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The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506)
Affiliations- Department of Internal Medicine, Diabetology and Nephrology in Zabrze, Medical University of Silesia in Katowice, Poland
- Department of Internal Medicine, Diabetology and Nephrology in Zabrze, Medical University of Silesia in Katowice
- Department of Internal Diseases, Diabetology and Cardiometabolic Diseases, SMDZ in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, Zabrze, Poland
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Abstract
Introduction: Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. Fat mass and obesity-associated protein (FTO) is one of the genes of interest to us. Hypomethylation of a CpG site in the FTO gene was significantly associated with the risk of T2DM. The aim of the study was to find the answer to the question of whether the polymorphism changes of the FTO gene in the pathogenesis of type 2 diabetes are comparable in young, middle aged, and elderly people.
Material and methods: The study involved 282 consecutive patients with type 2 diabetes, who attended a primary healthcare clinic in Southern Poland. The study subjects were divided into three groups according to the age at which type 2 diabetes mellitus was diagnosed (> 40 years old, 40–60 years old, and > 60 years old). The genotyping of rs9939609, rs1421085, and rs9930506 FTO polymorphisms was conducted using TaqManPre-designed SNP Genotyping Assay.
Results: No statistically significant difference was shown between the examined FTO polymorphism (rs9939609, rs1421085, and rs9930506) distribution between the subjects diagnosed with diabetes < 40 years , 40–60 years, and > 60 years old.
Conclusions: There were no statistically significant relationships between the different analysed anthropometric and other parameters and distribution of examined FTO polymorphisms (rs9939609 , rs1421085, and rs9930506). The age of diabetes was not affect by the tested FTO polymorphisms (rs9939609 , rs1421085, and rs9930506).
Abstract
Introduction: Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. Fat mass and obesity-associated protein (FTO) is one of the genes of interest to us. Hypomethylation of a CpG site in the FTO gene was significantly associated with the risk of T2DM. The aim of the study was to find the answer to the question of whether the polymorphism changes of the FTO gene in the pathogenesis of type 2 diabetes are comparable in young, middle aged, and elderly people.
Material and methods: The study involved 282 consecutive patients with type 2 diabetes, who attended a primary healthcare clinic in Southern Poland. The study subjects were divided into three groups according to the age at which type 2 diabetes mellitus was diagnosed (> 40 years old, 40–60 years old, and > 60 years old). The genotyping of rs9939609, rs1421085, and rs9930506 FTO polymorphisms was conducted using TaqManPre-designed SNP Genotyping Assay.
Results: No statistically significant difference was shown between the examined FTO polymorphism (rs9939609, rs1421085, and rs9930506) distribution between the subjects diagnosed with diabetes < 40 years , 40–60 years, and > 60 years old.
Conclusions: There were no statistically significant relationships between the different analysed anthropometric and other parameters and distribution of examined FTO polymorphisms (rs9939609 , rs1421085, and rs9930506). The age of diabetes was not affect by the tested FTO polymorphisms (rs9939609 , rs1421085, and rs9930506).
Keywords
diabetes type 2; FTO gene; age
About this articleTitle
The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506)
Journal
Issue
Article type
Original paper
Pages
402-406
Published online
2017-05-30
Page views
1644
Article views/downloads
1523
DOI
10.5603/EP.a2017.0032
Pubmed
Bibliographic record
Endokrynol Pol 2017;68(4):402-406.
Keywords
diabetes type 2
FTO gene
age
Authors
Władysław Grzeszczak
Maciej Molsa
Marek Tłuczykont
Anna Markowicz
Ryszard Swoboda
Marta Biedak
Anna Kałuża
Sebastian Sirek
Krzysztof Strojek
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