open access

Vol 66, No 5 (2015)
Original papers
Published online: 2015-10-12
Submitted: 2014-11-03
Accepted: 2015-01-23
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Leptin concentration in children with juvenile idiopathic arthritis

Izabela Maciejewska-Paszek, Elżbieta Grochowska-Niedworok, Andrzej Siwiec, Lechosław Dul, Anna Gruenpeter, Henryk Szczerba, Tomasz Irzyniec
DOI: 10.5603/EP.2015.0013
·
Endokrynologia Polska 2015;66(5):417-421.

open access

Vol 66, No 5 (2015)
Original papers
Published online: 2015-10-12
Submitted: 2014-11-03
Accepted: 2015-01-23

Abstract

Introduction: Leptin regulates the organism’s immune response. Juvenile idiopathic arthritis (JIA) is a chronic joint disease in children, leading to chronic changes in motor organs.

Material and methods: In children with JIA (n = 42) and healthy subjects (n = 28), leptin concentration (LEP), body mass index (BMI), haematocrit (HTC), haemoglobin (HB), morphotic elements (WBC,LYMPH), erythrocyte sedimentation rate (ESR), and ANA Hep-2 antibodies were analysed. JIA group was divided into: children with a longer (51–148 months) (IA) n = 22 and a shorter disease period (2–18 months) (IB) n = 20.

Results: Only 58.3% of the IA and 50% of the IB group had ANA Hep-2 confirmed. The ill children had higher and more diversified LYMPH and ESR levels compared to the healthy children. The highest LEP for the IA group was 37.5 ng/cm3, (Me 5.85), for IB — 40.10 ng/cm3, (Me 2.46) as compared to the IC — 3.74 ng/cm3 (Me 2.85), respectively. The average BMI value for the IA group was 16.61 kg/m2, for IC it was 18.91 kg/m2, and the median for IB was 15.89 kg/m2. Children with BMI values < 23 kg/m2 from the IA and IB group had a reduction in LEP as compared to control group (p = 0.04). The relationship between the illness and LEP diversification per BMI unit was found in both groups. Children with a shorter illness period had higher LEP differentiation per BMI unit compared to the healthy children.

Conclusions:

  1. Children with juvenile idiopathic arthritis with BMI < 23 kg/m2 had lower leptin concentrations than healthy subjects.
  2. Ill children with a shorter-term disease had a higher diversification of leptin concentration per BMI unit as compared to healthy controls. (Endokrynol Pol 2015; 66 (5): 417–421)

Abstract

Introduction: Leptin regulates the organism’s immune response. Juvenile idiopathic arthritis (JIA) is a chronic joint disease in children, leading to chronic changes in motor organs.

Material and methods: In children with JIA (n = 42) and healthy subjects (n = 28), leptin concentration (LEP), body mass index (BMI), haematocrit (HTC), haemoglobin (HB), morphotic elements (WBC,LYMPH), erythrocyte sedimentation rate (ESR), and ANA Hep-2 antibodies were analysed. JIA group was divided into: children with a longer (51–148 months) (IA) n = 22 and a shorter disease period (2–18 months) (IB) n = 20.

Results: Only 58.3% of the IA and 50% of the IB group had ANA Hep-2 confirmed. The ill children had higher and more diversified LYMPH and ESR levels compared to the healthy children. The highest LEP for the IA group was 37.5 ng/cm3, (Me 5.85), for IB — 40.10 ng/cm3, (Me 2.46) as compared to the IC — 3.74 ng/cm3 (Me 2.85), respectively. The average BMI value for the IA group was 16.61 kg/m2, for IC it was 18.91 kg/m2, and the median for IB was 15.89 kg/m2. Children with BMI values < 23 kg/m2 from the IA and IB group had a reduction in LEP as compared to control group (p = 0.04). The relationship between the illness and LEP diversification per BMI unit was found in both groups. Children with a shorter illness period had higher LEP differentiation per BMI unit compared to the healthy children.

Conclusions:

  1. Children with juvenile idiopathic arthritis with BMI < 23 kg/m2 had lower leptin concentrations than healthy subjects.
  2. Ill children with a shorter-term disease had a higher diversification of leptin concentration per BMI unit as compared to healthy controls. (Endokrynol Pol 2015; 66 (5): 417–421)
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Keywords

juvenile idiopathic arthritis; leptin; BMI

About this article
Title

Leptin concentration in children with juvenile idiopathic arthritis

Journal

Endokrynologia Polska

Issue

Vol 66, No 5 (2015)

Pages

417-421

Published online

2015-10-12

DOI

10.5603/EP.2015.0013

Bibliographic record

Endokrynologia Polska 2015;66(5):417-421.

Keywords

juvenile idiopathic arthritis
leptin
BMI

Authors

Izabela Maciejewska-Paszek
Elżbieta Grochowska-Niedworok
Andrzej Siwiec
Lechosław Dul
Anna Gruenpeter
Henryk Szczerba
Tomasz Irzyniec

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