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Vol 68, No 4 (2017)
Original paper
Published online: 2017-05-30

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The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506)

Władysław Grzeszczak1, Maciej Molsa2, Marek Tłuczykont2, Anna Markowicz2, Ryszard Swoboda2, Marta Biedak2, Anna Kałuża2, Sebastian Sirek2, Krzysztof Strojek3
Pubmed: 28585683
Endokrynol Pol 2017;68(4):402-406.

Abstract

Introduction: Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. Fat mass and obesity-associated protein (FTO) is one of the genes of interest to us. Hypomethylation of a CpG site in the FTO gene was significantly associated with the risk of T2DM. The aim of the study was to find the answer to the question of whether the polymorphism changes of the FTO gene in the pathogenesis of type 2 diabetes are comparable in young, middle aged, and elderly people.

Material and methods: The study involved 282 consecutive patients with type 2 diabetes, who attended a primary healthcare clinic in Southern Poland. The study subjects were divided into three groups according to the age at which type 2 diabetes mellitus was diagnosed (> 40 years old, 40–60 years old, and > 60 years old). The genotyping of rs9939609, rs1421085, and rs9930506 FTO polymorphisms was conducted using TaqManPre-designed SNP Genotyping Assay.

Results: No statistically significant difference was shown between the examined FTO polymorphism (rs9939609, rs1421085, and rs9930506) distribution between the subjects diagnosed with diabetes < 40 years , 40–60 years, and > 60 years old.

Conclusions: There were no statistically significant relationships between the different analysed anthropometric and other parameters and distribution of examined FTO polymorphisms (rs9939609 , rs1421085, and rs9930506). The age of diabetes was not affect by the tested FTO polymorphisms (rs9939609 , rs1421085, and rs9930506).

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