. We also sought to examine whether BMI is the only confounding factor influencing adipokine assessment in AN.

Material and methods: Sixty-five women participated in the study: 20 individuals with AN before any treatment, 18 AN patients after nutritional intervention lasting for at least six months, and 27 women as controls. In all participants blood collection and anthropometric measurements were performed. ELISA was used for evaluation of leptin receptor, adiponectin and its isoforms, and resistin. Leptin was assessed with RIA, and visfatin was measured with EIA assay.

Results: Leptin and free leptin index (FLI) were lowest in treatment–naïve AN women. HMW-adiponectin and visfatin were enhanced in AN. Other adipokine levels showed no significant differences. When two subsets of anorexia nervosa were compared, only leptin, leptin receptor, and FLI were markedly different. When data were adjusted to BMI, leptin and FLI remained significantly different in the pre-treated AN subgroup when compared with the control group.

Conclusions: Our results suggest that leptin is the most important adipokine in AN. It is also important that in our AN population leptin and FLI are the only factors that are influenced not only by the fat content.

Abstract

Introduction: Anorexia nervosa (AN) is an eating disorder characterised with extremely low weight. Adipokines are adipose tissue-derived substances that show a wide spectrum of biological activities. We aimed to assess selected adipokine levels in women with AN before and after nutritional intervention. We also sought to examine whether BMI is the only confounding factor influencing adipokine assessment in AN.

Material and methods: Sixty-five women participated in the study: 20 individuals with AN before any treatment, 18 AN patients after nutritional intervention lasting for at least six months, and 27 women as controls. In all participants blood collection and anthropometric measurements were performed. ELISA was used for evaluation of leptin receptor, adiponectin and its isoforms, and resistin. Leptin was assessed with RIA, and visfatin was measured with EIA assay.

Results: Leptin and free leptin index (FLI) were lowest in treatment–naïve AN women. HMW-adiponectin and visfatin were enhanced in AN. Other adipokine levels showed no significant differences. When two subsets of anorexia nervosa were compared, only leptin, leptin receptor, and FLI were markedly different. When data were adjusted to BMI, leptin and FLI remained significantly different in the pre-treated AN subgroup when compared with the control group.

Conclusions: Our results suggest that leptin is the most important adipokine in AN. It is also important that in our AN population leptin and FLI are the only factors that are influenced not only by the fat content.

Get Citation

Keywords

leptin; soluble leptin receptor; free leptin index; adiponectin; resistin; visfatin; anorexia nervosa

About this article
Title

Adipokine profile in patients with anorexia nervosa

Journal

Endokrynologia Polska

Issue

Vol 68, No 4 (2017)

Article type

Original paper

Pages

422-429

Published online

2017-05-31

DOI

10.5603/EP.a2017.0035

Pubmed

28604943

Bibliographic record

Endokrynologia Polska 2017;68(4):422-429.

Keywords

leptin
soluble leptin receptor
free leptin index
adiponectin
resistin
visfatin
anorexia nervosa

Authors

Agnieszka Baranowska-Bik
Bogusława Baranowska
Lidia Martyńska
Anna Litwiniuk
Małgorzata Kalisz
Jan Kochanowski
Wojciech Bik

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