We give you this year’s last issue of “Endokrynologia Polska”. It ends the 10-year period of our current Editorial Board’s activity. Such a moment is usually the time for summaries and making conclusions from our achievements. The most important one shall be your opinion – our Readers’ opinion.

We would like to thank the Authors for cooperation and Reviewers for the effort made to justly evaluate the manuscripts, which are coming in growing numbers. We are extremely happy of it, yet we are forced to reject over 80% of submitted articles.

This last 2015 issue of EP is opened by a original paper which blends into the current research trend of analyzing thromboembolic events in endocrine diseases. In the article, an attempt has been made to describe the way in which thyroid problems may affect the coagulation cascade and it was shown that among patients with suspicion of thromboembolism, TSH concentration is an independent prognostic factor of their presence, parallel to sex, age and D-dimer and CRP levels.

Some research showed that there is an increased risk of thyroid nodules occurrence in patients with increased blood TSH concentration, even if the concentration does not exceed the cutoff value. The results of the published study suggest that in patients with thyroid nodules, risk of cancer increases parallel to plasma TSH concentration, which is even more visible in patients with TSH above 1.64 mU/L. An association between increased TSH concentration and nodule size was also noted.

In another paper, no differences were shown in prognostic value of plasma post-operative thyroglobulin and stimulated post-ablative thyroglobulin concentrations. The latter, however, at concentration of ≤ 1.24 ng/mL allows prognosis of disease remission with better sensitivity and can have a prognostic significance in patients with basal high risk of spread of the disease.

Thyroid metastases are revealed in autopsy with frequency of 2–24%, however, they are clinically identified in only 0.1–3%. The aim of one of the papers was the analysis of the frequency of revealing thyroid and neck lymph node metastases other than primary thyroid tumors in thyroid diagnostics in patients with positive and negative tumor history, as well as USG analysis of the metastases.

In the next paper, early and remote results of microsurgical treatment of corticotroph adenomas in Nelson’s syndrome obtained in one of the Polish neurosurgical centers were presented.

Demonstrating relations between omentin-1 and a series of bone tissue markers in girls with anorexia nervosa indicates an adipokine participation in dynamic regulation of balance between bone formation and bone resorption, which is the topic of another research paper. Omentin-1 has a negative effect on bone remodeling in patients, affecting both bone formation and its resorption.

Next article is devoted to ^99mTc-sestamibi, which is a pharmaceutical agent used in evaluation of cardiac muscle perfusion. Due to its oncophilic properties, it sometimes allows to show thyroid gland pathology. In 12.4% of patients subjected to cardiac scintigraphy, an abnormal concentration of radioactive tracer in the thyroid was identified. In 31.7% of them, multinodular goiter was identified, in 29.2% a single nodule, in 26.8% autoimmune thyroid disease, and in 2.4% papillary thyroid cancer. On the other hand, in 29.2% of abnormal concentration of radioactive tracer, no thyroid disease was identified.

In the last research paper, designed in order to evaluate the protective effect of L-arginine and Vitamin C supplementation on the content of visceral adipose tissue and insulin resistance in rats on a diet rich in fat, interesting conclusions have been made. L-arginine supplementation may protect the rats on high fat diet from cumulating visceral fat through influencing metalloproteinases activity and improving insulin sensitivity.

A review article published in this issue of EP comes from Great Britain. Its authors familiarize the readers with the notion and significance of kisspeptins, especially in the aspect of their role in fertility and reproduction.

The first of the presented case reports comes from a center in Lodz and raises the problem of occurrence of familial partial lipodystrophy in the context of polycystic ovary syndrome diagnosis.

The second paper in this category, coming from India, describes a very rare and well-documented case of pituitary gland amyloidosis. The authors suggest existence of a potentially new association between macular amyloidosis and clinical course of macroprolactinoma.

Holidays are coming, therefore on behalf of the whole Editorial Board and mine I wish you Merry Christmas full of family warmth and happiness, many achievements and success in the forthcoming year.

On behalf of the Editorial Board

Beata Kos-Kudla