open access

Vol 66, No 3 (2015)
Original papers
Published online: 2015-07-01
Submitted: 2014-10-23
Accepted: 2014-11-09
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Assessment of platelet function in endogenous hypercortisolism

Renata Świątkowska-Stodulska, Andrzej Mital, Piotr Wiśniewski, Anna Babińska, Anna Skibowska-Bielińska, Krzysztof Sworczak
DOI: 10.5603/EP.2015.0014
·
Endokrynologia Polska 2015;66(3):207-213.

open access

Vol 66, No 3 (2015)
Original papers
Published online: 2015-07-01
Submitted: 2014-10-23
Accepted: 2014-11-09

Abstract

Introduction: It is commonly known that glucocorticoids exert a significant effect on haemostasis. Studies that have analysed the plasmatic coagulation system and fibrinolysis parameters in hypercortisolaemic patients are abundant. Platelet function, which plays a vital role in primary haemostasis, is much less clear in this context.
We aimed at assessing platelet function in endogenous hypercortisolaemic patients.
Material and methods: Twenty-five hypercortisolaemic patients were included in the study. Twelve of them were diagnosed with overt Cushing’s syndrome (OCS) and 13 had subclinical Cushing’s syndrome (SCS). Thirty healthy volunteers comprised the control group. In all subjects platelet function parameters were examined: ADP- and collagen-induced platelet aggregation (ADP-IPA and Col-IPA, respectively), IMPACT R (expressed as percentage of surface covered (SC) by platelets and average size (AS) of the adhering particles in μm2), as well as closure time (CT) after platelet activation with agonists: ADP and Col or Col and epinephrine (EPI). The statistical significance level was set at 0.05.
Results: There was no significant difference in mean values of ADP-IPA, Col-IPA, Col/Epi CT, Col/ADP CT, SC, and AS between hypercortisolaemic subjects and controls. No statistically significant differences in means of examined parameters were found between overt and subclinical Cushing’s syndrome patients. Furthermore, no statistically significant relationships were found between these parameters and hormonal indicators of hypercortisolism: 24-hour urinary cortisol excretion, morning and evening serum cortisol level, and overnight-test
cortisol concentration.
Conclusions: In hypercortisolaemic patients no primary haemostasis disorders are present, as reflected by platelet adhesion and ADP- and collagen-induced aggregation measurements. (Endokrynol Pol 2015; 66 (3): 207–213)

Abstract

Introduction: It is commonly known that glucocorticoids exert a significant effect on haemostasis. Studies that have analysed the plasmatic coagulation system and fibrinolysis parameters in hypercortisolaemic patients are abundant. Platelet function, which plays a vital role in primary haemostasis, is much less clear in this context.
We aimed at assessing platelet function in endogenous hypercortisolaemic patients.
Material and methods: Twenty-five hypercortisolaemic patients were included in the study. Twelve of them were diagnosed with overt Cushing’s syndrome (OCS) and 13 had subclinical Cushing’s syndrome (SCS). Thirty healthy volunteers comprised the control group. In all subjects platelet function parameters were examined: ADP- and collagen-induced platelet aggregation (ADP-IPA and Col-IPA, respectively), IMPACT R (expressed as percentage of surface covered (SC) by platelets and average size (AS) of the adhering particles in μm2), as well as closure time (CT) after platelet activation with agonists: ADP and Col or Col and epinephrine (EPI). The statistical significance level was set at 0.05.
Results: There was no significant difference in mean values of ADP-IPA, Col-IPA, Col/Epi CT, Col/ADP CT, SC, and AS between hypercortisolaemic subjects and controls. No statistically significant differences in means of examined parameters were found between overt and subclinical Cushing’s syndrome patients. Furthermore, no statistically significant relationships were found between these parameters and hormonal indicators of hypercortisolism: 24-hour urinary cortisol excretion, morning and evening serum cortisol level, and overnight-test
cortisol concentration.
Conclusions: In hypercortisolaemic patients no primary haemostasis disorders are present, as reflected by platelet adhesion and ADP- and collagen-induced aggregation measurements. (Endokrynol Pol 2015; 66 (3): 207–213)

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Keywords

primary haemostasis; platelet function; Cushing’s syndrome; subclinical Cushing’s syndrome

About this article
Title

Assessment of platelet function in endogenous hypercortisolism

Journal

Endokrynologia Polska

Issue

Vol 66, No 3 (2015)

Pages

207-213

Published online

2015-07-01

DOI

10.5603/EP.2015.0014

Bibliographic record

Endokrynologia Polska 2015;66(3):207-213.

Keywords

primary haemostasis
platelet function
Cushing’s syndrome
subclinical Cushing’s syndrome

Authors

Renata Świątkowska-Stodulska
Andrzej Mital
Piotr Wiśniewski
Anna Babińska
Anna Skibowska-Bielińska
Krzysztof Sworczak

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