open access

Vol 68, No 4 (2017)
Original papers
Published online: 2017-05-30
Submitted: 2016-05-10
Accepted: 2016-08-23
Get Citation

The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506)

Władysław Grzeszczak, Maciej Molsa, Marek Tłuczykont, Anna Markowicz, Ryszard Swoboda, Marta Biedak, Anna Kałuża, Sebastian Sirek, Krzysztof Strojek
DOI: 10.5603/EP.a2017.0032
·
Endokrynologia Polska 2017;68(4):402-406.

open access

Vol 68, No 4 (2017)
Original papers
Published online: 2017-05-30
Submitted: 2016-05-10
Accepted: 2016-08-23

Abstract

Introduction: Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. Fat mass and obesity-associated protein (FTO) is one of the genes of interest to us. Hypomethylation of a CpG site in the FTO gene was significantly associated with the risk of T2DM. The aim of the study was to find the answer to the question of whether the polymorphism changes of the FTO gene in the pathogenesis of type 2 diabetes are comparable in young, middle aged, and elderly people.

Material and methods: The study involved 282 consecutive patients with type 2 diabetes, who attended a primary healthcare clinic in Southern Poland. The study subjects were divided into three groups according to the age at which type 2 diabetes mellitus was diagnosed (> 40 years old, 40–60 years old, and > 60 years old). The genotyping of rs9939609, rs1421085, and rs9930506 FTO polymorphisms was conducted using TaqManPre-designed SNP Genotyping Assay.

Results: No statistically significant difference was shown between the examined FTO polymorphism (rs9939609, rs1421085, and rs9930506) distribution between the subjects diagnosed with diabetes < 40 years , 40–60 years, and > 60 years old.

Conclusions: There were no statistically significant relationships between the different analysed anthropometric and other parameters and distribution of examined FTO polymorphisms (rs9939609 , rs1421085, and rs9930506). The age of diabetes was not affect by the tested FTO polymorphisms (rs9939609 , rs1421085, and rs9930506).

Abstract

Introduction: Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. Fat mass and obesity-associated protein (FTO) is one of the genes of interest to us. Hypomethylation of a CpG site in the FTO gene was significantly associated with the risk of T2DM. The aim of the study was to find the answer to the question of whether the polymorphism changes of the FTO gene in the pathogenesis of type 2 diabetes are comparable in young, middle aged, and elderly people.

Material and methods: The study involved 282 consecutive patients with type 2 diabetes, who attended a primary healthcare clinic in Southern Poland. The study subjects were divided into three groups according to the age at which type 2 diabetes mellitus was diagnosed (> 40 years old, 40–60 years old, and > 60 years old). The genotyping of rs9939609, rs1421085, and rs9930506 FTO polymorphisms was conducted using TaqManPre-designed SNP Genotyping Assay.

Results: No statistically significant difference was shown between the examined FTO polymorphism (rs9939609, rs1421085, and rs9930506) distribution between the subjects diagnosed with diabetes < 40 years , 40–60 years, and > 60 years old.

Conclusions: There were no statistically significant relationships between the different analysed anthropometric and other parameters and distribution of examined FTO polymorphisms (rs9939609 , rs1421085, and rs9930506). The age of diabetes was not affect by the tested FTO polymorphisms (rs9939609 , rs1421085, and rs9930506).

Get Citation

Keywords

diabetes type 2; FTO gene; age

About this article
Title

The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506)

Journal

Endokrynologia Polska

Issue

Vol 68, No 4 (2017)

Pages

402-406

Published online

2017-05-30

DOI

10.5603/EP.a2017.0032

Bibliographic record

Endokrynologia Polska 2017;68(4):402-406.

Keywords

diabetes type 2
FTO gene
age

Authors

Władysław Grzeszczak
Maciej Molsa
Marek Tłuczykont
Anna Markowicz
Ryszard Swoboda
Marta Biedak
Anna Kałuża
Sebastian Sirek
Krzysztof Strojek

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Via MedicaWydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl