open access

Vol 65, No 5 (2014)
Original papers
Published online: 2014-10-09
Submitted: 2014-10-09
Accepted: 2014-10-09
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Serum resistin concentrations in children with type 1 diabetes mellitus — negative relation to body fat mass

Katarzyna Anna Majewska, Dominik Majewski, Bogda Skowrońska, Piotr Fichna
DOI: 10.5603/EP.2014.0047
·
Endokrynologia Polska 2014;65(5):342-347.

open access

Vol 65, No 5 (2014)
Original papers
Published online: 2014-10-09
Submitted: 2014-10-09
Accepted: 2014-10-09

Abstract

Introduction: Insulin is one of the major factors regulating adipose tissue function. On the other hand, adipocytes secrete adipocytokines that may influence insulin synthesis and action, and are involved in blood glucose regulation. In type 1 diabetes mellitus (t1DM), beta cells function is replaced with exogenous insulin therapy. This raises a question concerning the impact of t1DM on adipose tissue secretory function. The aim of this study was to evaluate one of the adipocytokines, resistin, serum concentrations in relation to body fat mass in children with t1DM.

Material and methods: The study comprised 75 children with t1DM and a control group of 20 healthy coevals. All children had estimated serum resistin concentrations, glycated haemoglobin levels, growth and body weight measurements, and bioelectrical impedance analysis in order to establish body composition.

Results: Resistin serum concentrations were significantly lower in children with t1DM vs. controls (median values: 343 vs. 590 pg/mL; mean values ± SD: 577 ± 561 vs. 861 ± 628 pg/mL; p < 0.001), and they negatively correlated with body fat mass (p = 0.022) and age (p = 0.022) in the t1DM group, but not in the control group. Disease duration, glycated haemoglobin levels and insulin dosage revealed no direct statistical relation to resistin levels.

Conclusions: Diminished serum resistin concentrations and a negative correlation between resistin levels and body fat mass in children with type 1 diabetes seem to result from broken physiological adipo-insular regulations, independent of disease duration, its metabolic control and insulin supply. (Endokrynol Pol 2014; 65 (5): 342–347)

Abstract

Introduction: Insulin is one of the major factors regulating adipose tissue function. On the other hand, adipocytes secrete adipocytokines that may influence insulin synthesis and action, and are involved in blood glucose regulation. In type 1 diabetes mellitus (t1DM), beta cells function is replaced with exogenous insulin therapy. This raises a question concerning the impact of t1DM on adipose tissue secretory function. The aim of this study was to evaluate one of the adipocytokines, resistin, serum concentrations in relation to body fat mass in children with t1DM.

Material and methods: The study comprised 75 children with t1DM and a control group of 20 healthy coevals. All children had estimated serum resistin concentrations, glycated haemoglobin levels, growth and body weight measurements, and bioelectrical impedance analysis in order to establish body composition.

Results: Resistin serum concentrations were significantly lower in children with t1DM vs. controls (median values: 343 vs. 590 pg/mL; mean values ± SD: 577 ± 561 vs. 861 ± 628 pg/mL; p < 0.001), and they negatively correlated with body fat mass (p = 0.022) and age (p = 0.022) in the t1DM group, but not in the control group. Disease duration, glycated haemoglobin levels and insulin dosage revealed no direct statistical relation to resistin levels.

Conclusions: Diminished serum resistin concentrations and a negative correlation between resistin levels and body fat mass in children with type 1 diabetes seem to result from broken physiological adipo-insular regulations, independent of disease duration, its metabolic control and insulin supply. (Endokrynol Pol 2014; 65 (5): 342–347)

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Keywords

resistin; type 1 diabetes; adipose tissue; insulin; children

About this article
Title

Serum resistin concentrations in children with type 1 diabetes mellitus — negative relation to body fat mass

Journal

Endokrynologia Polska

Issue

Vol 65, No 5 (2014)

Pages

342-347

Published online

2014-10-09

DOI

10.5603/EP.2014.0047

Bibliographic record

Endokrynologia Polska 2014;65(5):342-347.

Keywords

resistin
type 1 diabetes
adipose tissue
insulin
children

Authors

Katarzyna Anna Majewska
Dominik Majewski
Bogda Skowrońska
Piotr Fichna

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