open access

Vol 67, No 6 (2016)
Original papers
Published online: 2016-12-30
Submitted: 2016-04-12
Accepted: 2016-06-30
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The influence of INS VNTR class III allele on auxological parameters, glucose, insulin, lipids, and adipocytokines secretion in prepubertal children born small for gestational age

Renata Stawerska, Małgorzata Szałapska, Maciej Borowiec, Karolina Antosik, Wojciech Młynarski, Andrzej Lewiński
DOI: 10.5603/EP.2016.0068
·
Endokrynologia Polska 2016;67(6):585-591.

open access

Vol 67, No 6 (2016)
Original papers
Published online: 2016-12-30
Submitted: 2016-04-12
Accepted: 2016-06-30

Abstract

Introduction: The insulin gene variable number of tandem repeats (INS VNTR) class III allele has been implicated in lower birth weight, obesity, and insulin resistance. We assessed its influence on birth weight in the Polish population and on the current body mass and metabolic profile in prepubertal children born small for gestational age (SGA).

Material and methods: DNA for genotyping of INS VNTR was available for 123 subjects born SGA and 132 born appropriate for gestational age (AGA). We identified two alleles: class I and class III. Next, in 112 prepubertal (aged: 6.8 ± 1.38 years) SGA children, the auxological measurements, fasting serum C-peptide, triglycerides, cholesterol, ghrelin, leptin, adiponectin, resistin, cortisol, and insulin-like growth factor type I (IGF-I) concentrations, as well as glucose and insulin during oral glucose tolerance test (OGTT), were assessed and insulin resistance indices were calculated. The results were analysed depending on INS VNTR variants.

Results: The occurrence of individual INS VNTR variants were similar in the SGA and AGA groups. In prepubertal SGA children, we did not observe any statistical differences as regards birth weight, body mass, lipids, or adipocytokine concentrations among I/I, I/III, and III/III class groups. The concentration of insulin in 120’ of OGTT was significantly higher in class III homozygous than in class I homozygous individuals.

Conclusions: Variant INS VNTR class III was shown not to be associated in any essential way with birth weight in the Polish population. Among prepubertal SGA children, the presence of INS VNTR class III is related to higher insulin secretion during OGTT. (Endokrynol Pol 2016; 67 (6): 585–591)

Abstract

Introduction: The insulin gene variable number of tandem repeats (INS VNTR) class III allele has been implicated in lower birth weight, obesity, and insulin resistance. We assessed its influence on birth weight in the Polish population and on the current body mass and metabolic profile in prepubertal children born small for gestational age (SGA).

Material and methods: DNA for genotyping of INS VNTR was available for 123 subjects born SGA and 132 born appropriate for gestational age (AGA). We identified two alleles: class I and class III. Next, in 112 prepubertal (aged: 6.8 ± 1.38 years) SGA children, the auxological measurements, fasting serum C-peptide, triglycerides, cholesterol, ghrelin, leptin, adiponectin, resistin, cortisol, and insulin-like growth factor type I (IGF-I) concentrations, as well as glucose and insulin during oral glucose tolerance test (OGTT), were assessed and insulin resistance indices were calculated. The results were analysed depending on INS VNTR variants.

Results: The occurrence of individual INS VNTR variants were similar in the SGA and AGA groups. In prepubertal SGA children, we did not observe any statistical differences as regards birth weight, body mass, lipids, or adipocytokine concentrations among I/I, I/III, and III/III class groups. The concentration of insulin in 120’ of OGTT was significantly higher in class III homozygous than in class I homozygous individuals.

Conclusions: Variant INS VNTR class III was shown not to be associated in any essential way with birth weight in the Polish population. Among prepubertal SGA children, the presence of INS VNTR class III is related to higher insulin secretion during OGTT. (Endokrynol Pol 2016; 67 (6): 585–591)

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Keywords

INS VNTR; small for gestational age; children; obesity; insulin resistance; adipocytokines

About this article
Title

The influence of INS VNTR class III allele on auxological parameters, glucose, insulin, lipids, and adipocytokines secretion in prepubertal children born small for gestational age

Journal

Endokrynologia Polska

Issue

Vol 67, No 6 (2016)

Pages

585-591

Published online

2016-12-30

DOI

10.5603/EP.2016.0068

Bibliographic record

Endokrynologia Polska 2016;67(6):585-591.

Keywords

INS VNTR
small for gestational age
children
obesity
insulin resistance
adipocytokines

Authors

Renata Stawerska
Małgorzata Szałapska
Maciej Borowiec
Karolina Antosik
Wojciech Młynarski
Andrzej Lewiński

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