open access

Vol 67, No 5 (2016)
Original papers
Published online: 2016-01-25
Submitted: 2015-09-23
Accepted: 2015-11-30
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Time-dependent irisin concentration changes in patients affected by overt hypothyroidism

Ariadna Zybek-Kocik, Nadia Sawicka-Gutaj, Elżbieta Wrotkowska, Jerzy Sowiński, Marek Ruchała
DOI: 10.5603/EP.a2016.0030
·
Endokrynologia Polska 2016;67(5):476-480.

open access

Vol 67, No 5 (2016)
Original papers
Published online: 2016-01-25
Submitted: 2015-09-23
Accepted: 2015-11-30

Abstract

Introduction: Irisin, a cleaved and secreted part of the transmembrane protein FNDC5, is a recently discovered adipo-myokine that is said to have a significant influence on body metabolism. Changes in thyrometabolic state may also alter the serum irisin level. Since already reported data are not fully consistent, the aim of the present research is to evaluate the time-dependent changes in serum irisin level in patients affected by overt hypothyroidism.

Material and methods: The study involved 36 subjects — two groups of 12 patients with long-lasting (AITD) and short-term (TC) overt hypothyroidism, and a control group (CG) of 12 subjects, matched for age and gender. Serum irisin level, thyrometabolic state, creatine kinase (CK — muscle damage marker), glucose, and insulin concentration were assessed and compared between groups.

Results: The irisin level was significantly lower in AITD than in TC and CG (p = 0.02; p < 0.01; respectively) patients, with no statistical difference between TC and CG (p > 0.05). There was no significant difference between free triiodothyronine and free thyroxine levels in AITD and TC patients (p > 0.05). CK concentration was significantly higher in AITD than in CG patients (p < 0.01) with no difference between AITD and TC patients (p > 0.05) as well as TC and CG patients (p > 0.05). Additionally, the CK level negatively correlated with the irisin level (r = –0.58; p < 0.01).

Conclusions: In conclusion, the irisin concentration changes during thyroid function impairment may be time-dependent. Patients with prolonged hypothyroidism have lower irisin levels that those with short-term disorder. (Endokrynol Pol 2016; 67 (5): 476–480)

Abstract

Introduction: Irisin, a cleaved and secreted part of the transmembrane protein FNDC5, is a recently discovered adipo-myokine that is said to have a significant influence on body metabolism. Changes in thyrometabolic state may also alter the serum irisin level. Since already reported data are not fully consistent, the aim of the present research is to evaluate the time-dependent changes in serum irisin level in patients affected by overt hypothyroidism.

Material and methods: The study involved 36 subjects — two groups of 12 patients with long-lasting (AITD) and short-term (TC) overt hypothyroidism, and a control group (CG) of 12 subjects, matched for age and gender. Serum irisin level, thyrometabolic state, creatine kinase (CK — muscle damage marker), glucose, and insulin concentration were assessed and compared between groups.

Results: The irisin level was significantly lower in AITD than in TC and CG (p = 0.02; p < 0.01; respectively) patients, with no statistical difference between TC and CG (p > 0.05). There was no significant difference between free triiodothyronine and free thyroxine levels in AITD and TC patients (p > 0.05). CK concentration was significantly higher in AITD than in CG patients (p < 0.01) with no difference between AITD and TC patients (p > 0.05) as well as TC and CG patients (p > 0.05). Additionally, the CK level negatively correlated with the irisin level (r = –0.58; p < 0.01).

Conclusions: In conclusion, the irisin concentration changes during thyroid function impairment may be time-dependent. Patients with prolonged hypothyroidism have lower irisin levels that those with short-term disorder. (Endokrynol Pol 2016; 67 (5): 476–480)

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Keywords

irisin; hypothyroidism; autoimmune thyroid disease; muscle damage

About this article
Title

Time-dependent irisin concentration changes in patients affected by overt hypothyroidism

Journal

Endokrynologia Polska

Issue

Vol 67, No 5 (2016)

Pages

476-480

Published online

2016-01-25

DOI

10.5603/EP.a2016.0030

Bibliographic record

Endokrynologia Polska 2016;67(5):476-480.

Keywords

irisin
hypothyroidism
autoimmune thyroid disease
muscle damage

Authors

Ariadna Zybek-Kocik
Nadia Sawicka-Gutaj
Elżbieta Wrotkowska
Jerzy Sowiński
Marek Ruchała

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