open access
Primary hyperparathyroidism in pregnancy — a diagnostic and therapeutic challenge
open access
Abstract
Hypercalcaemia during pregnancy is uncommon, and mostly associated with primary hyperparathyroidism (pHPT). If unrecognised, it poses a significant risk for the mother and the foetus. Maternal symptoms include: hyperemesis, muscle weakness, pancreatitis, nephrolithiasis, bone disease, mental status changes, and hypercalcaemic crisis. Untreated disease complicates foetal development and foetal death is a significant risk. Our case illustrates the difficulty in detecting pHPT during pregnancy, serious complications connected with severe hypercalcaemia, and difficulties in preparing the patient for surgical treatment. Our review of the medical literature did not identify any previous case of a pregnant woman with hypercalcaemic crisis (total calcium 17 mg/dL, parathyroid hormone 2302 pg/mL), acute pancreatitis caused by pHPT, and with hyperthyroidism, who had undergone a successful surgical treatment. (Endokrynol Pol 2015; 66 (3): 270–274)
Abstract
Hypercalcaemia during pregnancy is uncommon, and mostly associated with primary hyperparathyroidism (pHPT). If unrecognised, it poses a significant risk for the mother and the foetus. Maternal symptoms include: hyperemesis, muscle weakness, pancreatitis, nephrolithiasis, bone disease, mental status changes, and hypercalcaemic crisis. Untreated disease complicates foetal development and foetal death is a significant risk. Our case illustrates the difficulty in detecting pHPT during pregnancy, serious complications connected with severe hypercalcaemia, and difficulties in preparing the patient for surgical treatment. Our review of the medical literature did not identify any previous case of a pregnant woman with hypercalcaemic crisis (total calcium 17 mg/dL, parathyroid hormone 2302 pg/mL), acute pancreatitis caused by pHPT, and with hyperthyroidism, who had undergone a successful surgical treatment. (Endokrynol Pol 2015; 66 (3): 270–274)
Keywords
primary hyperparathyroidism; hypercalcaemic crisis; pregnancy; acute pancreatitis
About this articleTitle
Primary hyperparathyroidism in pregnancy — a diagnostic and therapeutic challenge
Journal
Issue
Article type
Case report
Pages
270-274
Published online
2015-07-01
Page views
1974
Article views/downloads
2734
DOI
10.5603/EP.2015.0034
Pubmed
Bibliographic record
Endokrynol Pol 2015;66(3):270-274.
Keywords
primary hyperparathyroidism
hypercalcaemic crisis
pregnancy
acute pancreatitis
Authors
Joanna Rutkowska
Elżbieta Bandurska-Stankiewicz
Wojciech Matuszewski
Marek Gowkielewicz
Radosław Goraj
Dariusz Onichimowski
