open access

Vol 67, No 6 (2016)
Original papers
Published online: 2016-12-31
Submitted: 2016-03-16
Accepted: 2016-05-11
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Vaspin and selected indices of bone status in girls with anorexia nervosa

Zofia Ostrowska, Katarzyna Ziora, Joanna Oświęcimska, Elżbieta Świętochowska, Bogdan Marek, Dariusz Kajdaniuk, Joanna Strzelczyk, Karolina Gołąbek, Małgorzata Morawiecka-Pietrzak, Kinga Wołkowska-Pokrywa, Beata Kos-Kudła
DOI: 10.5603/EP.2016.0070
·
Endokrynologia Polska 2016;67(6):599-606.

open access

Vol 67, No 6 (2016)
Original papers
Published online: 2016-12-31
Submitted: 2016-03-16
Accepted: 2016-05-11

Abstract

Introduction: In vitro studies indicate that vaspin may act as a regulator of bone metabolism. The aim of the study was to evaluate the relationship between vaspin and bone metabolism in girls with anorexia nervosa (AN), as well as the potential involvement of OPG and RANKL in this relationship.

Material and methods: Serum vaspin, OC, CTx, OPG, and sRANKL were determined by ELISA in 50 girls with AN and in 30 healthy controls aged 13 to 17 years.

Results: Girls with AN exhibited significant reduction in body weight, BMI, and Cole index as well as a significant increase in serum level of vaspin compared to healthy participants. These changes were associated with a significant decrease in serum OC and CTx levels and a significant increase in OPG and sRANKL, while the OPG/sRANKL ratio was significantly decreased. BMI and Cole index correlated negatively and significantly with CTx levels in the control group (C), girls with AN, and all study participants (C+AN). Girls with AN showed a significant negative correlation between BMI, the Cole index, and OPG levels. The combination group (C+AN) showed a significant positive correlation between BMI, Cole index, and the OPG/sRANKL ratio. In this group of girls vaspin levels correlated positively and significantly with sRANKL and negatively with body weight, BMI, Cole index, and OPG/sRANKL ratio. Girls with AN showed a significant negative correlation between vaspin levels and the OPG/sRANKL ratio.

Conclusions: Undernourishment and associated deficit of adipose tissue may result in inadequate vaspin production and bone metabolism disorders in girls with AN. Vaspin acts as a coordinator of the dynamic balance between bone formation and resorption processes; its action is affected by the cytokines of the RANKL/RANK/OPG system. Changes in the relationships between vaspin, bone markers, OPG, and RANKL might contribute to the development of osteoporosis in girls with AN. (Endokrynol Pol 2016; 67 (6): 599–606)

Abstract

Introduction: In vitro studies indicate that vaspin may act as a regulator of bone metabolism. The aim of the study was to evaluate the relationship between vaspin and bone metabolism in girls with anorexia nervosa (AN), as well as the potential involvement of OPG and RANKL in this relationship.

Material and methods: Serum vaspin, OC, CTx, OPG, and sRANKL were determined by ELISA in 50 girls with AN and in 30 healthy controls aged 13 to 17 years.

Results: Girls with AN exhibited significant reduction in body weight, BMI, and Cole index as well as a significant increase in serum level of vaspin compared to healthy participants. These changes were associated with a significant decrease in serum OC and CTx levels and a significant increase in OPG and sRANKL, while the OPG/sRANKL ratio was significantly decreased. BMI and Cole index correlated negatively and significantly with CTx levels in the control group (C), girls with AN, and all study participants (C+AN). Girls with AN showed a significant negative correlation between BMI, the Cole index, and OPG levels. The combination group (C+AN) showed a significant positive correlation between BMI, Cole index, and the OPG/sRANKL ratio. In this group of girls vaspin levels correlated positively and significantly with sRANKL and negatively with body weight, BMI, Cole index, and OPG/sRANKL ratio. Girls with AN showed a significant negative correlation between vaspin levels and the OPG/sRANKL ratio.

Conclusions: Undernourishment and associated deficit of adipose tissue may result in inadequate vaspin production and bone metabolism disorders in girls with AN. Vaspin acts as a coordinator of the dynamic balance between bone formation and resorption processes; its action is affected by the cytokines of the RANKL/RANK/OPG system. Changes in the relationships between vaspin, bone markers, OPG, and RANKL might contribute to the development of osteoporosis in girls with AN. (Endokrynol Pol 2016; 67 (6): 599–606)

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Keywords

anorexia nervosa; girls; vaspin; bone metabolism; OPG; sRANKL; OPG/sRANKL ratio

About this article
Title

Vaspin and selected indices of bone status in girls with anorexia nervosa

Journal

Endokrynologia Polska

Issue

Vol 67, No 6 (2016)

Pages

599-606

Published online

2016-12-31

DOI

10.5603/EP.2016.0070

Bibliographic record

Endokrynologia Polska 2016;67(6):599-606.

Keywords

anorexia nervosa
girls
vaspin
bone metabolism
OPG
sRANKL
OPG/sRANKL ratio

Authors

Zofia Ostrowska
Katarzyna Ziora
Joanna Oświęcimska
Elżbieta Świętochowska
Bogdan Marek
Dariusz Kajdaniuk
Joanna Strzelczyk
Karolina Gołąbek
Małgorzata Morawiecka-Pietrzak
Kinga Wołkowska-Pokrywa
Beata Kos-Kudła

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